Search Results - "Oliveira, Helena C.F"

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities by Ronchi, Juliana A., Figueira, Tiago R., Ravagnani, Felipe G., Oliveira, Helena C.F., Vercesi, Anibal E., Castilho, Roger F.

“…NADPH is the reducing agent for mitochondrial H2O2 detoxification systems. Nicotinamide nucleotide transhydrogenase (NNT), an integral protein located in the…”
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Mitochondrial bioenergetics and redox dysfunctions in hypercholesterolemia and atherosclerosis by Oliveira, Helena C.F., Vercesi, Anibal E.

“…In the first part of this review, we summarize basic mitochondrial bioenergetics concepts showing that mitochondria are critical regulators of cell life and…”
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Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice by Navarro, Claudia D.C., Figueira, Tiago R., Francisco, Annelise, Dal'Bó, Genoefa A., Ronchi, Juliana A., Rovani, Juliana C., Escanhoela, Cecilia A.F., Oliveira, Helena C.F., Castilho, Roger F., Vercesi, Anibal E.

“…The mechanisms by which a high fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) appear to involve liver mitochondrial dysfunctions and redox…”
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Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases by Oliveira, Helena C F, Raposo, Helena F

“…In this chapter, we present the major advances in CETP research since the detection, isolation, and characterization of its activity in the plasma of humans…”
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Dichloroacetate reactivates pyruvate-supported peroxide removal by liver mitochondria and prevents NAFLD aggravation in NAD(P)+ transhydrogenase-null mice consuming a high-fat diet by Navarro, Claudia D.C., Francisco, Annelise, Figueira, Tiago R., Ronchi, Juliana A., Oliveira, Helena C.F., Vercesi, Anibal E., Castilho, Roger F.

“…The mechanisms by which a high-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) appear to involve liver mitochondrial dysfunction and redox…”
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In vivo chronic exposure to inorganic mercury worsens hypercholesterolemia, oxidative stress and atherosclerosis in the LDL receptor knockout mice by Queiroz, Maiara I.C., Lazaro, Carolina M., dos Santos, Lohanna M.B., Rentz, Thiago, Virgilio-da-Silva, João V., Moraes-Vieira, Pedro M.M., Cunha, Francisco A.S., Santos, Josué C.C., Vercesi, Anibal E., Leite, Ana Catarina R., Oliveira, Helena C.F.

“…Heavy metal exposure leads to multiple system dysfunctions. The mechanisms are likely multifactorial and involve inflammation and oxidative stress. The aim of…”
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Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death by Nardelli, Tarlliza R., Wanschel, Amarylis C. B. A., Raposo, Helena F., Paiva, Adriene A., Oliveira, Helena C. F.

“…Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic…”
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Chronic use of pravastatin reduces insulin exocytosis and increases β-cell death in hypercholesterolemic mice by Lorza-Gil, Estela, Salerno, Alessandro G, Wanschel, Amarylis C.B.A, Vettorazzi, Jean F, Ferreira, Mônica S, Rentz, Thiago, Catharino, Rodrigo R, Oliveira, Helena C.F

“…Highlights • Hypercholesterolemic mice have reduced insulin secretion. • We hypothesized that pravastatin treatment improves insulin secretion. • Pravastatin…”
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A systematic review and meta-analyses on the effects of atorvastatin on blood pressure and heart rate by Costa, Gabriel S, Julião-Silva, Letícia S, Belo, Vinícius S, de Oliveira, Helena C F, Chaves, Valéria E

“…Abstract Aims Considering the inconsistencies in the literature on the atorvastatin effect on blood pressure (BP), we performed these meta-analyses. Methods…”
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Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis by Oliveira, Helena C. F., Catharino, Rodrigo R., Ferreira, Mônica S., Kiihl, Samara F., Paim, Bruno A., Dorighello, Gabriel G., Vercesi, Anibal E.

“…Atherosclerosis has been associated with mitochondria dysfunction and damage. Our group demonstrated previously that hypercholesterolemic mice present…”
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Distinct hepatic lipid profile of hypertriglyceridemic mice determined by easy ambient sonic-spray ionization mass spectrometry by Alberici, Luciane C., Oliveira, Helena C. F., Catharino, Rodrigo R., Vercesi, Anibal E., Eberlin, Marcos N., Alberici, Rosana M.

“…Easy ambient sonic-spray ionization mass spectrometry (EASI-MS) was used to interrogate the hepatic lipid profiles of hypertriglyceridemic and control…”
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Reduction of endoplasmic reticulum stress—A novel mechanism of action of statins in the protection against atherosclerosis by Breder, Ikaro, Coope, Andressa, Arruda, Ana Paula, Razolli, Daniela, Milanski, Marciane, Dorighello, Gabriel de Gabriel, de Oliveira, Helena C.F, Velloso, Lício A

“…Abstract Fatty-acid-induced endoplasmic reticulum stress has been recently described as a novel mechanism involved in the genesis of atherosclerosis. Here we…”
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CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion by Harada, Lila M, Amigo, Ludwig, Cazita, Patrícia M, Salerno, Alessandro G, Rigotti, Attilio A, Quintão, Eder C.R, Oliveira, Helena C.F

“…Abstract The aim of this work was to study how CETP expression affects whole body cholesterol homeostasis. Thus, tissue uptake and plasma removal rates of…”
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Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice by Cazita, Patrícia M, Berti, Jairo A, Aoki, Carolina, Gidlund, Magnus, Harada, Lila M, Nunes, Valéria S, Quintão, Eder C R, Oliveira, Helena C F

“…Reduced estrogen levels result in loss of protection from coronary heart disease in postmenopausal women. Enhanced and diminished atherosclerosis have been…”
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Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition by Vercesi, Anibal E., Castilho, Roger F., Kowaltowski, Alicia J., de Oliveira, Helena C.F., de Souza-Pinto, Nadja C., Figueira, Tiago R., Busanello, Estela N.B.

“…Mitochondria possess a Ca2+ transport system composed of separate Ca2+ influx and efflux pathways. Intramitochondrial Ca2+ concentrations regulate oxidative…”
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Mitochondrial Adaptive Responses to Hypertriglyceridemia and Bioactive Lipids by Alberici, Luciane C, Oliveira, Helena C F

“…Altered plasma triglyceride metabolism and changes in dietary fatty acid types and levels are major contributors to the development of metabolic and…”
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Chronic treatment with bark infusion from Croton cajucara lowers plasma triglyceride levels in genetic hyperlipidemic mice by Bighetti, Eliete J B, Souza-Brito, Alba R M, de Faria, Eliana C, Oliveira, Helena C F

“…Aqueous infusion and preparations containing dehydrocrotonin (DHC) and essential oil from Croton cajucara bark were tested for plasma lipid-lowering effects in…”
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Cholesteryl Ester Transfer Protein Activity Enhances Plasma Cholesteryl Ester Formation: Studies in CETP Transgenic Mice and Human Genetic CETP Deficiency by Oliveira, Helena C.F, Milne, Ross, Marcovina, Santica M, Inazu, Akihiro, Mabuchi, Hiroshi, Tall, Alan R

“…The plasma cholesteryl ester transfer protein (CETP) promotes the removal of HDL cholesteryl esters and is thought to stimulate reverse cholesterol transport…”
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The fatty acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas by Agostini, Michelle, Almeida, Luciana Y, Bastos, Débora C, Ortega, Rose M, Moreira, Fernanda S, Seguin, Fabiana, Zecchin, Karina G, Raposo, Helena F, Oliveira, Helena C F, Amoêdo, Nivea D, Salo, Tuula, Coletta, Ricardo D, Graner, Edgard

“…Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous synthesis of fatty acids. It is downregulated in most normal cells, except…”
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Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity by Raposo, Helena F., Forsythe, Patricia, Chausse, Bruno, Castelli, Júlia Z., Moraes-Vieira, Pedro M., Nunes, Valéria S., Oliveira, Helena C.F.

“…The systemic function of CETP has been well characterized. CETP plasma activity reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here,…”
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