Search Results - "Oliveira, Monica Cristina"

Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model by de Oliveira Silva, Juliana, Fernandes, Renata Salgado, Ramos Oda, Caroline Mari, Ferreira, Tiago Hilário, Machado Botelho, Ana Flávia, Martins Melo, Marília, de Miranda, Marcelo Coutinho, Assis Gomes, Dawidson, Dantas Cassali, Geovanni, Townsend, Danyelle M., Rubello, Domenico, Oliveira, Mônica Cristina, de Barros, André Luís Branco

“…Long circulating pH-sensitive liposomes have been shown to effectively deliver doxorubicin (DOX) to tumors and reduce its toxic effects. Folic acid receptors…”
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pH-responsive and folate-coated liposomes encapsulating irinotecan as an alternative to improve efficacy of colorectal cancer treatment by Nunes, Shirleide Santos, Miranda, Sued Eustaquio Mendes, de Oliveira Silva, Juliana, Fernandes, Renata Salgado, de Alcântara Lemos, Janaína, de Aguiar Ferreira, Carolina, Townsend, Danyelle M., Cassali, Geovanni Dantas, Oliveira, Mônica Cristina, Branco de Barros, André Luís

“…Irinotecan (IRN) is a semisynthetic derivative of camptothecin that acts as a topoisomerase I inhibitor. IRN is used worldwide for the treatment of several…”
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Combination of the Topical Photodynamic Therapy of Chloroaluminum Phthalocyanine Liposomes with Fexinidazole Oral Self-Emulsifying System as a New Strategy for Cutaneous Leishmaniasis Treatment by Silva, Raphaela Ariany, Damasio, Danielle Soter, Coelho, Larissa Dutra, de Morais-Teixeira, Eliane, Queiroz-Junior, Celso M, Souza, Paulo Eduardo, Azevedo, Ricardo Bentes, Tedesco, Antônio, Ferreira, Lucas Antônio, Oliveira, Mônica Cristina, Aguiar, Marta Gontijo

“…Cutaneous leishmaniasis (CL) is a neglected tropical disease. The treatment is restricted to drugs, such as meglumine antimoniate and amphotericin B, that…”
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PEGylated versus Non-PEGylated pH-Sensitive Liposomes: New Insights from a Comparative Antitumor Activity Study by Nunes, Shirleide Santos, de Oliveira Silva, Juliana, Fernandes, Renata Salgado, Miranda, Sued Eustaquio Mendes, Leite, Elaine Amaral, de Farias, Marcelo Alexandre, Portugal, Rodrigo Villares, Cassali, Geovanni Dantas, Townsend, Danyelle M, Oliveira, Mônica Cristina, de Barros, André Luís Branco

“…PEGylated liposomes are largely studied as long-circulating drug delivery systems. Nevertheless, the addition of PEG can result in reduced interactions between…”
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Physicochemical Characterization and Skin Permeation of Cationic Transfersomes Containing the Synthetic Peptide PnPP-19 by De Marco Almeida, Flavia, Silva, Carolina Nunes, de Araujo Lopes, Savia Caldeira, Santos, Daniel Moreira, Torres, Fernanda Silva, Cardoso, Felipe Lima, Martinelli, Patricia Massara, da Silva, Elizabeth Ribeiro, de Lima, Maria Elena, Miranda, Lucas Antonio Ferreira, Oliveira, Monica Cristina

“…PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. The aim of this work was to…”
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Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment by Franco, Marina Santiago, Gomes, Eliza Rocha, Roque, Marjorie Coimbra, Oliveira, Mônica Cristina

“…Since more than 40 years liposomes have being extensively studied for their potential as carriers of anticancer drugs. The basic principle behind their use for…”
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Investigation of the antitumor activity and toxicity of long-circulating and fusogenic liposomes co-encapsulating paclitaxel and doxorubicin in a murine breast cancer animal model by Franco, Marina Santiago, Roque, Marjorie Coimbra, de Barros, André Luís Branco, de Oliveira Silva, Juliana, Cassali, Geovanni Dantas, Oliveira, Mônica Cristina

“…[Display omitted] •Treatment of murine breast cancer with LCFL-PTX/DXR is superior to treatments with free PTX or free DXR.•No heart damage is observed when…”
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The effect of free and encapsulated cisplatin into long-circulating and pH-sensitive liposomes on IEC-6 cells during wound healing in the presence of host–microbiota by Araújo, Raquel Silva, Cristina Oliveira, Mônica, Cardoso, Valbert Nascimento, Keefe, Dorothy M K, Stringer, Andrea M

“…Abstract Objectives To circumvent cisplatin (CDDP) toxic effects and improve the antitumoural effect, our research group developed long-circulating and…”
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Physical and biological effects of paclitaxel encapsulation on disteraroylphosphatidylethanolamine-polyethyleneglycol polymeric micelles by Oda, Caroline Mari Ramos, Malfatti-Gasperini, Antônio Augusto, Malachias, Angelo, Pound-Lana, Gwenaelle, Mosqueira, Vanessa Carla Furtado, Fernandes, Renata Salgado, Oliveira, Mônica Cristina de, de Barros, André Luis Branco, Leite, Elaine Amaral

“…[Display omitted] •SAXS analysis showed that encapsulation of paclitaxel affected the micelle packing.•Core radius increased while shell radius shrank, without…”
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Evaluation of acute toxicity and in vitro antitumor activity of a novel doxorubicin-loaded folate-coated pH-sensitive liposome by de Oliveira Silva, Juliana, Fernandes, Renata Salgado, de Alcântara Lemos, Janaína, Cassali, Geovanni Dantas, de Paula Sabino, Adriano, Townsend, Danyelle M., Oliveira, Mônica Cristina, de Barros, André Luís Branco

“…Doxorubicin (DOX) loaded liposomes have been used and studied in the last decades due to the significant decrease in DOX induced cardiac and systemic toxicity…”
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Paclitaxel-Loaded Folate-Coated pH-Sensitive Liposomes Enhance Cellular Uptake and Antitumor Activity by Monteiro, Liziane O. F, Fernandes, Renata S, Castro, Luciano, Reis, Diego, Cassali, Geovanni D, Evangelista, Fernanda, Loures, Cristina, Sabino, Adriano P, Cardoso, Valbert, Oliveira, Mônica Cristina, Branco de Barros, André, Leite, Elaine A

“…Paclitaxel (PTX) is a microtubule-stabilizing agent widely used to treat breast cancer. Nevertheless, the low solubility of the drug and the side effects of…”
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Preclinical toxicological study of long-circulating and fusogenic liposomes co-encapsulating paclitaxel and doxorubicin in synergic ratio by Roque, Marjorie Coimbra, da Silva, Caroline Dohanik, Lempek, Marthin Raboch, Cassali, Geovanni Dantas, de Barros, André Luís Branco, Melo, Marília Martins, Oliveira, Mônica Cristina

“…Combination therapy between paclitaxel (PTX) and doxorubicin (DXR) is applied as the first-line treatment of breast cancer. Co-administration of drugs at…”
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Mechanistic insights into the intracellular release of doxorubicin from pH-sensitive liposomes by dos Reis, Samara Bonesso, de Oliveira Silva, Juliana, Garcia-Fossa, Fernanda, Leite, Elaine Amaral, Malachias, Angelo, Pound-Lana, Gwenaelle, Mosqueira, Vanessa Carla Furtado, Oliveira, Mônica Cristina, de Barros, André Luís Branco, de Jesus, Marcelo Bispo

“…[Display omitted] •The release from pH-sensitive liposomes is more complex than only intraluminal pH decreases.•pH-sensitive liposomes released doxorubicin…”
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Short and Long-Term Effects of the Exposure of Breast Cancer Cell Lines to Different Ratios of Free or Co-Encapsulated Liposomal Paclitaxel and Doxorubicin by Franco, Marina Santiago, Roque, Marjorie Coimbra, Oliveira, Mônica Cristina

“…Associating paclitaxel (PTX) to doxorubicin (DXR) is one of the main chemotherapy strategies for breast cancer (BC) management. Protocols currently available…”
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Technetium-99m-labeled stealth pH-sensitive liposomes: a new strategy to identify infection in experimental model by Carmo, Vildete Aparecida Sousa(Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Produtos Farmacêuticos), Oliveira, Mônica Cristina de(Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Produtos Farmacêuticos), Mota, Luciene das Graças(Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas), Freire, Luís Paulo(Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas), Ferreira, Raphael Ligório Benedito(Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas), Cardoso, Valbert Nascimento(Universidade Federal de Minas Gerais Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas)

“…The diagnosis of inflammatory and infectious processes is an important goal in medicine. The use of radiopharmaceuticals for identification of inflammation and…”
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Investigation of the Antitumor Activity and Toxicity of Tumor-Derived Exosomes Fused with Long-Circulating and pH-Sensitive Liposomes Containing Doxorubicin by Gomes, Eliza Rocha, Souza, Fernanda Rezende, Cassali, Geovanni Dantas, Sabino, Adriano de Paula, Barros, André Luis Branco de, Oliveira, Mônica Cristina

“…Exosome–liposome hybrid nanocarriers containing chemotherapeutic agents have been developed to enhance drug delivery, improve the efficacy of the treatment of…”
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Intestinal toxicity evaluation of long-circulating and pH-sensitive liposomes loaded with cisplatin by Araújo, Raquel Silva, Silveira, Ana Letícia Malheiros, de Sales e Souza, Éricka Lorenna, Freire, Rachel Horta, de Souza, Cristina Maria, Reis, Diego Carlos, Costa, Bruno Rocha Cordeiro, Sugimoto, Michelle Amantéa, Silveira, Josianne Nicácio, dos Santos Martins, Flaviano, Cassali, Geovanni Dantas, Leite, Jacqueline Isaura Alvarez, Sousa, Lirlândia Pires, Ferreira, Adaliene Versiani Matos, Oliveira, Mônica Cristina, Cardoso, Valbert Nascimento

“…Cisplatin (CDDP) is a chemotherapeutic agent widely used in several anticancer protocols for instance head and neck, testicle, ovarian, lung and peritoneal…”
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Liposomal paclitaxel induces apoptosis, cell death, inhibition of migration capacity and antitumoral activity in ovarian cancer by Faria, Raquel Santos, de Lima, Luiza Ianny, Bonadio, Raphael Severino, Longo, João Paulo Figueiró, Roque, Marjorie Coimbra, de Matos Neto, João Nunes, Moya, Sergio Enrique, de Oliveira, Mônica Cristina, Azevedo, Ricardo Bentes

“…The main goal of this study is to evaluate the efficacy of the paclitaxel (PTX) drug formulated with a liposomal nanosystem (L-PTX) in a peritoneal…”
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Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity, and biodistribution evaluation in a mouse model of bone metastasis by Ferreira, Diêgo Dos Santos, Faria, Samilla Dornelas, Lopes, Sávia Caldeira de Araújo, Teixeira, Cláudia Salviano, Malachias, Angelo, Magalhães-Paniago, Rogério, de Souza Filho, José Dias, Oliveira, Bruno Luis de Jesus Pinto, Guimarães, Alexander Ramos, Caravan, Peter, Ferreira, Lucas Antônio Miranda, Alves, Ricardo José, Oliveira, Mônica Cristina

“…Despite recent advances in cancer therapy, the treatment of bone tumors remains a major challenge. A possible underlying hypothesis, limitation, and unmet need…”
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Hybrid Nanosystem Formed by DOX-Loaded Liposomes and Extracellular Vesicles from MDA-MB-231 Is Effective against Breast Cancer Cells with Different Molecular Profiles by Paschoal Barbosa, Luiza Marques, Gomes, Eliza Rocha, Barros, André Luis Branco de, Cassali, Geovanni Dantas, Carvalho, Andréa Teixeira de, Silva, Juliana de Oliveira, Pádua, Ana Luiza, Oliveira, Mônica Cristina

“…Drug delivery selectivity is a challenge for cancer treatment. A hybrid pegylated pH-sensitive liposome-extracellular vesicle isolated from human breast cancer…”
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