Search Results - "Oliveira, Paulo Sergio Lopes de"

Featuring the nucleosome surface as a therapeutic target by Silva, Isabel Torres Gomes da, Oliveira, Paulo Sergio Lopes de, Santos, Guilherme Martins

“…Highlights • Chromatin dynamics depend on competition by NBPs and the histone H4 tail to bind to the nucleosome's acidic patch. • eNBMs and distinct NBPs lead…”
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Genes Controlled by DNA Methylation Are Involved in Wilms Tumor Progression by Guerra, João Victor da Silva, Pereira, Bruna Maria de Sá, Cruz, Jéssica Gonçalves Vieira da, Scherer, Nicole de Miranda, Furtado, Carolina, Montalvão de Azevedo, Rafaela, Oliveira, Paulo Sergio Lopes de, Faria, Paulo, Boroni, Mariana, de Camargo, Beatriz, Maschietto, Mariana

“…To identify underlying mechanisms involved with metastasis formation in Wilms tumors (WTs), we performed comprehensive DNA methylation and gene expression…”
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Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability by de Oliveira, Juliana Ferreira, do Prado, Paula Favoretti Vital, da Costa, Silvia Souza, Sforça, Mauricio Luis, Canateli, Camila, Ranzani, Americo Tavares, Maschietto, Mariana, de Oliveira, Paulo Sergio Lopes, Otto, Paulo A., Klevit, Rachel E., Krepischi, Ana Cristina Victorino, Rosenberg, Carla, Franchini, Kleber Gomes

“…Ubiquitin-conjugating enzymes (E2) enable protein ubiquitination by conjugating ubiquitin to their catalytic cysteine for subsequent transfer to a target…”
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Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity by Moraes, Eduardo Cruz, Meirelles, Gabriela Vaz, Honorato, Rodrigo Vargas, de Souza, Tatiana de Arruda Campos Brasil, de Souza, Edmarcia Elisa, Murakami, Mario Tyago, de Oliveira, Paulo Sergio Lopes, Kobarg, Jörg

“…Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the…”
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Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases by Duarte, Mariana Lemos, Pena, Darlene Aparecida, Nunes Ferraz, Felipe Augusto, Berti, Denise Aparecida, Paschoal Sobreira, Tiago José, Costa-Junior, Helio Miranda, Abdel Baqui, Munira Muhammad, Disatnik, Marie-Hélène, Xavier-Neto, José, Lopes de Oliveira, Paulo Sérgio, Schechtman, Deborah

“…Linear consensus motifs are short contiguous sequences of residues within a protein that can form recognition modules for protein interaction or catalytic…”
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Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO) by Alborghetti, Marcos Rodrigo, Furlan, Ariane da Silva, da Silva, Júlio César, Sforça, Maurício Luís, Honorato, Rodrigo Vargas, Granato, Daniela Campos, dos Santos Migueleti, Deivid Lucas, Neves, Jorge L, de Oliveira, Paulo Sergio Lopes, Paes-Leme, Adriana Franco, Zeri, Ana Carolina de Mattos, de Torriani, Iris Concepcion Linares, Kobarg, Jörg

“…Cytoskeleton and protein trafficking processes, including vesicle transport to synapses, are key processes in neuronal differentiation and axon outgrowth. The…”
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Oligomerization as a strategy for cold adaptation: Structure and dynamics of the GH1 β-glucosidase from Exiguobacterium antarcticum B7 by Zanphorlin, Leticia Maria, de Giuseppe, Priscila Oliveira, Honorato, Rodrigo Vargas, Tonoli, Celisa Caldana Costa, Fattori, Juliana, Crespim, Elaine, de Oliveira, Paulo Sergio Lopes, Ruller, Roberto, Murakami, Mario Tyago

“…Psychrophilic enzymes evolved from a plethora of structural scaffolds via multiple molecular pathways. Elucidating their adaptive strategies is instrumental to…”
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Improving obesity research: Unveiling metabolic pathways through a 3D In vitro model of adipocytes using 3T3-L1 cells by Avelino, Thayna Mendonca, Provencio, Marta García-Arévalo, Peroni, Luis Antonio, Domingues, Romênia Ramos, Torres, Felipe Rafael, de Oliveira, Paulo Sergio Lopes, Leme, Adriana Franco Paes, Figueira, Ana Carolina Migliorini

“…Obesity, a burgeoning global health crisis, has tripled in prevalence over the past 45 years, necessitating innovative research methodologies. Adipocytes,…”
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Structural dynamics of SARS-CoV-2 nucleocapsid protein induced by RNA binding by Ribeiro-Filho, Helder Veras, Jara, Gabriel Ernesto, Batista, Fernanda Aparecida Heleno, Schleder, Gabriel Ravanhani, Costa Tonoli, Celisa Caldana, Soprano, Adriana Santos, Guimarães, Samuel Leite, Borges, Antonio Carlos, Cassago, Alexandre, Bajgelman, Marcio Chaim, Marques, Rafael Elias, Trivella, Daniela Barretto Barbosa, Franchini, Kleber Gomes, Figueira, Ana Carolina Migliorini, Benedetti, Celso Eduardo, Lopes-de-Oliveira, Paulo Sergio

“…The nucleocapsid (N) protein of the SARS-CoV-2 virus, the causal agent of COVID-19, is a multifunction phosphoprotein that plays critical roles in the virus…”
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pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data science by Guerra, João Victor da Silva, Ribeiro-Filho, Helder Veras, Jara, Gabriel Ernesto, Bortot, Leandro Oliveira, Pereira, José Geraldo de Carvalho, Lopes-de-Oliveira, Paulo Sérgio

“…Biomolecular interactions that modulate biological processes occur mainly in cavities throughout the surface of biomolecular structures. In the data science…”
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DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ by Pramio, Dimitrius Tansini, Vieceli, Felipe Monteleone, Varella-Branco, Elisa, Goes, Carolina Purcell, Kobayashi, Gerson Shigeru, da Silva Pelegrina, Diogo Vieira, de Moraes, Beatriz Caroline, El Allam, Aicha, De Kumar, Bony, Jara, Gabriel, Farfel, José Marcelo, Bennett, David Alan, Kundu, Somanath, Viapiano, Mariano S., Reis, Eduardo Moraes, de Oliveira, Paulo Sergio Lopes, dos Santos e Passos-Bueno, Maria Rita, Rothlin, Carla V., Ghosh, Sourav, Schechtman, Deborah

“…Protein kinase M zeta, PKMζ, is a brain enriched kinase with a well characterized role in Long-Term Potentiation (LTP), the activity-dependent strengthening of…”
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Molecular Mechanisms Associated with Xylan Degradation by Xanthomonas Plant Pathogens by Santos, Camila Ramos, Hoffmam, Zaira Bruna, de Matos Martins, Vanesa Peixoto, Zanphorlin, Leticia Maria, de Paula Assis, Leandro Henrique, Honorato, Rodrigo Vargas, Lopes de Oliveira, Paulo Sérgio, Ruller, Roberto, Murakami, Mario Tyago

“…Xanthomonas pathogens attack a variety of economically relevant plants, and their xylan CUT system (carbohydrate utilization with TonB-dependent outer membrane…”
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The mechanism by which a distinguishing arabinofuranosidase can cope with internal di-substitutions in arabinoxylans by Dos Santos, Camila Ramos, de Giuseppe, Priscila Oliveira, de Souza, Flávio Henrique Moreira, Zanphorlin, Letícia Maria, Domingues, Mariane Noronha, Pirolla, Renan Augusto Siqueira, Honorato, Rodrigo Vargas, Tonoli, Celisa Caldana Costa, de Morais, Mariana Abrahão Bueno, de Matos Martins, Vanesa Peixoto, Fonseca, Lucas Miranda, Büchli, Fernanda, de Oliveira, Paulo Sergio Lopes, Gozzo, Fábio Cesar, Murakami, Mário Tyago

“…Arabinoxylan is an abundant polysaccharide in industrially relevant biomasses such as sugarcane, corn stover and grasses. However, the arabinofuranosyl…”
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Glutaminase Affects the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor γ (PPARγ) via Direct Interaction by de Guzzi Cassago, Carolina Aparecida, Dias, Marília Meira, Pinheiro, Matheus Pinto, Pasquali, Camila Cristina, Bastos, Alliny Cristiny Silva, Islam, Zeyaul, Consonni, Sílvio Roberto, de Oliveira, Juliana Ferreira, Gomes, Emerson Machi, Ascenção, Carolline Fernanda Rodrigues, Honorato, Rodrigo, Pauletti, Bianca Alves, Indolfo, Nathalia de Carvalho, Filho, Helder Veras Ribeiro, de Oliveira, Paulo Sergio Lopes, Figueira, Ana Carolina Migliorini, Paes Leme, Adriana Franco, Ambrosio, Andre Luis Berteli, Dias, Sandra Martha Gomes

“…Phosphate-activated glutaminases catalyze the deamidation of glutamine to glutamate and play key roles in several physiological and pathological processes. In…”
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Vasodilator effects and putative guanylyl cyclase stimulation by 2-nitro-1-phenylethanone and 2-nitro-2-phenyl-propane-1,3-diol on rat aorta by Vasconcelos, Thiago Brasileiro de, Ribeiro-Filho, Helder Veras, Lahlou, Saad, Pereira, José Geraldo de Carvalho, Oliveira, Paulo Sérgio Lopes de, Magalhães, Pedro Jorge Caldas

“…Compounds containing a nitro group may reveal vasodilator properties. Several nitro compounds have a NO2 group in a short aliphatic chain connected to an…”
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Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study by Xavier-Neto, Jose, Carvalho, Murilo, Pascoalino, Bruno Dos Santos, Cardoso, Alisson Campos, Costa, Ângela Maria Sousa, Pereira, Ana Helena Macedo, Santos, Luana Nunes, Saito, Ângela, Marques, Rafael Elias, Smetana, Juliana Helena Costa, Consonni, Silvio Roberto, Bandeira, Carla, Costa, Vivian Vasconcelos, Bajgelman, Marcio Chaim, de Oliveira, Paulo Sérgio Lopes, Cordeiro, Marli Tenorio, Gonzales Gil, Laura Helena Vega, Pauletti, Bianca Alves, Granato, Daniela Campos, Paes Leme, Adriana Franco, Freitas-Junior, Lucio, Holanda de Freitas, Carolina Borsoi Moraes, Teixeira, Mauro Martins, Bevilacqua, Estela, Franchini, Kleber

“…The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental…”
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Structure and Mechanism of Dimer–Monomer Transition of a Plant Poly(A)-Binding Protein upon RNA Interaction: Insights into Its Poly(A) Tail Assembly by Domingues, Mariane Noronha, Sforça, Mauricio Luis, Soprano, Adriana Santos, Lee, Jack, de Souza, Tatiana de Arruda Campos Brasil, Cassago, Alexandre, Portugal, Rodrigo Villares, de Mattos Zeri, Ana Carolina, Murakami, Mario Tyago, Sadanandom, Ari, de Oliveira, Paulo Sergio Lopes, Benedetti, Celso Eduardo

“…Poly(A)-binding proteins (PABPs) play crucial roles in mRNA biogenesis, stability, transport and translational control in most eukaryotic cells. Although…”
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SpliceProt: A protein sequence repository of predicted human splice variants by Tavares, Raphael, de Miranda Scherer, Nicole, Pauletti, Bianca Alves, Araújo, Elói, Folador, Edson Luiz, Espindola, Gabriel, Ferreira, Carlos Gil, Paes Leme, Adriana Franco, de Oliveira, Paulo Sergio Lopes, Passetti, Fabio

“…The mechanism of alternative splicing in the transcriptome may increase the proteome diversity in eukaryotes. In proteomics, several studies aim to use protein…”
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Rational design and validation of an anti-protein kinase C active-state specific antibody based on conformational changes by Pena, Darlene Aparecida, Andrade, Victor Piana de, Silva, Gabriela Ávila Fernandes, Neves, José Ivanildo, Oliveira, Paulo Sergio Lopes de, Alves, Maria Julia Manso, Devi, Lakshmi A., Schechtman, Deborah

“…Protein kinase C (PKC) plays a regulatory role in key pathways in cancer. However, since phosphorylation is a step for classical PKC (cPKC) maturation and does…”
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ParKVFinder: A thread-level parallel approach in biomolecular cavity detection by Guerra, João Victor da Silva, Ribeiro Filho, Helder Veras, Bortot, Leandro Oliveira, Honorato, Rodrigo Vargas, Pereira, José Geraldo de Carvalho, Lopes-de-Oliveira, Paulo Sérgio

“…Biological processes are regulated mainly by the binding of small molecules into cavities distributed throughout the biomolecular structure. Computational…”
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