Search Results - "Oliveira Bittencourt, Leonardo"
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Maternal methylmercury exposure changes the proteomic profile of the offspring's salivary glands: Prospects on translational toxicology
Published in PloS one (08-11-2021)“…Methylmercury (MeHg) remains a public health issue since developing organisms are particularly vulnerable to this environmental contaminant. This study…”
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Chronic intoxication by methylmercury leads to oxidative damage and cell death in salivary glands of rats
Published in Metallomics (01-12-2017)“…Methylmercury (MeHg) is one of the most toxic species of mercury, causing several systemic damages; however, its effect on the salivary glands has rarely been…”
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Fluoride exposure during pregnancy and lactation triggers oxidative stress and molecular changes in hippocampus of offspring rats
Published in Ecotoxicology and environmental safety (15-01-2021)“…Long-term exposure to high concentrations of fluoride (F) can damage mineralized and soft tissues such as bones, liver, kidney, intestine, and nervous system…”
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Human cultured IMR-32 neuronal-like and U87 glial-like cells have different patterns of toxicity under fluoride exposure
Published in PloS one (17-06-2021)“…Fluoride (F) is a naturally exists in nature but several studies have indicated it as an environmental toxicant to all leaving beings. Human F exposure has…”
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Is there any association between fluoride exposure and thyroid function modulation? A systematic review
Published in PloS one (09-04-2024)“…Numerous pre-clinical and observational studies have explored the potential effects of fluoride (F) at varying concentrations on diverse systems and organs…”
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Minocycline reduces alveolar bone loss and bone damage in Wistar rats with experimental periodontitis
Published in PloS one (04-10-2024)“…This study aimed to investigate the impact of minocycline on the alveolar bone in experimental periodontitis in rats. Thirty Wistar rats were randomly assigned…”
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A systematic review and meta-analysis of the association between fluoride exposure and neurological disorders
Published in Scientific reports (22-11-2021)“…Different studies have suggested that fluoride is related to neurological disorders in children and adolescents, but clinical evidences of which neurological…”
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Physical training minimizes immunological dysfunction, oxidative stress and tissue destruction on experimental periodontitis in rats
Published in PloS one (06-06-2024)“…The objective of this study is to investigate the effects of a moderate intensity physical training protocol, on alveolar bone morphology of rats submitted to…”
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Cellular and Molecular Pathophysiology of Traumatic Brain Injury: What Have We Learned So Far?
Published in Biology (Basel, Switzerland) (01-08-2023)“…Traumatic brain injury (TBI) is one of the leading causes of long-lasting morbidity and mortality worldwide, being a devastating condition related to the…”
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Physical training attenuates systemic cytokine response and tissue damage triggered by apical periodontitis
Published in Scientific reports (05-04-2024)“…Apical periodontitis (AP) is a condition characterized by inflammatory and infectious components in the tooth canal. AP affects periradicular tissues and has…”
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Prolonged exposure to high fluoride levels during adolescence to adulthood elicits molecular, morphological, and functional impairments in the hippocampus
Published in Scientific reports (08-07-2023)“…Fluoride is added to water due to its anticariogenic activity. However, due to its natural presence in soils and reservoirs at high levels, it could be a…”
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Proteomic approach underlying the hippocampal neurodegeneration caused by low doses of methylmercury after long-term exposure in adult rats
Published in Metallomics (20-02-2019)“…Methylmercury (MeHg) is an important toxicant that causes cognitive dysfunctions in humans. This study aimed to investigate the proteomic and biochemical…”
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Global research trends on maternal exposure to methylmercury and offspring health outcomes
Published in Frontiers in pharmacology (06-09-2022)“…This study aimed to analyze the landscape of maternal methylmercury exposure and its offspring consequences based on knowledge mapping of the 100 most-cited…”
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Effects of Fluoride Long-Term Exposure over the Cerebellum: Global Proteomic Profile, Oxidative Biochemistry, Cell Density, and Motor Behavior Evaluation
Published in International journal of molecular sciences (01-10-2020)“…Although the literature does not provide evidence of health risks from exposure to fluoride (F) in therapeutic doses, questions remain about the effects of…”
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Effects of long-term fluoride exposure are associated with oxidative biochemistry impairment and global proteomic modulation, but not genotoxicity, in parotid glands of mice
Published in PloS one (27-01-2022)“…Fluoride has become widely used in dentistry because of its effectiveness in caries control. However, evidence indicates that excessive intake interferes with…”
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Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis
Published in PloS one (30-07-2020)“…Background Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic…”
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From Molecules to Behavior in Long-Term Inorganic Mercury Intoxication: Unraveling Proteomic Features in Cerebellar Neurodegeneration of Rats
Published in International journal of molecular sciences (22-12-2021)“…Mercury is a severe environmental pollutant with neurotoxic effects, especially when exposed for long periods. Although there are several evidences regarding…”
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Intrauterine and Postnatal Exposure to High Levels of Fluoride Is Associated with Motor Impairments, Oxidative Stress, and Morphological Damage in the Cerebellum of Offspring Rats
Published in International journal of molecular sciences (01-08-2022)“…Fluoride (F) is abundantly present on Earth and plays a beneficial role in human health. However, exposure to high doses of F can be a risk, mainly in endemic…”
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Salivary Glands after Prolonged Aluminum Exposure: Proteomic Approach Underlying Biochemical and Morphological Impairments in Rats
Published in International journal of molecular sciences (18-02-2022)“…Aluminum (Al) is one of the most abundant elements on Earth, and its high extraction rate and industrial use make human exposure very common. As Al may be a…”
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Maternal Fluoride Exposure Exerts Different Toxicity Patterns in Parotid and Submandibular Glands of Offspring Rats
Published in International journal of molecular sciences (29-06-2022)“…There is currently a controversial and heated debate about the safety and ethical aspects of fluoride (F) used for human consumption. Thus, this study assessed…”
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