Antioxidant, cytotoxic and antimutagenic activities of 7-epi-clusianone obtained from pericarp of Garcinia brasiliensis

Antioxidant, cytotoxic and antimutagenic activities of 7-epi-clusianone obtained from pericarp of Garcinia brasiliensis

This paper describes the investigation of the cytotoxic and antioxidant activities and in vivo mutagenic/antimutagenic potential of different concentrations of the hexane extract (EHP) and isolated molecule 7-epi-clusianone (MI) of Rheedia brasiliensis. The in vitro antioxidant activity of MI was in...

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Bibliographic Details
Published in:Food research international Vol. 48; no. 1; pp. 180 - 186
Main Authors: Carvalho-Silva, Luciano Bruno, Oliveira, Maysa do Vale, Gontijo, Vanessa Silva, Oliveira, Williana F., Derogis, Priscilla B.M.C., Stringheta, Paulo C., Nagem, Tanus J., Brigagão, Maísa R.P.L., dos Santos, Marcelo H.
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01-08-2012
Elsevier
Subjects:
7-Epi-clusianone
antimutagenic activity
Antioxidant
antioxidant activity
Antioxidants
Artemia
Assessments
Biological and medical sciences
chelates
cytotoxicity
Food industries
Fundamental and applied biological sciences. Psychology
Garcinia
General pharmacology
hexane
In vitro testing
Medical sciences
Medicinal plants
metals
Micronucleus test
monitoring
Mortality
mutagenicity
Mutations
pericarp
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Reduction
Rheedia brasiliensis
Scavenging
Surgical implants
Thymol
Medicinal plants
Mutations
Rheedia brasiliensis
7-Epi-clusianone
Micronucleus test
Antioxidant
Antimutagen
Cytotoxicity
Pericarp
Mutation
Medicinal plant
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Summary:This paper describes the investigation of the cytotoxic and antioxidant activities and in vivo mutagenic/antimutagenic potential of different concentrations of the hexane extract (EHP) and isolated molecule 7-epi-clusianone (MI) of Rheedia brasiliensis. The in vitro antioxidant activity of MI was investigated by monitoring the reduction of radical scavenging and metal chelating activity of DPPH (1,1-diphenyl-2-picryl-hydrazil). Cytotoxic activity was assessed by measuring the mortality of brine shrimp in the presence and absence of the compounds. The mutagenic, antimutagenic and cytotoxic effects of these compounds were evaluated by a micronucleus test. During the antioxidant activity assessment, the 7-epi-clusianone was significantly higher than that of EHP at all concentrations in three assays. From the results obtained with the assessment of cytotoxic activity, all samples had a mortality rate (LC50<100mg/mL) lower than the positive control (thymol). The results of the micronucleus test revealed that MI at 5, 10 and 15mg/kg b.w. is antimutagenic. In conclusion, these results suggest that in the future, the EHP and MI could be used as prophylactic agents in cancer prevention. ► R. brasiliensis hexane extract (EHP) did not show mutagenic effect in mice. ► R. brasiliensis 7-epi-clusianone demonstrated protection against mutagenic effects. ► 7-epi-clusianone at 5, 10 and 15 mg/kg b.w. is antimutagenic. ► 7-epi-clusianone shown might contribute to an anticarcinogenic effect.
Bibliography:http://dx.doi.org/10.1016/j.foodres.2012.03.003
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2012.03.003