B and T cell subsets in elderly with frailty syndrome
Background: Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability to stress secondary to a decline in homeostasis caused by dysregulation. Objectiv...
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| Published in: | Translational medicine of aging Vol. 7; pp. 118 - 127 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd
2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Background: Aging is related to changes in functional reserve that progressively lead to increased morbidity and mortality. Frailty syndrome, a common entity in older adults, is characterized by increased vulnerability to stress secondary to a decline in homeostasis caused by dysregulation. Objective: The study aimed to evaluate the immunocompetence of elderly individuals with frailty syndrome. Methods: A cross-sectional and translational study was carried with sixty-nine older adults with frailty syndrome (patients) and 42 healthy older adults (controls) were included. Results: Low naive TCD4+ cells (P = 0.03) in patients with Frailty syndrome compared to controls. Low levels of total T cells (P = 0.01), TCD4+ (P = 0.005), and TCD4+/TCD8+ ratio (P = 0.04), memory T cells (P = 0.02), memory TCD4+ (P = 0.001), memory T CD8+ (P < 0.0001), and high levels of naïve/memory T cells ratio (p = 0.008) in Frailty syndrome patients with age ≥70 years. Conclusion: Older adults with frailty syndrome have alterations in the cellular immune response, and these findings may be associated with increased morbidity and mortality in these patients. |
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| ISSN: | 2468-5011 2468-5011 |
| DOI: | 10.1016/j.tma.2023.10.001 |