Search Results - "Oliver, M. T."

Cancer glycan epitopes: biosynthesis, structure and function by Pearce, Oliver M T

“…Abstract Aberrant glycan epitopes are a classic hallmark of malignant transformation, yet their full clinical potential in cancer diagnostics and therapeutics…”
Get full text

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics by Naba, Alexandra, Pearce, Oliver M. T, Del Rosario, Amanda, Ma, Duanduan, Ding, Huiming, Rajeeve, Vinothini, Cutillas, Pedro R, Balkwill, Frances R, Hynes, Richard O

“…The extracellular matrix (ECM) is a complex meshwork of insoluble fibrillar proteins and signaling factors interacting together to provide architectural and…”
Get full text

Basement membrane stiffness determines metastases formation by Reuten, Raphael, Zendehroud, Sina, Nicolau, Monica, Fleischhauer, Lutz, Laitala, Anu, Kiderlen, Stefanie, Nikodemus, Denise, Wullkopf, Lena, Nielsen, Sebastian Rune, McNeilly, Sarah, Prein, Carina, Rafaeva, Maria, Schoof, Erwin M., Furtwängler, Benjamin, Porse, Bo T., Kim, Hyobin, Won, Kyoung Jae, Sudhop, Stefanie, Zornhagen, Kamilla Westarp, Suhr, Frank, Maniati, Eleni, Pearce, Oliver M. T., Koch, Manuel, Oddershede, Lene Broeng, Van Agtmael, Tom, Madsen, Chris D., Mayorca-Guiliani, Alejandro E., Bloch, Wilhelm, Netz, Roland R., Clausen-Schaumann, Hauke, Erler, Janine T.

“…The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form…”
Get full text

Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation by Wight, Thomas N, Kang, Inkyung, Evanko, Stephen P, Harten, Ingrid A, Chang, Mary Y, Pearce, Oliver M T, Allen, Carys E, Frevert, Charles W

“…The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor…”
Get full text

A red meat-derived glycan promotes inflammation and cancer progression by Samraj, Annie N., Pearce, Oliver M. T., Läubli, Heinz, Crittenden, Alyssa N., Bergfeld, Anne K., Banda, Kalyan, Gregg, Christopher J., Bingman, Andrea E., Secrest, Patrick, Diaz, Sandra L., Varki, Nissi M., Varki, Ajit

“…A well known, epidemiologically reproducible risk factor for human carcinomas is the long-term consumption of “red meat” of mammalian origin. Although multiple…”
Get full text

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer by Läubli, Heinz, Pearce, Oliver M. T., Schwarz, Flavio, Siddiqui, Shoib S., Deng, Lingquan, Stanczak, Michal A., Deng, Liwen, Verhagen, Andrea, Secrest, Patrick, Lusk, Chrissy, Schwartz, Ann G., Varki, Nissi M., Bui, Jack D., Varki, Ajit

“…Certain pathogenic bacteria are known to modulate the innate immune response by decorating themselves with sialic acids, which can engage the myelomonocytic…”
Get full text

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade by Stanczak, Michal A, Rodrigues Mantuano, Natalia, Kirchhammer, Nicole, Sanin, David E, Jacob, Francis, Coelho, Ricardo, Everest-Dass, Arun V, Wang, Jinyu, Trefny, Marcel P, Monaco, Gianni, Bärenwaldt, Anne, Gray, Melissa A, Petrone, Adam, Kashyap, Abhishek S, Glatz, Katharina, Kasenda, Benjamin, Normington, Karl, Broderick, James, Peng, Li, Pearce, Oliver M T, Pearce, Erika L, Bertozzi, Carolyn R, Zippelius, Alfred, Läubli, Heinz

“…Immune checkpoint blockade (ICB) has substantially improved the prognosis of patients with cancer, but the majority experiences limited benefit, supporting the…”
Get more information

Interleukin-6 Stimulates Defective Angiogenesis by Gopinathan, Ganga, Milagre, Carla, Pearce, Oliver M T, Reynolds, Louise E, Hodivala-Dilke, Kairbaan, Leinster, David A, Zhong, Haihong, Hollingsworth, Robert E, Thompson, Richard, Whiteford, James R, Balkwill, Frances

“…The cytokine IL6 has a number of tumor-promoting activities in human and experimental cancers, but its potential as an angiogenic agent has not been fully…”
Get full text

Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies by Pearce, Oliver M. T., Läubli, Heinz, Verhagen, Andrea, Secrest, Patrick, Zhang, Jiquan, Varki, Nissi M., Crocker, Paul R., Bui, Jack D., Varki, Ajit

“…Compelling evidence for naturally occurring immunosurveillance against malignancies informs and justifies some current approaches toward cancer immunotherapy…”
Get full text

Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK by Nolan, Joanne, Pearce, Oliver M T, Screen, Hazel R C, Knight, Martin M, Verbruggen, Stefaan W

“…Organ-on-chip systems are capable of replicating complex tissue structures and physiological phenomena. The fine control of biochemical and biomechanical cues…”
Get full text

Creating 3D physical models to probe student understanding of macromolecular structure by Cooper, A. Kat, Oliver‐Hoyo, M. T.

“…The high degree of complexity of macromolecular structure is extremely difficult for students to process. Students struggle to translate the simplified…”
Get full text

Microsurgical manipulation reveals pre-copulatory function of key genital sclerites by Cocks, Oliver T M, Eady, Paul E

“…The copulatory organs of male insects are generally complex, species-specific arrangements of hardened sclerotized plates bound together by flexible, less…”
Get full text

Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer by Hirani, Priyanka, Gauthier, Valentine, Allen, Carys E., Wight, Thomas N., Pearce, Oliver M. T.

“…A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue…”
Get full text

Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma by Böhm, Steffen, Montfort, Anne, Pearce, Oliver M T, Topping, Joanne, Chakravarty, Probir, Everitt, Gemma L A, Clear, Andrew, McDermott, Jackie R, Ennis, Darren, Dowe, Thomas, Fitzpatrick, Amanda, Brockbank, Elly C, Lawrence, Alexandra C, Jeyarajah, Arjun, Faruqi, Asma Z, McNeish, Iain A, Singh, Naveena, Lockley, Michelle, Balkwill, Frances R

“…The purpose of this study was to assess the effect of neoadjuvant chemotherapy (NACT) on immune activation in stage IIIC/IV tubo-ovarian high-grade serous…”
Get full text

Siglec receptors impact mammalian lifespan by modulating oxidative stress by Schwarz, Flavio, Pearce, Oliver M T, Wang, Xiaoxia, Samraj, Annie N, Läubli, Heinz, Garcia, Javier O, Lin, Hongqiao, Fu, Xiaoming, Garcia-Bingman, Andrea, Secrest, Patrick, Romanoski, Casey E, Heyser, Charles, Glass, Christopher K, Hazen, Stanley L, Varki, Nissi, Varki, Ajit, Gagneux, Pascal

“…Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and…”
Get full text

Sialic acids in cancer biology and immunity by Pearce, Oliver M T, Läubli, Heinz

“…During malignant transformation, glycosylation is heavily altered compared with healthy tissue due to differential expression of glycosyltransferases,…”
Get full text

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer by Zaghdoudi, Sonia, Decaup, Emilie, Belhabib, Ismahane, Samain, Rémi, Cassant‐Sourdy, Stéphanie, Rochotte, Julia, Brunel, Alexia, Schlaepfer, David, Cros, Jérome, Neuzillet, Cindy, Strehaiano, Manon, Alard, Amandine, Tomasini, Richard, Rajeeve, Vinothini, Perraud, Aurélie, Mathonnet, Muriel, Pearce, Oliver MT, Martineau, Yvan, Pyronnet, Stéphane, Bousquet, Corinne, Jean, Christine

“…Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role…”
Get full text

Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens by Pearce, Oliver M. T., Samraj, Annie N., Läubli, Heinz, Varki, Nissi M., Varki, Ajit

Get full text

Tumor's Digest: Macrophage Metabolism Creates a Barrier to T Cells by Tyler, Elly J, Pearce, Oliver M T

“…Changes in the composition and physical properties of the tumor extracellular matrix are linked to poor cytotoxic T-cell infiltration and therapy response, yet…”
Get full text

Enhanced T cell function in a mouse model of human glycosylation by Buchlis, George, Odorizzi, Pamela, Soto, Paula C, Pearce, Oliver M T, Hui, Daniel J, Jordan, Martha S, Varki, Ajit, Wherry, E John, High, Katherine A

“…Clinical evidence for a more active immune response in humans compared with our closest hominid relative, the chimpanzee, includes the progression of HIV…”
Get full text