Predictors of conversion from major depressive disorder to bipolar disorder

•-Risk factors for a change from MDD to BD included female and younger age.•-Other risk factors for BD are low schooling level and lifetime use of illicit substances.•-We found that the diagnostic conversion rate from MDD to BD was 12.4%. The present study has two main aims: (1) To assess whether ch...

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Bibliographic Details
Published in:	Psychiatry research Vol. 297; p. 113740
Main Authors:	Oliveira, Joseigla Pinto de, Jansen, Karen, Cardoso, Taiane de Azevedo, Mondin, Thaíse Campos, Souza, Luciano Dias de Mattos, Silva, Ricardo Azevedo da, Pedrotti Moreira, Fernanda
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-03-2021
Subjects:	bipolar disorder Childhood trauma conversion major depressive disorder bipolar disorder major depressive disorder Childhood trauma conversion
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Summary:	•-Risk factors for a change from MDD to BD included female and younger age.•-Other risk factors for BD are low schooling level and lifetime use of illicit substances.•-We found that the diagnostic conversion rate from MDD to BD was 12.4%. The present study has two main aims: (1) To assess whether childhood trauma helps to differentiate Major Depressive Disorder (MDD) from Bipolar Disorder (BD) in a cross-sectional design; and (2) Describe the rate of conversion from MDD to BD, as well as the clinical and demographic predictors of conversion from MDD to BD in a prospective cohort design. We conducted a prospective cohort study in two phases, in the city of Pelotas, RS, Brazil. In the first phase, 565 subjects diagnosed with MDD, and 127 with BD according to the Mini International Neuropsychiatric Interview were included. In the second phase, only individuals with MDD were reevaluated for potential conversion to BD. The rate of conversion from MDD to BD in 3 years was 12.4%. Predictors of conversion from MDD to BD included lower educational level, use of illicit substances, younger age of the first depressive episode, and family history of BD. Childhood trauma was not a significant risk factor for conversion to BD in our prospective study. Our findings can contribute to the prevention and identification of conversion from MDD to BD, as well as to the establishment of more targeted therapeutic interventions, improving the prognosis of these individuals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0165-1781 1872-7123
DOI:	10.1016/j.psychres.2021.113740