Search Results - "Oliver, Paula M"

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice by Deshmukh, Hitesh S, Liu, Yuhong, Menkiti, Ogechukwu R, Mei, Junjie, Dai, Ning, O'Leary, Claire E, Oliver, Paula M, Kolls, Jay K, Weiser, Jeffrey N, Worthen, G Scott

“…Here, Hitesh S. Deshmukh et al. report that in neonates, establishment of the intestinal microbiota is associated with neutrophil development…”
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Itch regulation of innate and adaptive immune responses in mice and humans by Field, Natania S., Moser, Emily K., Oliver, Paula M.

“…The E3 ubiquitin ligase Itch has long been appreciated to be a critical suppressor of inflammation, first identified as a regulator of Th2 differentiation and…”
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Regulation of autoimmune disease by the E3 ubiquitin ligase Itch by Moser, Emily K., Oliver, Paula M.

“…•Itch plays an essential role to prevent severe autoimmune disease.•Ubiquitylation by Itch regulates protein stability and function for a variety of…”
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Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord by Gorla, Madhavi, Santiago, Celine, Chaudhari, Karina, Layman, Awo Akosua Kesewa, Oliver, Paula M., Bashaw, Greg J.

“…Commissural axons initially respond to attractive signals at the midline, but once they cross, they become sensitive to repulsive cues. This switch prevents…”
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Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice by Mei, Junjie, Liu, Yuhong, Dai, Ning, Hoffmann, Christian, Hudock, Kristin M, Zhang, Peggy, Guttentag, Susan H, Kolls, Jay K, Oliver, Paula M, Bushman, Frederic D, Worthen, G Scott

“…Neutrophils are essential for maintaining innate immune surveillance under normal conditions, but also represent a major contributor to tissue damage during…”
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Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation by Riling, Christopher, Kamadurai, Hari, Kumar, Suresh, O'Leary, Claire E., Wu, Kuen-Phon, Manion, Erica E., Ying, Mingjie, Schulman, Brenda A., Oliver, Paula M.

“…Nedd4-family E3 ubiquitin ligases regulate an array of biologic processes. Autoinhibition maintains these catalytic ligases in an inactive state through…”
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Increased peripheral IL-4 leads to an expanded virtual memory CD8+ population by Kurzweil, Vanessa, LaRoche, Ami, Oliver, Paula M

“…Memory-phenotype CD8(+) T cells can arise even in the absence of overt Ag stimulation. Virtual memory (VM) CD8(+) T cells are CD8(+) T cells that develop a…”
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c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity by Dar, Asif A., Kim, Dale D., Gordon, Scott M., Klinzing, Kathleen, Rosen, Siera, Guha, Ipsita, Porter, Nadia, Ortega, Yohaniz, Forsyth, Katherine S., Roof, Jennifer, Fazelinia, Hossein, Spruce, Lynn A., Eisenlohr, Laurence C., Behrens, Edward M., Oliver, Paula M.

“…During infection, virus-specific CD8 + T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and…”
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The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA by Dar, Asif A, Sawada, Keisuke, Dybas, Joseph M, Moser, Emily K, Lewis, Emma L, Park, Eddie, Fazelinia, Hossein, Spruce, Lynn A, Ding, Hua, Seeholzer, Steven H, Oliver, Paula M

“…The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell…”
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Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease by Layman, Awo Akosua Kesewa, Deng, Guoping, O’Leary, Claire E., Tadros, Samuel, Thomas, Rajan M., Dybas, Joseph M., Moser, Emily K., Wells, Andrew D., Doliba, Nicolai M., Oliver, Paula M.

“…Foxp3 + T regulatory (T reg ) cells suppress immune cell activation and establish normal immune homeostasis. How T reg cells maintain their identity is not…”
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The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation by Kumar, Binod, Field, Natania S., Kim, Dale D., Dar, Asif A., Chen, Yanqun, Suresh, Aishwarya, Pastore, Christopher F., Hung, Li-Yin, Porter, Nadia, Sawada, Keisuke, Shah, Palak, Elbulok, Omar, Moser, Emily K., Herbert, De’Broski R., Oliver, Paula M.

“…Antigen encounter directs CD4 + T cells to differentiate into T helper or regulatory cells. This process focuses the immune response on the invading pathogen…”
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Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells by O’Leary, Claire E., Riling, Christopher R., Spruce, Lynn A., Ding, Hua, Kumar, Suresh, Deng, Guoping, Liu, Yuhong, Seeholzer, Steven H., Oliver, Paula M.

“…Nedd4 family E3 ubiquitin ligases have been shown to restrict T-cell function and impact T-cell differentiation. We show here that Ndfip1 and Ndfip2,…”
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Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production by Layman, Awo Akosua Kesewa, Sprout, Stephanie L., Phillips, Dylan, Oliver, Paula M.

“…While Th17 cells can protect against colonization by pathogenic organisms, they also have the potential to become pathogenic and promote autoimmune and…”
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E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells by Sun, Jianbo, Keim, Celia D, Wang, Jiguang, Kazadi, David, Oliver, Paula M, Rabadan, Raul, Basu, Uttiya

“…Programmed mutagenesis of the immunoglobulin locus of B lymphocytes during class switch recombination (CSR) and somatic hypermutation requires RNA polymerase…”
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Gastrointestinal microbiota do not significantly contribute to T cell activation or GI inflammation in Ndfip1-cKO mice by Kurzweil, Vanessa, Tarangelo, Amy, Oliver, Paula M

“…The bacteria inhabiting the mammalian gastrointestinal (GI) tract play a vital role in normal digestion and immune function. In a healthy host, the immune…”
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CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis by Liu, Yuhong, O'Leary, Claire E., Wang, Liang-Chuan S., Bhatti, Tricia R., Dai, Ning, Kapoor, Veena, Liu, Peihui, Mei, Junjie, Guo, Lei, Oliver, Paula M., Albelda, Steven M., Worthen, G. Scott

“…Neutrophils are important innate immune cells involved in microbial clearance at the sites of infection. However, their role in cancer development is unclear…”
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Loss of the proapoptotic protein, Bim, breaks B cell anergy by Oliver, Paula M, Vass, Tibor, Kappler, John, Marrack, Philippa

“…Although B cells that respond with high avidity to self-antigen are eliminated early in their development, many autoreactive B cells escape elimination and are…”
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Hypertension, Cardiac Hypertrophy, and Sudden Death in Mice Lacking Natriuretic Peptide Receptor A by Oliver, P M, Fox, J E, Kim, R, Rockman, H A, Kim, H S, Reddick, R L, Pandey, K N, Milgram, S L, Smithies, O, Maeda, N

“…Natriuretic peptides, produced in the heart, bind to the natriuretic peptide receptor A (NPRA) and cause vasodilation and natriuresis important in the…”
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B cell expression of E3 ubiquitin ligase Cul4b promotes chronic gammaherpesvirus infection in vivo by Wang, Yiping, Manzi, Mikayla, Feswick, April, Renshaw, Lindsay, Oliver, Paula M, Tibbetts, Scott A, Moser, Emily K

“…The human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are etiologic agents of numerous B cell lymphomas. A hallmark of…”
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CRL4b Inhibition Ameliorates Experimental Autoimmune Encephalomyelitis Progression by Dar, Asif A, Ortega, Yohaniz, Aktas, Sera, Wu, Kenneth, Guha, Ipsita, Porter, Nadia, Rosen, Siera, DeVita, Robert J, Pan, Zhen-Qiang, Oliver, Paula M

“…Multiple sclerosis, and its murine model experimental autoimmune encephalomyelitis (EAE), is a neurodegenerative autoimmune disease of the CNS characterized by…”
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