Search Results - "Oliver, Antony W."

Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres by Khayat, Freddy, Alshmery, Majedh, Pal, Mohinder, Oliver, Antony W, Bianchi, Alessandro

“…Abstract Telomeres protect chromosome ends from unscheduled DNA repair, including from the MRN (MRE11, RAD50, NBS1) complex, which processes double-stranded…”
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Structure of the human RAD17–RFC clamp loader and 9–1–1 checkpoint clamp bound to a dsDNA–ssDNA junction by Day, Matthew, Oliver, Antony W, Pearl, Laurence H

“…Abstract The RAD9–RAD1–HUS1 (9–1–1) clamp forms one half of the DNA damage checkpoint system that signals the presence of substantial regions of…”
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Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans by Boos, Dominik, Sanchez-Pulido, Luis, Rappas, Mathieu, Pearl, Laurence H., Oliver, Antony W., Ponting, Chris P., Diffley, John F.X.

“…Cyclin-dependent kinases (CDKs) play crucial roles in promoting DNA replication and preventing rereplication in eukaryotic cells [ 1–4]. In budding yeast, CDKs…”
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Cryo-EM structure of the Smc5/6 holo-complex by Hallett, Stephen T, Campbell Harry, Isabella, Schellenberger, Pascale, Zhou, Lihong, Cronin, Nora B, Baxter, Jonathan, Etheridge, Thomas J, Murray, Johanne M, Oliver, Antony W

“…Abstract The Smc5/6 complex plays an essential role in the resolution of recombination intermediates formed during mitosis or meiosis, or as a result of the…”
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The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity by Becker, Jordan R., Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W., Bilham, Kirstin, Holt, Abbey B., Blackford, Andrew N., Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven, Chapman, J. Ross

“…53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers…”
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The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks by Ali, Ammar A E, Timinszky, Gyula, Arribas-Bosacoma, Raquel, Kozlowski, Marek, Hassa, Paul O, Hassler, Markus, Ladurner, Andreas G, Pearl, Laurence H, Oliver, Antony W

“…PARP1 is activated by sensing DNA damage, forming ADP-ribose chains that recruit DNA repair and chromatin remodeling factors. PARP1 recognizes DNA damage…”
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The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function by Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L, Hanzlikova, Hana, Oliver, Antony W, Caldecott, Keith W

“…Poly (ADP-ribose) is synthesized at DNA single-strand breaks and can promote the recruitment of the scaffold protein, XRCC1. However, the mechanism and…”
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Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex by Hallett, Stephen T, Schellenberger, Pascale, Zhou, Lihong, Beuron, Fabienne, Morris, Ed, Murray, Johanne M, Oliver, Antony W

“…Abstract The multi-component Smc5/6 complex plays a critical role in the resolution of recombination intermediates formed during mitosis and meiosis, and in…”
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ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX by Baldock, Robert A., Day, Matthew, Wilkinson, Oliver J., Cloney, Ross, Jeggo, Penelope A., Oliver, Antony W., Watts, Felicity Z., Pearl, Laurence H.

“…53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin…”
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Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1 by Polo, Luis M., Xu, Yingqi, Hornyak, Peter, Garces, Fernando, Zeng, Zhihong, Hailstone, Richard, Matthews, Steve J., Caldecott, Keith W., Oliver, Antony W., Pearl, Laurence H.

“…XRCC1 accelerates repair of DNA single-strand breaks by acting as a scaffold protein for the recruitment of Polβ, LigIIIα, and end-processing factors, such as…”
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A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6 by Vondrova, Lucie, Kolesar, Peter, Adamus, Marek, Nociar, Matej, Oliver, Antony W., Palecek, Jan J.

“…The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting (HAWK or KITE) subunits. Mutual…”
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Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein by Day, Matthew, Parry-Morris, Sarah, Houghton-Gisby, Jack, Oliver, Antony W., Pearl, Laurence H.

“…CHK1 is a protein kinase that functions downstream of activated ATR to phosphorylate multiple targets as part of intra-S and G2/M DNA damage checkpoints. Its…”
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Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus by Rivera-Calzada, Angel, Arribas-Bosacoma, Raquel, Ruiz-Ramos, Alba, Escudero-Bravo, Paloma, Boskovic, Jasminka, Fernandez-Leiro, Rafael, Oliver, Antony W., Pearl, Laurence H., Llorca, Oscar

“…Detection of cytosolic DNA is a central element of the innate immunity system against viral infection. The Ku heterodimer, a component of the NHEJ pathway of…”
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Inhibition of MRN activity by a telomere protein motif by Khayat, Freddy, Cannavo, Elda, Alshmery, Majedh, Foster, William R., Chahwan, Charly, Maddalena, Martino, Smith, Christopher, Oliver, Antony W., Watson, Adam T., Carr, Antony M., Cejka, Petr, Bianchi, Alessandro

“…The MRN complex (MRX in Saccharomyces cerevisiae , made of Mre11, Rad50 and Nbs1/Xrs2) initiates double-stranded DNA break repair and activates the Tel1/ATM…”
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TopBP1 utilises a bipartite GINS binding mode to support genome replication by Day, Matthew, Tetik, Bilal, Parlak, Milena, Almeida-Hernández, Yasser, Räschle, Markus, Kaschani, Farnusch, Siegert, Heike, Marko, Anika, Sanchez-Garcia, Elsa, Kaiser, Markus, Barker, Isabel A., Pearl, Laurence H., Oliver, Antony W., Boos, Dominik

“…Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance…”
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The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins by Grundy, Gabrielle J., Rulten, Stuart L., Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W., Pearl, Laurence H., Caldecott, Keith W.

“…The Ku-binding motif (KBM) is a short peptide module first identified in APLF that we now show is also present in Werner syndrome protein (WRN) and in…”
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PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit by Hégarat, Nadia, Vesely, Clare, Vinod, P K, Ocasio, Cory, Peter, Nisha, Gannon, Julian, Oliver, Antony W, Novák, Béla, Hochegger, Helfrid

“…Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its…”
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Structural basis for recruitment of BRCA2 by PALB2 by Oliver, Antony W, Swift, Sally, Lord, Christopher J, Ashworth, Alan, Pearl, Laurence H

“…The breast cancer 2, early onset protein (BRCA2) is central to the repair of DNA damage by homologous recombination. BRCA2 recruits the recombinase RAD51 to…”
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BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands by Day, Matthew, Rappas, Mathieu, Ptasinska, Katie, Boos, Dominik, Oliver, Antony W, Pearl, Laurence H

“…TOPBP1 and its fission yeast homologueRad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of…”
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint by Bigot, Nicolas, Day, Matthew, Baldock, Robert A, Watts, Felicity Z, Oliver, Antony W, Pearl, Laurence H

“…Coordination of the cellular response to DNA damage is organised by multi-domain 'scaffold' proteins, including 53BP1 and TOPBP1, which recognise…”
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