Search Results - "Oliveira, Paulo Sérgio Lopes de"

Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases by Duarte, Mariana Lemos, Pena, Darlene Aparecida, Nunes Ferraz, Felipe Augusto, Berti, Denise Aparecida, Paschoal Sobreira, Tiago José, Costa-Junior, Helio Miranda, Abdel Baqui, Munira Muhammad, Disatnik, Marie-Hélène, Xavier-Neto, José, Lopes de Oliveira, Paulo Sérgio, Schechtman, Deborah

“…Linear consensus motifs are short contiguous sequences of residues within a protein that can form recognition modules for protein interaction or catalytic…”
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pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data science by Guerra, João Victor da Silva, Ribeiro-Filho, Helder Veras, Jara, Gabriel Ernesto, Bortot, Leandro Oliveira, Pereira, José Geraldo de Carvalho, Lopes-de-Oliveira, Paulo Sérgio

“…Biomolecular interactions that modulate biological processes occur mainly in cavities throughout the surface of biomolecular structures. In the data science…”
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Molecular Mechanisms Associated with Xylan Degradation by Xanthomonas Plant Pathogens by Santos, Camila Ramos, Hoffmam, Zaira Bruna, de Matos Martins, Vanesa Peixoto, Zanphorlin, Leticia Maria, de Paula Assis, Leandro Henrique, Honorato, Rodrigo Vargas, Lopes de Oliveira, Paulo Sérgio, Ruller, Roberto, Murakami, Mario Tyago

“…Xanthomonas pathogens attack a variety of economically relevant plants, and their xylan CUT system (carbohydrate utilization with TonB-dependent outer membrane…”
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Vasodilator effects and putative guanylyl cyclase stimulation by 2-nitro-1-phenylethanone and 2-nitro-2-phenyl-propane-1,3-diol on rat aorta by Vasconcelos, Thiago Brasileiro de, Ribeiro-Filho, Helder Veras, Lahlou, Saad, Pereira, José Geraldo de Carvalho, Oliveira, Paulo Sérgio Lopes de, Magalhães, Pedro Jorge Caldas

“…Compounds containing a nitro group may reveal vasodilator properties. Several nitro compounds have a NO2 group in a short aliphatic chain connected to an…”
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Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study by Xavier-Neto, Jose, Carvalho, Murilo, Pascoalino, Bruno Dos Santos, Cardoso, Alisson Campos, Costa, Ângela Maria Sousa, Pereira, Ana Helena Macedo, Santos, Luana Nunes, Saito, Ângela, Marques, Rafael Elias, Smetana, Juliana Helena Costa, Consonni, Silvio Roberto, Bandeira, Carla, Costa, Vivian Vasconcelos, Bajgelman, Marcio Chaim, de Oliveira, Paulo Sérgio Lopes, Cordeiro, Marli Tenorio, Gonzales Gil, Laura Helena Vega, Pauletti, Bianca Alves, Granato, Daniela Campos, Paes Leme, Adriana Franco, Freitas-Junior, Lucio, Holanda de Freitas, Carolina Borsoi Moraes, Teixeira, Mauro Martins, Bevilacqua, Estela, Franchini, Kleber

“…The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental…”
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ParKVFinder: A thread-level parallel approach in biomolecular cavity detection by Guerra, João Victor da Silva, Ribeiro Filho, Helder Veras, Bortot, Leandro Oliveira, Honorato, Rodrigo Vargas, Pereira, José Geraldo de Carvalho, Lopes-de-Oliveira, Paulo Sérgio

“…Biological processes are regulated mainly by the binding of small molecules into cavities distributed throughout the biomolecular structure. Computational…”
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Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties by Ribeiro Filho, Helder Veras, Bernardi Videira, Natália, Bridi, Aline Villanova, Tittanegro, Thais Helena, Helena Batista, Fernanda Aparecida, de Carvalho Pereira, José Geraldo, de Oliveira, Paulo Sérgio Lopes, Bajgelman, Marcio Chaim, Le Maire, Albane, Figueira, Ana Carolina Migliorini

“…Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcription factor,…”
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Featuring the nucleosome surface as a therapeutic target by Silva, Isabel Torres Gomes da, Oliveira, Paulo Sergio Lopes de, Santos, Guilherme Martins

“…Highlights • Chromatin dynamics depend on competition by NBPs and the histone H4 tail to bind to the nucleosome's acidic patch. • eNBMs and distinct NBPs lead…”
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Genes Controlled by DNA Methylation Are Involved in Wilms Tumor Progression by Guerra, João Victor da Silva, Pereira, Bruna Maria de Sá, Cruz, Jéssica Gonçalves Vieira da, Scherer, Nicole de Miranda, Furtado, Carolina, Montalvão de Azevedo, Rafaela, Oliveira, Paulo Sergio Lopes de, Faria, Paulo, Boroni, Mariana, de Camargo, Beatriz, Maschietto, Mariana

“…To identify underlying mechanisms involved with metastasis formation in Wilms tumors (WTs), we performed comprehensive DNA methylation and gene expression…”
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Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses by Ribeiro-Filho, Helder V., Coimbra, Lais D., Cassago, Alexandre, Rocha, Rebeca P. F., Guerra, João Victor da Silva, de Felicio, Rafael, Carnieli, Carolina Moretto, Leme, Luiza, Padilha, Antonio Cláudio, Paes Leme, Adriana F., Trivella, Daniela B. B., Portugal, Rodrigo Villares, Lopes-de-Oliveira, Paulo Sérgio, Marques, Rafael Elias

“…Mayaro virus (MAYV) is an emerging arbovirus of the Americas that may cause a debilitating arthritogenic disease. The biology of MAYV is not fully understood…”
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Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor by Mercaldi, Gustavo Fernando, Bezerra, Eduardo Henrique Salviano, Batista, Fernanda Aparecida Heleno, Tonoli, Celisa Caldana Costa, Soprano, Adriana Santos, Shimizu, Jacqueline Farinha, Nagai, Alice, da Silva, Jaqueline Cristina, Filho, Helder Veras Ribeiro, do Nascimento Faria, Jéssica, da Cunha, Marcos Guilherme, Zeri, Ana Carolina Mattos, Nascimento, Andrey Fabricio Ziem, Proenca-Modena, José Luiz, Bajgelman, Marcio Chaim, Rocco, Silvana Aparecida, Lopes-de-Oliveira, Paulo Sérgio, Cordeiro, Artur Torres, Bruder, Marjorie, Marques, Rafael Elias, Sforça, Mauricio Luis, Franchini, Kleber Gomes, Benedetti, Celso Eduardo, Figueira, Ana Carolina Migliorini, Trivella, Daniela Barretto Barbosa

“…The nucleocapsid (N) protein plays critical roles in coronavirus genome transcription and packaging, representing a key target for the development of novel…”
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Crystal Structure and Regulation of the Citrus Pol III Repressor MAF1 by Auxin and Phosphorylation by Soprano, Adriana Santos, Giuseppe, Priscila Oliveira de, Shimo, Hugo Massayoshi, Lima, Tatiani Brenelli, Batista, Fernanda Aparecida Heleno, Righetto, Germanna Lima, Pereira, José Geraldo de Carvalho, Granato, Daniela Campos, Nascimento, Andrey Fabricio Ziem, Gozzo, Fabio Cesar, de Oliveira, Paulo Sérgio Lopes, Figueira, Ana Carolina Migliorini, Smetana, Juliana Helena Costa, Paes Leme, Adriana Franco, Murakami, Mario Tyago, Benedetti, Celso Eduardo

“…MAF1 is the main RNA polymerase (Pol) III repressor that controls cell growth in eukaryotes. The Citrus ortholog, CsMAF1, was shown to restrict cell growth in…”
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Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability by de Oliveira, Juliana Ferreira, do Prado, Paula Favoretti Vital, da Costa, Silvia Souza, Sforça, Mauricio Luis, Canateli, Camila, Ranzani, Americo Tavares, Maschietto, Mariana, de Oliveira, Paulo Sergio Lopes, Otto, Paulo A., Klevit, Rachel E., Krepischi, Ana Cristina Victorino, Rosenberg, Carla, Franchini, Kleber Gomes

“…Ubiquitin-conjugating enzymes (E2) enable protein ubiquitination by conjugating ubiquitin to their catalytic cysteine for subsequent transfer to a target…”
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Negative regulation of bacterial killing and inflammation by two novel CD16 ligands by Beppler, Jaqueline, Mkaddem, Sanae Ben, Michaloski, Jussara, Honorato, Rodrigo Vargas, Velasco, Irineu Tadeu, Oliveira, Paulo Sérgio Lopes, Giordano, Ricardo José, Monteiro, Renato C., Pinheiro da Silva, Fabiano

“…Sepsis, a leading cause of death worldwide, involves exacerbated proinflammatory responses and inefficient bacterial clearance. Phagocytic cells play a crucial…”
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Gallic acid modulates phenotypic behavior and gene expression in oral squamous cell carcinoma cells by interfering with leptin pathway by Santos, Eliane Macedo Sobrinho, da Rocha, Rogério Gonçalves, Santos, Hércules Otacílio, Guimarães, Talita Antunes, de Carvalho Fraga, Carlos Alberto, da Silveira, Luiz Henrique, Batista, Paulo Ricardo, de Oliveira, Paulo Sérgio Lopes, Melo, Geraldo Aclécio, Santos, Sérgio Henrique, de Paula, Alfredo Maurício Batista, Guimarães, André Luiz Sena, Farias, Lucyana Conceição

“…Gallic acid is a polyphenolic compost appointed to interfere with neoplastic cells behavior. Evidence suggests an important role of leptin in carcinogenesis…”
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Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity by Moraes, Eduardo Cruz, Meirelles, Gabriela Vaz, Honorato, Rodrigo Vargas, de Souza, Tatiana de Arruda Campos Brasil, de Souza, Edmarcia Elisa, Murakami, Mario Tyago, de Oliveira, Paulo Sergio Lopes, Kobarg, Jörg

“…Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the…”
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Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO) by Alborghetti, Marcos Rodrigo, Furlan, Ariane da Silva, da Silva, Júlio César, Sforça, Maurício Luís, Honorato, Rodrigo Vargas, Granato, Daniela Campos, dos Santos Migueleti, Deivid Lucas, Neves, Jorge L, de Oliveira, Paulo Sergio Lopes, Paes-Leme, Adriana Franco, Zeri, Ana Carolina de Mattos, de Torriani, Iris Concepcion Linares, Kobarg, Jörg

“…Cytoskeleton and protein trafficking processes, including vesicle transport to synapses, are key processes in neuronal differentiation and axon outgrowth. The…”
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Oligomerization as a strategy for cold adaptation: Structure and dynamics of the GH1 β-glucosidase from Exiguobacterium antarcticum B7 by Zanphorlin, Leticia Maria, de Giuseppe, Priscila Oliveira, Honorato, Rodrigo Vargas, Tonoli, Celisa Caldana Costa, Fattori, Juliana, Crespim, Elaine, de Oliveira, Paulo Sergio Lopes, Ruller, Roberto, Murakami, Mario Tyago

“…Psychrophilic enzymes evolved from a plethora of structural scaffolds via multiple molecular pathways. Elucidating their adaptive strategies is instrumental to…”
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Improving obesity research: Unveiling metabolic pathways through a 3D In vitro model of adipocytes using 3T3-L1 cells by Avelino, Thayna Mendonca, Provencio, Marta García-Arévalo, Peroni, Luis Antonio, Domingues, Romênia Ramos, Torres, Felipe Rafael, de Oliveira, Paulo Sergio Lopes, Leme, Adriana Franco Paes, Figueira, Ana Carolina Migliorini

“…Obesity, a burgeoning global health crisis, has tripled in prevalence over the past 45 years, necessitating innovative research methodologies. Adipocytes,…”
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Structural dynamics of SARS-CoV-2 nucleocapsid protein induced by RNA binding by Ribeiro-Filho, Helder Veras, Jara, Gabriel Ernesto, Batista, Fernanda Aparecida Heleno, Schleder, Gabriel Ravanhani, Costa Tonoli, Celisa Caldana, Soprano, Adriana Santos, Guimarães, Samuel Leite, Borges, Antonio Carlos, Cassago, Alexandre, Bajgelman, Marcio Chaim, Marques, Rafael Elias, Trivella, Daniela Barretto Barbosa, Franchini, Kleber Gomes, Figueira, Ana Carolina Migliorini, Benedetti, Celso Eduardo, Lopes-de-Oliveira, Paulo Sergio

“…The nucleocapsid (N) protein of the SARS-CoV-2 virus, the causal agent of COVID-19, is a multifunction phosphoprotein that plays critical roles in the virus…”
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