Case Report: Microcephaly in Twins due to the Zika Virus

Recent studies have demonstrated an association between congenital Zika virus (ZIKV) infection and microcephaly; however, to date, there have been no reports on the consequences of ZIKV infection on fetuses in twin pregnancies. Herein, we reported on the first case of a monochorionic diamniotic (MCD...

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Bibliographic Details
Published in:	The American journal of tropical medicine and hygiene Vol. 97; no. 1; pp. 151 - 154
Main Authors:	Santos, Victor S, Oliveira, Sheila J G, Gurgel, Ricardo Q, Lima, Dorothy R R, Dos Santos, Cliomar A, Martins-Filho, Paulo R S
Format:	Journal Article
Language:	English
Published:	United States The American Society of Tropical Medicine and Hygiene 01-07-2017
Subjects:	Adolescent Diseases in Twins - virology Exotropia - congenital Exotropia - etiology Exotropia - pathology Female Humans Infant, Newborn Microcephaly - virology Pregnancy Pregnancy Complications, Infectious - virology Zika Virus Infection - complications Zika Virus Infection - congenital
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Summary:	Recent studies have demonstrated an association between congenital Zika virus (ZIKV) infection and microcephaly; however, to date, there have been no reports on the consequences of ZIKV infection on fetuses in twin pregnancies. Herein, we reported on the first case of a monochorionic diamniotic (MCDA) twin pregnancy having ZIKV-related microcephaly. Our findings suggested that, in an MCDA twin pregnancy, the ZIKV may cause infection in both fetuses, resulting in severe abnormalities in the central nervous system due to neural cell destruction and the disruption of the normal development processes of the brain. This case report and other similar twin cases may help to understand the pathogenesis and to confirm the etiology of ZIKV as a teratogenic microorganism.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Authors’ addresses: Victor S. Santos, Sheila J. G. Oliveira, Ricardo Q. Gurgel, Dorothy R. R. Lima, and Paulo R. S. Martins-Filho, Federal University of Sergipe, Aracaju, Brazil, E-mails: santosvictor19@gmail.com, sheilajgsoliveira@gmail.com, ricardoqgurgel@gmail.com, dorothyribeiro@hotmail.com, and martins-filho@ufs.br. Cliomar A. dos Santos, Central Public Health Laboratory, Aracaju, Brazil, E-mail: cliomar.santos@fsph.se.gov.br.
ISSN:	0002-9637 1476-1645 1476-1645
DOI:	10.4269/ajtmh.16-1021