Search Results - "Oliveira, Marcia R."
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Design, synthesis and antileishmanial in vitro activity of new series of chalcones-like compounds: A molecular hybridization approach
Published in Bioorganic & medicinal chemistry (15-07-2011)“…The chalcone-like series 1a–1g was efficiently synthesized from Morita–Baylis–Hillman reaction (52–74% yields). Compounds 1a–1g were designed by molecular…”
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Neolignan Licarin A presents effect against Leishmania (Leishmania) major associated with immunomodulation in vitro
Published in Experimental parasitology (01-10-2013)“…•Licarin A inhibits the proliferation of Leishmania (L.) major promastigotesin vitro.•This neolignan induces DNA fragmentation on L. (L.) major…”
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Morphological and physiological changes in Leishmania promastigotes induced by yangambin, a lignan obtained from Ocotea duckei
Published in Experimental parasitology (2011)“…We have previously demonstrated that yangambin, a lignan obtained from Ocotea duckei Vattimo (Lauraceae), shows antileishmanial activity against promastigote…”
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Synthesis, evaluation against Leishmania amazonensis and cytotoxicity assays in macrophages of sixteen new congeners Morita–Baylis–Hillman adducts
Published in European journal of medicinal chemistry (01-09-2011)“…We report the design, synthesis, in vitro evaluation against Leishmania amazonensis (IC 50), cytotoxicity assays in macrophages (CC 50), and selectivity index…”
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Efficient synthesis of 16 aromatic Morita–Baylis–Hillman adducts: Biological evaluation on Leishmania amazonensis and Leishmania chagasi
Published in Bioorganic chemistry (01-12-2010)“…We described “one-pot” Morita-Baylis-Hillman reactions to produced 16 aromatic compounds (81-100%), its bio-evaluations on L. Amazonensis and L. chagasi and a…”
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Yangambin Cytotoxicity: A Pharmacologically Active Lignan Obtained from Ocotea duckei Vattimo (Lauraceae)
Published in Zeitschrift für Naturforschung C. A journal of biosciences (01-09-2008)“…The in vitro cytotoxic potential of yangambin was evaluated. Yangambin is a pharmacologically active furofuran lignan obtained from the leaves of Ocotea…”
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Crude Ethanolic Extract, Lignoid Fraction and Yangambin from Ocotea duckei (Lauraceae) Show Antileishmanial Activity
Published in Zeitschrift für Naturforschung C. A journal of biosciences (01-05-2007)“…Crude ethanolic extract, lignoid fraction and the purified compound yangambin were obtained from Ocotea duckei (Lauraceae) and their antileishmanial activity…”
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Antileishmanial activity of new thiophene–indole hybrids: Design, synthesis, biological and cytotoxic evaluation, and chemometric studies
Published in Bioorganic & medicinal chemistry (15-09-2016)“…[Display omitted] •32 hybrid thiophene–indolyl derivatives were synthesized and characterized.•Various compounds showed good antileishmanial activity (IC50…”
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Evaluation of wound healing effect of alginate films containing Aloe vera (Aloe barbadensis Miller) gel
Published in Journal of biomaterials applications (01-04-2018)“…A new alginate dressing with Aloe vera gel was developed and used to study its cutaneous healing effect in vivo by surgical wounds in Wistar rats. The…”
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Kinetic resolution of leishmanicidal meta and para (±)-2-[Hydroxy(nitrophenyl)methyl]acrylonitrile catalyzed by CALB: In vitro evaluations of separated meta (R), (S) and (R/S) adducts
Published in Journal of molecular catalysis. B, Enzymatic (01-10-2014)“…•MBHA racemates employing the lipase B from Candida antarctica.•MTPA Mosher's procedure was used to determine the absolute configurations.•Investigation of the…”
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Improved synthesis of seven aromatic Baylis–Hillman adducts (BHA): Evaluation against Artemia salina Leach. and Leishmania chagasi
Published in European journal of medicinal chemistry (01-04-2009)“…We described a very efficient procedure to prepare seven aromatic compounds ( 1– 7), a new class of antileishmanial substances, through Baylis–Hillman reaction…”
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Antibacterial and antiparasitic effects of Bothropoides lutzi venom
Published in Natural product communications (01-01-2012)“…The therapeutic potential of toxins has aroused great interest in the scientific community. Microbial resistance is a serious current public health problem, in…”
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Anti-mitotic activity towards sea urchin eggs of dichloromethane fraction obtained from Allamanda schottii Pohl (Apocynaceae)
Published in Revista brasileira de farmacognosia (01-06-2009)“…Allamanda (Apocynaceae) is a genus of climbing shrubs known for producing compounds with a range of biological activities. Previous works have shown the…”
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Attributable mortality due to nosocomial sepsis in Brazilian hospitals: a case–control study
Published in Annals of intensive care (26-04-2023)“…Background Nosocomial sepsis is a major healthcare issue, but there are few data on estimates of its attributable mortality. We aimed to estimate attributable…”
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Dielectric properties of papaya seeds from 75 kHz to 5 MHz
Published in International Agrophysics (01-01-2019)Get full text
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