Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi

Canine visceral leishmaniasis (CVL) is a zoonotic disease with different clinical manifestations. Parasitism often occurs in bone marrow, but changes have been observed in peripheral blood and serum biochemical parameters. The aim of this study was to evaluate the hematological and biochemical param...

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Published in:	Revista da Sociedade Brasileira de Medicina Tropical Vol. 45; no. 1; pp. 24 - 29
Main Authors:	Freitas, José Cláudio Carneiro de, Nunes-Pinheiro, Diana Célia Sousa, Lopes Neto, Belarmino Eugênio, Santos, Glauco Jonas Lemos, Abreu, Cyntia Rafaelle Amaral de, Braga, Roberta Rocha, Campos, Rafael de Morais, Oliveira, Ligene Fernandes de
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Medicina Tropical 01-02-2012 Sociedade Brasileira de Medicina Tropical - SBMT Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects:	Anemia Animals Biomarcadores Biomarkers Bone marrow Cachexia - veterinary Clinical trials Cães Dog Diseases - blood Dog Diseases - diagnosis Dogs Fluorescent Antibody Technique Hematology Hiperglobulinemia Infections Keratoconjunctivitis - veterinary Laboratories Leishmania donovani - immunology Leishmania donovani - isolation & purification Leishmaniasis, Visceral - blood Leishmaniasis, Visceral - complications Leishmaniasis, Visceral - diagnosis Leishmaniasis, Visceral - veterinary Leishmaniose visceral canina Lymphatic Diseases - veterinary Male Parasitism TROPICAL MEDICINE Uremia Vector-borne diseases Zoonoses Hyperglobulinemia Anemia Hiperglobulinemia Dogs Leishmaniose visceral canina Biomarkers Canine visceral leishmanisis Biomarcadores Uremia Cães
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Summary:	Canine visceral leishmaniasis (CVL) is a zoonotic disease with different clinical manifestations. Parasitism often occurs in bone marrow, but changes have been observed in peripheral blood and serum biochemical parameters. The aim of this study was to evaluate the hematological and biochemical parameters in dogs naturally infected by Leishmania chagasi. Eighty-five adult dogs of both sexes and various weights and ages from the Zoonosis Control Center of Fortaleza (CCZ) were used, selected by immunofluorescence assay (IFA) and considered positive with IFA titers greater than 1:40 and by visualizing amastigotes of Leishmania chagasi in smears obtained by bone marrow aspiration. The dogs (n = 85) were grouped according to clinical signs: negative (CN = 7), subclinical (CS = 10), and clinical (CC = 68). Blood samples were collected for determination of hematological and biochemical serum values. The experimental protocol was approved by the CEUA/UECE. The most frequent clinical signs were cachexia (77.9%), keratitis (61.8%), and lymphadenopathy (55.9%), and 86.8% of the animals showed more than one clinical sign characteristic of CVL. In CC were observed reductions in red blood cells (63%), hematocrit (72%), and hemoglobin (62%), as well as leukocytosis (33%), neutropenia (28%), thrombocytopenia (50%), uremia (45%), hyperproteinemia (53%, p<0.05), hypergammaglobulinemia (62%, p<0.01), and hypoalbuminemia (58%). Animals with the clinical form of the disease demonstrate hematological and biochemical changes consistent with anemia, uremia, hyperproteinemia, and hyperglobulinemia, which present themselves as strong clinical markers of visceral leishmaniasis associated with the signs previously reported.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0037-8682 1678-9849 1678-9849 0037-8682
DOI:	10.1590/S0037-86822012000100006