Search Results - "Oliveira, Bruno L"

Contemporary approaches to site-selective protein modification by Hoyt, Emily A., Cal, Pedro M. S. D., Oliveira, Bruno L., Bernardes, Gonçalo J. L.

“…Proteins constitute the majority of nature’s worker biomolecules. Designed for specific functions, complex tertiary structures make proteins ideal candidates…”
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Chemo- and Regioselective Lysine Modification on Native Proteins by Matos, Maria J, Oliveira, Bruno L, Martínez-Sáez, Nuria, Guerreiro, Ana, Cal, Pedro M. S. D, Bertoldo, Jean, Maneiro, María, Perkins, Elizabeth, Howard, Julie, Deery, Michael J, Chalker, Justin M, Corzana, Francisco, Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L

“…Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods,…”
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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents by Bernardim, Barbara, Cal, Pedro M.S.D., Matos, Maria J., Oliveira, Bruno L., Martínez-Sáez, Nuria, Albuquerque, Inês S., Perkins, Elizabeth, Corzana, Francisco, Burtoloso, Antonio C.B., Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L.

“…Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conjugates despite the known instability of the resulting…”
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A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging by Stenton, Benjamin J, Oliveira, Bruno L, Matos, Maria J, Sinatra, Laura, Bernardes, Gonçalo J L

“…We describe the development of a bifunctional linker that simultaneously allows site-specific protein modification and palladium-mediated bioorthogonal…”
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A fluorogenic probe for cell surface phosphatidylserine using an intramolecular indicator displacement sensing mechanism by Zwicker, Vincent E., Oliveira, Bruno, Yeo, Jia Hao, Fraser, Stuart T., Bernardes, Gonçalo, New, Elizabeth J., Jolliffe, Katrina A.

“…© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The detection of externalized phosphatidylserine (PS) on the cell surface is commonly used to distinguish…”
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Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions by Zawada, Zbigniew, Guo, Zijian, Oliveira, Bruno L, Navo, Claudio D, Li, He, Cal, Pedro M. S. D, Corzana, Francisco, Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L

“…Strained alkenes and alkynes are the predominant dienophiles used in inverse electron demand Diels–Alder (IEDDA) reactions. However, their instability,…”
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Peptide-based fibrin-targeting probes for thrombus imaging by Oliveira, Bruno L, Caravan, Peter

“…The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific…”
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Re(I) and Tc(I) Complexes for Targeting Nitric Oxide Synthase: Influence of the Chelator in the Affinity for the Enzyme by Oliveira, Bruno L., Morais, Maurício, Mendes, Filipa, Moreira, Irina S., Cordeiro, Carlos, Fernandes, Pedro A., Ramos, Maria J., Alberto, Roger, Santos, Isabel, Correia, João D. G.

“…Aiming to design 99mTc complexes for probing nitric oxide synthase (NOS) by SPECT, we synthesized conjugates (L4–L6) comprising a NOS‐recognizing moiety…”
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Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions by Latocheski, Eloah, Dal Forno, Gean M, Ferreira, Thuany M, Oliveira, Bruno L, Bernardes, Gonçalo J L, Domingos, Josiel B

“…Cleavage of C-O and C-N bonds mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged molecules, such as proteins…”
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Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N -Propargyl Handles for Drug-Activation by Oliveira, Bruno L, Stenton, Benjamin J, Unnikrishnan, V B, de Almeida, Cátia Rebelo, Conde, João, Negrão, Magda, Schneider, Felipe S S, Cordeiro, Carlos, Ferreira, Miguel Godinho, Caramori, Giovanni F, Domingos, Josiel B, Fior, Rita, Bernardes, Gonçalo J L

“…The ability to create ways to control drug activation at specific tissues while sparing healthy tissues remains a major challenge. The administration of…”
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Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells by Jiménez‐Moreno, Ester, Guo, Zijian, Oliveira, Bruno L., Albuquerque, Inês S., Kitowski, Annabel, Guerreiro, Ana, Boutureira, Omar, Rodrigues, Tiago, Jiménez‐Osés, Gonzalo, Bernardes, Gonçalo J. L.

“…The cleavage of a protecting group from a protein or drug under bioorthogonal conditions enables accurate spatiotemporal control over protein or drug activity…”
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A new bisphosphonate-containing 99mTc(I) tricarbonyl complex potentially useful as bone-seeking agent: synthesis and biological evaluation by Palma, Elisa, Oliveira, Bruno L., Correia, João D. G., Gano, Lurdes, Maria, Leonor, Santos, Isabel C., Santos, Isabel

“…Aiming to develop new bone-seeking radiotracers based on the organometallic core fac-[99mTc(CO)3]+ with improved radiochemical and biological properties, we…”
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Development of a self-immolative linker for tetrazine-triggered release of alcohols in cells by Davies, Sarah, Oliveira, Bruno L, Bernardes, Gonçalo J L

“…Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involve bond cleavage to release a molecule of interest. The…”
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Radical‐Mediated Thiol‐Ene Strategy: Photoactivation of Thiol‐Containing Drugs in Cancer Cells by Sun, Shuang, Oliveira, Bruno L., Jiménez‐Osés, Gonzalo, Bernardes, Gonçalo J. L.

“…Photoactivated drugs provide an opportunity to improve efficacy alongside reducing side‐effects in the treatment of severe diseases such as cancer. Described…”
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Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions by Dal Forno, Gean M., Latocheski, Eloah, Beatriz Machado, Ana, Becher, Julie, Dunsmore, Lavinia, St. John, Albert L., Oliveira, Bruno L., Navo, Claudio D., Jiménez-Osés, Gonzalo, Fior, Rita, Domingos, Josiel B., Bernardes, Gonçalo J. L.

“…The ability to control the activation of prodrugs by transition metals has been shown to have great potential for controlled drug release in cancer cells…”
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In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry by Ferreira, Vera F. C, Oliveira, Bruno L, D’Onofrio, Alice, Farinha, Carlos M, Gano, Lurdes, Paulo, António, Bernardes, Gonçalo J. L, Mendes, Filipa

“…Pretargeted imaging has emerged as an effective multistep strategy aiming to improve imaging contrast and reduce patient radiation exposure through decoupling…”
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Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats by Blasi, Francesco, Oliveira, Bruno L, Rietz, Tyson A, Rotile, Nicholas J, Naha, Pratap C, Cormode, David P, Izquierdo-Garcia, David, Catana, Ciprian, Caravan, Peter

“…Thrombosis is a leading cause of morbidity and mortality worldwide. Current diagnostic strategies rely on imaging modalities that are specific for distinct…”
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Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells by Alcock, Lisa J, Oliveira, Bruno L, Deery, Michael J, Pukala, Tara L, Perkins, Michael V, Bernardes, Gonçalo J. L, Chalker, Justin M

“…Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is…”
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High sensitivity HPLC method for determination of the allysine concentration in tissue by use of a naphthol derivative by Waghorn, Philip A., Oliveira, Bruno L., Jones, Chloe M., Tager, Andrew M., Caravan, Peter

“…•Improved method to quantify the allysine concentration in tissue samples using HPLC.•Assay sensitive to 0.02pmol of allysine from milligram quantities of…”
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Tetrazine‐Triggered Release of Carboxylic‐Acid‐Containing Molecules for Activation of an Anti‐inflammatory Drug by Davies, Sarah, Qiao, Luxi, Oliveira, Bruno L., Navo, Claudio D., Jiménez‐Osés, Gonzalo, Bernardes, Gonçalo J. L.

“…In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug…”
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