Calcium Phosphate-Based Bioceramics in the Treatment of Osteosarcoma: Drug Delivery Composites and Magnetic Hyperthermia Agents

The use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an inte...

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Published in:	Frontiers in medical technology Vol. 3; p. 700266
Main Authors:	Oliveira, Tiê Menezes, Berti, Fernanda Costa Brandão, Gasoto, Sidney Carlos, Schneider, Jr, Bertoldo, Stimamiglio, Marco Augusto, Berti, Lucas Freitas
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 30-06-2021
Subjects:	bioceramic material calcium phosphate drug-delivery systems hydroxyapatite magnetic hyperthermia Medical Technology osteosarcoma hydroxyapatite bioceramic material drug-delivery systems calcium phosphate osteosarcoma magnetic hyperthermia
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Summary:	The use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an interesting bioceramic material. Among its applications, HAp has been used to carry antitumor drugs, such as doxorubicin, cisplatin, and gemcitabine. Such HAp-based composites have an essential role in anticancer drug delivery systems, including the treatment of osteosarcoma. In addition, the association of this bioceramic with magnetic nanoparticles (MNPs) has also been used as an effective agent of local magnetic hyperthermia. Further, the combined approach of the aforementioned techniques (HAp scaffolds combined with anti-tumor drugs and MNPs) is also an attractive therapeutical alternative. Considering the promising role of the use of bioceramics in modern medicine, we proposed this review, presenting an updated perspective on the use of HAp in the treatment of cancer, especially osteosarcoma. Finally, after giving the current progress in this field, we highlight the urgent need for efforts to provide a better understanding of their potential applications.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Marco Augusto Stimamiglio orcid.org/0000-0001-8537-2812 Lucas Freitas Berti orcid.org/0000-0002-9720-9040 Reviewed by: Jay Singh, Banaras Hindu University, India; Purnima Gupta, University of Georgia, United States Bertoldo Schneider Jr. orcid.org/0000-0002-7240-9652 This article was submitted to Nano-Based Drug Delivery, a section of the journal Frontiers in Medical Technology Edited by: Ravindra Pratap Singh, Indira Gandhi National Tribal University, India ORCID: Tiê Menezes Oliveira orcid.org/0000-0002-4069-281X Fernanda Costa Brandão Berti orcid.org/0000-0001-5855-6763 Sidney Carlos Gasoto orcid.org/0000-0003-2380-2981
ISSN:	2673-3129 2673-3129
DOI:	10.3389/fmedt.2021.700266