Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma

non-edited manuscript The first publication that associated Human Papillomavirus (HPV) infection and esophageal cancer was published in 1982. However, data are still contradictory and require further investigation. The aim of this study was to identify high risk HPV DNA in esophageal tissue of patie...

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Published in:	Histology and histopathology Vol. 33; no. 4; pp. 357 - 363
Main Authors:	Costa, Allini Mafra da, Fregnani, José Humberto Tavares Guerreiro, Pastrez, Paula Roberta Aguiar, Mariano, Vânia Sammartino, Neto, Cristovam Scapulatempo, Guimarães, Denise Peixoto, Oliveira, Kelly Menezio Giordina de, Neto, Said Abdala Zemi, Nunes, Emily Montosa, Longatto, Adhemar
Format:	Journal Article
Language:	English
Published:	Spain Universidad de Murcia 01-04-2018
Subjects:	Adult Aged Brazil - epidemiology Cancer Epidemiology Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - virology Case-Control Studies Ciências Médicas DNA, Viral - genetics Esophageal cancer Esophageal Neoplasms Esophageal Neoplasms - epidemiology Esophageal Neoplasms - virology Esophageal Squamous Cell Carcinoma Esophagus - virology Female Human Papillomavirus Humans Male Medicina Básica Middle Aged Papillomaviridae Papillomavirus Infections - complications Papillomavirus Infections - epidemiology Prevalence Risk Factors Science & Technology Brazil
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Summary:	non-edited manuscript The first publication that associated Human Papillomavirus (HPV) infection and esophageal cancer was published in 1982. However, data are still contradictory and require further investigation. The aim of this study was to identify high risk HPV DNA in esophageal tissue of patients with and without esophageal squamous cell carcinoma (ESCC) and correlate HPV presence with classical risk factors. METHODS: Invited patients signed the informed consent form, and interviews were conducted in order to obtain information about sociodemographic and lifestyle behavior. During endoscopy, esophageal biopsies were collected from case and controls. Multiplex polymerase chain reaction genotyping was conducted on endoscopic biopsies to identify HPV types and HPV-16 was further evaluated by specific PCR real time. RESULTS: Among 87 cases, 12 (13.8%) had tumors harboring high risk HPV DNA and among 87 controls, 12 (13.8%) had high risk HPV DNA (OR:1.025 [CI:0.405:2.592]). Variables regarding consumption of alcohol and use of tobacco continued to characterize risk factors even after adjustments by presence or absence of high risk HPV. CONCLUSION: HPV was demonstrated to be frequently and similarly associated to normal and malignant esophageal tissues, but not as an independent risk factor to esophageal cancer. IMPACT: To contribute to the Brazilian population data on this subject, which is still contradictory. CNPq Universal for providing supplies to the largest study, of which this study is a part of, entitled “The role of human papillomavirus (HPV) as the etiologic agent of esophageal cancer. A cross-sectional study, case-control and longitudinal at Barretos Cancer Hospital”; (Grant number 482666/2012-9 to ALF); INCT HPV [Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [Grant number 08/57889-1 to LLV]; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant number 573799/2008-3 to LLV)]
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1699-5848
DOI:	10.14670/HH-11-929