Search Results - "Olivares Illana, Vanesa"
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Retinoblastoma: from discovery to clinical management
Published in The FEBS journal (01-08-2022)“…The retinoblastoma gene (RB1) was the first tumour suppressor cloned; the role of its protein product (RB) as the principal driver of the G1 checkpoint in cell…”
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MDM2 regulates RB levels during genotoxic stress
Published in EMBO reports (07-01-2021)“…The retinoblastoma tumour suppressor protein (RB) regulates a number of diverse cellular functions including differentiation, angiogenesis, chromatin…”
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Characterization of wild‐type and mutant p53 protein by Raman spectroscopy and multivariate methods
Published in Journal of Raman spectroscopy (01-10-2019)“…To improve the early and reliable detection of cancer novel methods for the identification of associated biomarkers can suppose a big advantage over most of…”
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p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction
Published in Protein science (01-05-2018)“…HDM2 and HDMX are two homologs essential for controlling p53 tumor suppressor activity under normal conditions. Both proteins bind different sites on the p53…”
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The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage
Published in Cancer cell (17-01-2012)“…The ATM kinase and p53 are key tumor suppressor factors that control the genotoxic stress response pathway. The ATM substrate Mdm2 controls p53 activity by…”
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A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease
Published in Proteins, structure, function, and bioinformatics (01-07-2017)“…ABSTRACT Triosephosphate isomerase (TIM) is a ubiquitous enzyme, which appeared early in evolution. TIM is responsible for obtaining net ATP from glycolysis…”
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Analysis of the p53 pathway in peripheral blood of retinoblastoma patients; potential biomarkers
Published in PloS one (05-06-2020)“…Loss of retinoblastoma (RB) function in the cone cells during retina development is necessary but not sufficient for retinoblastoma development. It has been…”
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Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms
Published in Biomolecules (Basel, Switzerland) (30-12-2020)“…The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of interactions with multiple partners and functions. Intrinsically disordered…”
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Structural basis for the regulation mechanism of the tyrosine kinase CapB from Staphylococcus aureus
Published in PLoS biology (01-06-2008)“…Bacteria were thought to be devoid of tyrosine-phosphorylating enzymes. However, several tyrosine kinases without similarity to their eukaryotic counterparts…”
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Comparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureus
Published in PloS one (11-10-2013)“…A particular class of tyrosine-kinases sharing no structural similarity with eukaryotic tyrosine-kinases has been evidenced in a large array of bacterial…”
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Molecular Characterization of Inulosucrase from Leuconostoc citreum: a Fructosyltransferase within a Glucosyltransferase
Published in Journal of Bacteriology (01-06-2003)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Perturbation of the dimer interface of triosephosphate isomerase and its effect on Trypanosoma cruzi
Published in PLoS neglected tropical diseases (31-10-2007)“…Chagas disease affects around 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease. The drugs…”
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Multi, inter y transdisciplina, aportes para una mejor interpretación de sus significados
Published in Nova scientia (01-11-2022)“…Los términos multidisciplina, interdisciplina y transdisciplina son más usados que definidos, lo que genera que sean términos confusos; por lo que requieren…”
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The p53 mRNA: an integral part of the cellular stress response
Published in Nucleic acids research (23-04-2019)“…Abstract A large number of signalling pathways converge on p53 to induce different cellular stress responses that aim to promote cell cycle arrest and repair…”
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HDMX Folds the Nascent p53 mRNA following Activation by the ATM Kinase
Published in Molecular cell (08-05-2014)“…Regulated protein synthesis via changes in mRNA structures forms an important part of how prokaryotic cells adapt protein expression in response to changes in…”
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Expression and purification of the recombinant full-length retinoblastoma protein and characterisation of its interaction with the oncoprotein HDM2
Published in Protein expression and purification (01-10-2019)“…Retinoblastoma (Rb) was the first tumour suppressor factor described, and it is dysfunctional in several types of cancers. Structurally, Rb is a very large,…”
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Actin protein inside DMPC GUVs and its mechanical response to AC electric fields
Published in Biochimica et biophysica acta. Biomembranes (01-05-2022)“…Cells are dynamic systems with complex mechanical properties, regulated by the presence of different species of proteins capable to assemble (and disassemble)…”
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Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB
Published in Genes & cancer (01-09-2016)“…The orchestrated crosstalk between the retinoblastoma (RB) and p53 pathways contributes to preserving proper homeostasis within the cell. The deregulation of…”
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A single synonymous mutation determines the phosphorylation and stability of the nascent protein
Published in Journal of molecular cell biology (01-03-2019)“…p53 is an intrinsically disordered protein with a large number of post-translational modifications and interacting partners. The hierarchical order and…”
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Understanding a Core Pilin of the Type IVa Pili of Acidithiobacillus thiooxidans , PilV
Published in Journal of microbiology and biotechnology (28-03-2024)“…Pilins are protein subunits of pili. The pilins of type IV pili (T4P) in pathogenic bacteria are well characterized, but anything is known about the T4P…”
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