Search Results - "Oliver, Patsy G"

The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype by Schultz, Matthew J, Holdbrooks, Andrew T, Chakraborty, Asmi, Grizzle, William E, Landen, Charles N, Buchsbaum, Donald J, Conner, Michael G, Arend, Rebecca C, Yoon, Karina J, Klug, Christopher A, Bullard, Daniel C, Kesterson, Robert A, Oliver, Patsy G, O'Connor, Amber K, Yoder, Bradley K, Bellis, Susan L

“…The glycosyltransferase ST6Gal-I, which adds α2-6-linked sialic acids to substrate glycoproteins, has been implicated in carcinogenesis; however, the nature of…”
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Recurrent read-through fusion transcripts in breast cancer by Varley, Katherine E., Gertz, Jason, Roberts, Brian S., Davis, Nicholas S., Bowling, Kevin M., Kirby, Marie K., Nesmith, Amy S., Oliver, Patsy G., Grizzle, William E., Forero, Andres, Buchsbaum, Donald J., LoBuglio, Albert F., Myers, Richard M.

“…Read-through fusion transcripts that result from the splicing of two adjacent genes in the same coding orientation are a recently discovered type of chimeric…”
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RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4 by Kirby, Marie K., Ramaker, Ryne C., Gertz, Jason, Davis, Nicholas S., Johnston, Bobbi E., Oliver, Patsy G., Sexton, Katherine C., Greeno, Edward W., Christein, John D., Heslin, Martin J., Posey, James A., Grizzle, William E., Vickers, Selwyn M., Buchsbaum, Donald J., Cooper, Sara J., Myers, Richard M.

“…Pancreatic adenocarcinoma patients have low survival rates due to late-stage diagnosis and high rates of cancer recurrence even after surgical resection. It is…”
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Genomic regulation of invasion by STAT3 in triple negative breast cancer by McDaniel, Joy M, Varley, Katherine E, Gertz, Jason, Savic, Daniel S, Roberts, Brian S, Bailey, Sarah K, Shevde, Lalita A, Ramaker, Ryne C, Lasseigne, Brittany N, Kirby, Marie K, Newberry, Kimberly M, Partridge, E Christopher, Jones, Angela L, Boone, Braden, Levy, Shawn E, Oliver, Patsy G, Sexton, Katherine C, Grizzle, William E, Forero, Andres, Buchsbaum, Donald J, Cooper, Sara J, Myers, Richard M

“…Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial…”
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PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression by Agarwal, Sumit, Chakravarthi, Balabhadrapatruni V.S.K., Kim, Hyung-Gyoon, Gupta, Nirzari, Hale, Kevin, Balasubramanya, Sai Akshaya Hodigere, Oliver, Patsy G., Thomas, Dafydd G., Eltoum, Isam-Eldin A., Buchsbaum, Donald J., Manne, Upender, Varambally, Sooryanarayana

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor prognosis. There is an urgent need to identify new therapeutic targets…”
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Combined modality therapy with TRAIL or agonistic death receptor antibodies by Amm, Hope M., Oliver, Patsy G., Lee, Choo Hyung, Li, Yufeng, Buchsbaum, Donald J.

“…Molecularly targeted therapies, such as antibodies and small molecule inhibitors have emerged as an important breakthrough in the treatment of many human…”
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212Pb-Labeled Antibody 225.28 Targeted to Chondroitin Sulfate Proteoglycan 4 for Triple-Negative Breast Cancer Therapy in Mouse Models by Kasten, Benjamin, Oliver, Patsy, Kim, Harrison, Fan, Jinda, Ferrone, Soldano, Zinn, Kurt, Buchsbaum, Donald

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis. There is a clinical need for effective, targeted therapy…”
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A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms by Vayalil, Praveen K, Oh, Joo-Yeun, Zhou, Fen, Diers, Anne R, Smith, M Ryan, Golzarian, Hafez, Oliver, Patsy G, Smith, Robin A J, Murphy, Michael P, Velu, Sadanandan E, Landar, Aimee

“…Despite advances in screening and treatment over the past several years, breast cancer remains a leading cause of cancer-related death among women in the…”
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Antitumor Efficacy of TRA-8 Anti-DR5 Monoclonal Antibody Alone or in Combination with Chemotherapy and/or Radiation Therapy in a Human Breast Cancer Model by Buchsbaum, Donald J, Zhou, Tong, Grizzle, William E, Oliver, Patsy G, Hammond, Charlotte J, Zhang, Sijian, Carpenter, Mark, LoBuglio, Albert F

“…Purpose: A monoclonal antibody (TRA-8) has been developed that binds to death receptor 5 (DR5), one of two death receptors bound by tumor necrosis…”
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Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels by Smith, M Ryan, Vayalil, Praveen K, Zhou, Fen, Benavides, Gloria A, Beggs, Reena R, Golzarian, Hafez, Nijampatnam, Bhavitavya, Oliver, Patsy G, Smith, Robin A J, Murphy, Michael P, Velu, Sadanandan E, Landar, Aimee

“…Many cancer cells follow an aberrant metabolic program to maintain energy for rapid cell proliferation. Metabolic reprogramming often involves the upregulation…”
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Treatment of Human Colon Cancer Xenografts with TRA-8 Anti-death Receptor 5 Antibody Alone or in Combination with CPT-11 by OLIVER, Patsy G, LOBUGLIO, Albert F, ZINN, Kurt R, KIM, Hyunki, LI NAN, TONG ZHOU, WENQUAN WANG, BUCHSBAUM, Donald J

“…Purpose: This study was designed to evaluate the in vitro cytotoxicity and in vivo efficacy of TRA-8, a mouse monoclonal antibody that binds to the DR5 death…”
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Enhancement of Glioma Radiotherapy and Chemotherapy Response With Targeted Antibody Therapy Against Death Receptor 5 by Fiveash, John B., M.D, Gillespie, G. Yancey, Ph.D, Oliver, Patsy G., Ph.D, Zhou, Tong, M.D, Belenky, Michael L., M.S, Buchsbaum, Donald J., Ph.D

“…Purpose TRA-8 is an agonistic mouse monoclonal antibody that binds to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor 5, which…”
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Combination Treatment with TRA-8 Anti–Death Receptor 5 Antibody and CPT-11 Induces Tumor Regression in an Orthotopic Model of Pancreatic Cancer by DEROSIER, Leo Christopher, BUCHSBAUM, Donald J, VICKERS, Selwyn M, OLIVER, Patsy G, HUANG, Zhi-Qiang, SELLERS, Jeffrey C, GRIZZLE, William E, WENQUAN WANG, TONG ZHOU, ZINN, Kurt R, LONG, Joshua W

“…Purpose: Evaluate the response of human pancreatic cancer cell lines and orthotopic tumors to TRA-8, an agonistic antibody to death receptor 5, in combination…”
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ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage by Chakraborty, Asmi, Dorsett, Kaitlyn A., Trummell, Hoa Q., Yang, Eddy S., Oliver, Patsy G., Bonner, James A., Buchsbaum, Donald J., Bellis, Susan L.

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Gemcitabine, as a single agent or in combination therapy, remains…”
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TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth by Derosier, Leo Christopher, Vickers, Selwyn M, Zinn, Kurt R, Huang, Zhi, Wang, Wenquan, Grizzle, William E, Sellers, Jeffrey, Stockard, Jr, Cecil R, Zhou, Tong, Oliver, Patsy G, Arnoletti, Pablo, Lobuglio, Albert F, Buchsbaum, Donald J

“…Purpose: To evaluate agonistic TRA-8 monoclonal antibody to human death receptor 5 (DR5) and gemcitabine in vitro and in an orthotopic pancreatic cancer model…”
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STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer by Conway, Megan E, McDaniel, Joy M, Graham, James M, Guillen, Katrin P, Oliver, Patsy G, Parker, Stephanie L, Yue, Peibin, Turkson, James, Buchsbaum, Donald J, Welm, Bryan E, Myers, Richard M, Varley, Katherine E

“…Breast cancers are divided into subtypes with different prognoses and treatment responses based on global differences in gene expression. Luminal breast cancer…”
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Novel Biomimetic Microphysiological Systems for Tissue Regeneration and Disease Modeling by Budhwani, Karim I, Oliver, Patsy G, Buchsbaum, Donald J, Thomas, Vinoy

“…Biomaterials engineered to closely mimic morphology, architecture, and nanofeatures of naturally occurring in vivo extracellular matrices (ECM) have gained…”
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FTY720 enhances the anti-tumor activity of carboplatin and tamoxifen in a patient-derived xenograft model of ovarian cancer by Kreitzburg, Kelly M., Fehling, Samuel C., Landen, Charles N., Gamblin, Tracy L., Vance, Rebecca B., Arend, Rebecca C., Katre, Ashwini A., Oliver, Patsy G., van Waardenburg, Robert C.A.M., Alvarez, Ronald D., Yoon, Karina J.

“…Ovarian cancer is the fifth leading cause of cancer-related deaths among women in the United States. Although most patients respond to frontline therapy,…”
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SRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells by Li, Yonghe, Oliver, Patsy G, Lu, Wenyan, Pathak, Vibha, Sridharan, Sivaram, Augelli-Szafran, Corinne E, Buchsbaum, Donald J, Suto, Mark J

“…Abstract Activation of Wnt/β-catenin signaling is associated with pancreatic and colorectal cancer, among others. To-date, there are no FDA-approved small…”
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Retraction notice to “SRI36160 is a specific inhibitor of Wnt/ -catenin signaling in human pancreatic and colorectal cancer cells” [Canc. Lett. 389C (2017) 41–48] by Li, Yonghe, Oliver, Patsy G., Lu, Wenyan, Pathak, Vibha, Sridharan, Sivaram, Augelli-Szafran, Corinne E., Buchsbaum, Donald J., Suto, Mark J.

“…In particular, SRI36160 greatly inhibits the activity of firefly luciferase in the ATP-dependent luciferase ATPlite assay (Perkin Elmer) for cell proliferation…”
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