Search Results - "Oliveira, Ana Flávia C. S."
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Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds
Published in PloS one (26-09-2019)“…The West Nile Virus (WNV) NS2B-NS3 protease is an attractive target for the development of therapeutics against this arboviral pathogen. In the present…”
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Journal Article -
2
Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease
Published in European journal of medicinal chemistry (10-04-2018)“…A simple and efficient Knoevenagel procedure for the synthesis of 2-arylidene indan-1,3-diones is herein reported. These compounds were prepared via…”
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Journal Article -
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NS3 and NS5 Proteins: Important Targets for Anti-Dengue Drug Design
Published in Journal of the Brazilian Chemical Society (01-10-2014)“…Dengue is a neglected disease, one that is responsible for 22,000 deaths each year in areas where it is endemic. Despite the tremendous efforts invested in…”
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Journal Article