Improving Adherence With Amlodipine/Atorvastatin Therapy: IMPACT Study

J Clin Hypertens (Greenwich). 2011;13:598–604.©2011 Wiley Periodicals, Inc. Hypertension is prevalent in the United States and remains uncontrolled. The primary objective of the study was to determine the effect of once‐daily dosing of a combination therapy for blood pressure (BP) and dyslipidemia u...

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Published in:	The journal of clinical hypertension (Greenwich, Conn.) Vol. 13; no. 8; pp. 598 - 604
Main Authors:	Oliver, Saran, Jones, Jennifer, Leonard, David, Crabbe, Andrew, Delkhah, Yana
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-08-2011
Subjects:	Amlodipine - pharmacology Amlodipine - therapeutic use Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Atorvastatin Black or African American Blood Pressure - drug effects Blood Pressure - physiology Cholesterol - blood Comorbidity Dose-Response Relationship, Drug Drug Therapy, Combination Dyslipidemias - drug therapy Dyslipidemias - epidemiology Dyslipidemias - ethnology Female Heptanoic Acids - pharmacology Heptanoic Acids - therapeutic use Humans Hypertension - drug therapy Hypertension - epidemiology Hypertension - ethnology Lipoproteins, LDL - blood Male Middle Aged Original Paper Original Papers Patient Compliance Pyrroles - pharmacology Pyrroles - therapeutic use Treatment Outcome USA
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Summary:	J Clin Hypertens (Greenwich). 2011;13:598–604.©2011 Wiley Periodicals, Inc. Hypertension is prevalent in the United States and remains uncontrolled. The primary objective of the study was to determine the effect of once‐daily dosing of a combination therapy for blood pressure (BP) and dyslipidemia using home BP monitoring on reaching clinical BP and the effect of daily dosing of combination therapy on reaching lipid goals. The study was conducted in middle‐aged, indigent, African Americans who had high‐risk, resistant hypertension and dyslipidemia. Patients were randomly assigned to either the home and clinic BP group or usual care group and were followed for 6 months. The average BPs for each group were compared and used to titrate the study drug appropriately. Both groups achieved significant declines in BP, total cholesterol, and low‐density lipoprotein (LDL) (P<.0001). These findings demonstrate that BP control could be achieved at a rate of 43.5% compared with the 2004 national control rate of 35%. The LDL control rate was also improved. Cardiovascular risk reduction has been proven to be achieved through managing lipids and BP. This trial demonstrates that these goals can be achieved similar to other groups in indigent African Americans with high‐risk hypertension and dyslipidemia.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1524-6175 1751-7176
DOI:	10.1111/j.1751-7176.2011.00478.x