Average spectral power changes at the hippocampal electroencephalogram in schizophrenia model induced by ketamine

Average spectral power changes at the hippocampal electroencephalogram in schizophrenia model induced by ketamine

The use of ketamine (Ket) as a pharmacological model of schizophrenia is an important tool for understanding the main mechanisms of glutamatergic regulated neural oscillations. Thus, the aim of the current study was to evaluate Ket‐induced changes in the average spectral power using the hippocampal...

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Published in:Fundamental & clinical pharmacology Vol. 32; no. 1; pp. 60 - 68
Main Authors: Sampaio, Luis Rafael L., Borges, Lucas T.N., Silva, Joyse M.F., Andrade, Francisca Roselin O., Barbosa, Talita M., Oliveira, Tatiana Q., Macedo, Danielle, Lima, Ricardo F., Dantas, Leonardo P., Patrocinio, Manoel Cláudio A., Vale, Otoni C., Vasconcelos, Silvânia M.M.
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01-02-2018
Subjects:
Animal models
EEG
electroencephalogram
Electroencephalography
Glutamatergic transmission
Hippocampus
Implantation
Ketamine
Mental disorders
Oscillations
Pharmacology
Rats
Rodents
Schizophrenia
Spectra
spectral analysis
Surgery
Waves
spectral analysis
schizophrenia
hippocampus
ketamine
electroencephalogram
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Summary:The use of ketamine (Ket) as a pharmacological model of schizophrenia is an important tool for understanding the main mechanisms of glutamatergic regulated neural oscillations. Thus, the aim of the current study was to evaluate Ket‐induced changes in the average spectral power using the hippocampal quantitative electroencephalography (QEEG). To this end, male Wistar rats were submitted to a stereotactic surgery for the implantation of an electrode in the right hippocampus. After three days, the animals were divided into four groups that were treated for 10 consecutive days with Ket (10, 50, or 100 mg/kg). Brainwaves were captured on the 1st or 10th day, respectively, to acute or repeated treatments. The administration of Ket (10, 50, or 100 mg/kg), compared with controls, induced changes in the hippocampal average spectral power of delta, theta, alpha, gamma low or high waves, after acute or repeated treatments. Therefore, based on the alterations in the average spectral power of hippocampal waves induced by Ket, our findings might provide a basis for the use of hippocampal QEEG in animal models of schizophrenia.
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ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12319