The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto

Abstract Purpose to study 75 familial adenomatous polyposis (FAP) patients treated in a single insti- tution in Ribeirão Preto/SP, from January 1981 to December 2011. Methods this is a retrospective study and the following data were collected: gender, age, main symptoms, familial history, coexisting...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of Coloproctology Vol. 33; no. 3; pp. 126 - 130
Main Authors:	Feitosa, Marley Ribeiro, Oliveira, Tais Helena Garcia Fernandes de, Kondo, Bruno Ravenna Pinheiro, Lira, Haline Gomes de, Abissamra, André Antonio, Parra, Rogério Serafim, Féres, Omar, Rocha, Jose Joaquim Ribeiro da
Format:	Journal Article
Language:	English
Published:	Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Elsevier Editora Ltda 01-09-2013 Thieme Revinter Publicações Ltda
Subjects:	Bolsa ileal Familial adenomatous polyposis Colorectal cancer Gastroenterology and Hepatology Ileal pouch Original article Polipose adenomatosa familiar Câncer colorretal Familial adenomatous polyposis Colorectal cancer Polipose adenomatosa familiar Câncer colorretal Ileal pouch Bolsa ileal
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Purpose to study 75 familial adenomatous polyposis (FAP) patients treated in a single insti- tution in Ribeirão Preto/SP, from January 1981 to December 2011. Methods this is a retrospective study and the following data were collected: gender, age, main symptoms, familial history, coexisting malignancies, surgical treatment, surgical morbidity and mortality, factors related to life quality. Results median age was 29 years. Male-to-female ratio was 1.2:1. Bleeding was the most common symptom (62.6%). Colorectal cancer incidence was 25.5% (n = 19). Extracolonic neoplasia incidence was 8%. Colectomy with ileorectal anastomosis (IRA) was performed in 72% of the patients. Eighteen patients (24%) were submitted to proctocolectomy with “J-pouch” ileoanal anastomosis. In three patients (4%) proctocolectomy with terminal il- eostomy was performed. Early and late complication rate were similar (22.7% × 24%). Ileal pouch surgery exhibited tendency to a higher morbidity and mortality but no significance could be found. Overall mortality rate was 7.46%. Malignant neoplasia was the main cause of mortality, accounting for 60% of deaths. Conclusion FAP is a rare pathology in our country. Genetic counseling and proper screening programs are essential tools to early diagnosis and follow-up. Surgery is the most effective treatment and the best option to prevent malignant neoplasia.
ISSN:	2237-9363 2317-6423
DOI:	10.1016/j.jcol.2013.06.003