Abstract 428: Positive correlation of beta1 integrin expression and prognosis in clinically localized prostate cancer
Introduction and objective: Integrins are transmembrane glycoprotein receptors that regulate cell-matrix interactions, functioning as sensors of the environment. They also act as cell adhesion molecules, being responsible for the maintenance of the epithelial phenotype. Some studies have reported co...
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| Published in: | Cancer research (Chicago, Ill.) Vol. 71; no. 8_Supplement; p. 428 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
15-04-2011
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| Online Access: | Get full text |
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| Summary: | Introduction and objective: Integrins are transmembrane glycoprotein receptors that regulate cell-matrix interactions, functioning as sensors of the environment. They also act as cell adhesion molecules, being responsible for the maintenance of the epithelial phenotype. Some studies have reported correlation between alterations of integrins expression and carcinogenesis, specially β1 integrin, but their role in prostate cancer is unclear. Our aim is to study the expression of β1 integrin and evaluate its association with recurrence of prostate cancer after surgical treatment
Methods: For this case-control study, we selected 111 patients with localized tumor submitted to radical prostatectomy by the same surgeon. 60 of these patients have not presented recurrence after a median follow-up of 123 months. Recurrence was defined as a PSA level above 0.4ng/ml. Integrin expression was evaluated by immunohistochemistry in a Tissue Microarray containing two samples from each tumor. We employed a semiquantitative analysis and considered a case as positive when the expression was strong and diffusely present. We correlated expression with recurrence employing the χ2 test and p<0.05 was considered significant.
Results: Positive expression of β1 integrin was found in 79 out of 100 evaluated cases, ten cases were lost in the tissue microarray. Correlating expression with recurrence we found in the univariate analysis that negative expression of β1 integrin was statistically associated with recurrence (p=0,042) and time to recurrence after radical prostatectomy, when expression of β1 is negative, the odds of recurrence was two times higher than that observed in positive cases (p=0.026 – IC 95% [1.09; 3.83]. In multivariate analysis, including PSA and Gleason, β1 integrin remained independently associated with recurrence p=0.01.
Conclusions: In the present study we have shown that a down regulation of β1integrin expression was significantly correlated with recurrence after radical prostatectomy for localized prostate cancer, making this integrin a potential candidate as a marker of prognosis. Larger series will be evaluated in order to confirm our initial findings
Figure Kaplan Meier curve for recurrence-free survival according to β1expression in 111primaryPCa submitted to RP
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 428. doi:10.1158/1538-7445.AM2011-428 |
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| ISSN: | 0008-5472 1538-7445 |
| DOI: | 10.1158/1538-7445.AM2011-428 |