Search Results - "Oliva, Glaucius"

Molecular docking and structure-based drug design strategies by Ferreira, Leonardo G, Dos Santos, Ricardo N, Oliva, Glaucius, Andricopulo, Adriano D

“…Pharmaceutical research has successfully incorporated a wealth of molecular modeling methods, within a variety of drug discovery programs, to study complex…”
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Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease by Noske, Gabriela Dias, de Souza Silva, Ellen, de Godoy, Mariana Ortiz, Dolci, Isabela, Fernandes, Rafaela Sachetto, Guido, Rafael Victório Carvalho, Sjö, Peter, Oliva, Glaucius, Godoy, Andre Schutzer

“…SARS-CoV-2 is the causative agent of COVID-19. The main viral protease (Mpro) is an attractive target for antivirals. The clinically approved drug nirmatrelvir…”
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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase by Godoy, Andre S., Lima, Gustavo M. A., Oliveira, Ketllyn I. Z., Torres, Naiara U., Maluf, Fernando V., Guido, Rafael V. C., Oliva, Glaucius

“…The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent…”
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Discovery of an imidazonaphthyridine and a riminophenazine as potent anti-Zika virus agents through a replicon-based high-throughput screening by Fernandes, Rafaela Sachetto, de Godoy, Andre Schutzer, Santos, Igor Andrade, Noske, Gabriela Dias, de Oliveira, Ketllyn Irene Zagato, Gawriljuk, Victor Oliveira, Gomes Jardim, Ana Carolina, Oliva, Glaucius

“…•A BHK-21 cell line expressing a ZIKV Rluc replicon was developed and characterized.•400 small-molecule compounds were screened using the…”
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An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition by Noske, Gabriela Dias, Song, Yun, Fernandes, Rafaela Sachetto, Chalk, Rod, Elmassoudi, Haitem, Koekemoer, Lizbé, Owen, C. David, El-Baba, Tarick J., Robinson, Carol V., Oliva, Glaucius, Godoy, Andre Schutzer

“…The main protease from SARS-CoV-2 (M pro ) is responsible for cleavage of the viral polyprotein. M pro self-processing is called maturation, and it is crucial…”
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Virtual screening and its integration with modern drug design technologies by Guido, Rafael V C, Oliva, Glaucius, Andricopulo, Adriano D

“…Drug discovery is a highly complex and costly process, which demands integrated efforts in several relevant aspects involving innovation, knowledge,…”
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Structure of an Odorant-Binding Protein from the Mosquito Aedes aegypti Suggests a Binding Pocket Covered by a pH-Sensitive “Lid” by Leite, Ney Ribeiro, Krogh, Renata, Xu, Wei, Ishida, Yuko, Iulek, Jorge, Leal, Walter S, Oliva, Glaucius

“…Background: The yellow fever mosquito, Aedes aegypti, is the primary vector for the viruses that cause yellow fever, mostly in tropical regions of Africa and…”
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Synthesis, Biological Evaluation, and Structure–Activity Relationships of Potent Noncovalent and Nonpeptidic Cruzain Inhibitors as Anti-Trypanosoma cruzi Agents by Ferreira, Rafaela S, Dessoy, Marco A, Pauli, Ivani, Souza, Mariana L, Krogh, Renata, Sales, Ana I. L, Oliva, Glaucius, Dias, Luiz C, Andricopulo, Adriano D

“…The development of cruzain inhibitors has been driven by the urgent need to develop novel and more effective drugs for the treatment of Chagas’ disease…”
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Sergio Mascarenhas a Polymath in Physics by Baffa, Oswaldo, Costa-Filho, Antonio, Crestana, Silvio, Oliva, Glaucius, Onuchic, José Nelson, Rezende, Sergio Machado

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Insights into the role of the cobalt(III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4 by Martins, Daniel Oliveira Silva, Souza, Rafael Aparecido Carvalho, Freire, Marjorie Caroline Liberato Cavalcanti, de Moraes Roso Mesquita, Nathalya Cristina, Santos, Igor Andrade, de Oliveira, Débora Moraes, Junior, Nilson Nicolau, de Paiva, Raphael Enoque Ferraz, Harris, Mark, Oliveira, Carolina Gonçalves, Oliva, Glaucius, Jardim, Ana Carolina Gomes

“…Chikungunya virus (CHIKV) is the causative agent of chikungunya fever, a disease that can result in disability. Until now, there is no antiviral treatment…”
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Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors by Freire, Marjorie C L C, Noske, Gabriela D, Bitencourt, Natália V, Sanches, Paulo R S, Santos-Filho, Norival A, Gawriljuk, Victor O, de Souza, Eduardo P, Nogueira, Victor H R, de Godoy, Mariana O, Nakamura, Aline M, Fernandes, Rafaela S, Godoy, Andre S, Juliano, Maria A, Peres, Bianca M, Barbosa, Cecília G, Moraes, Carolina B, Freitas-Junior, Lucio H G, Cilli, Eduardo M, Guido, Rafael V C, Oliva, Glaucius

“…The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years,…”
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Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses by Fernandes, Rafaela S., Freire, Marjorie C. L. C., Bueno, Renata V., Godoy, Andre S., Gil, Laura H. V. G., Oliva, Glaucius

“…Single-stranded positive RNA ((+) ssRNA) viruses include several important human pathogens. Some members are responsible for large outbreaks, such as Zika…”
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From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases by Ferreira, Leonardo G, Oliva, Glaucius, Andricopulo, Adriano D

“…Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This…”
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Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies by de Souza, Guilherme Eduardo, Bueno, Renata Vieira, de Souza, Juliana Oliveira, Zanini, Camila Lima, Cruz, Fábio Cardoso, Oliva, Glaucius, Guido, Rafael Victório Carvalho, Aguiar, Anna Caroline Campos

“…Artemisinin-based combination therapy (ACT) is used as the first-line treatment of uncomplicated malaria caused by the Plasmodium falciparum parasite and…”
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Amino Acid Polymorphisms on the Brazilian Strain of Yellow Fever Virus Methyltransferase Are Related to the Host's Immune Evasion Mediated by Type I Interferon by Furtado, Nathália Dias, de Mello, Iasmim Silva, de Godoy, Andre Schutzer, Noske, Gabriela Dias, Oliva, Glaucius, Canard, Bruno, Decroly, Etienne, Bonaldo, Myrna C

“…Since late 2016, a yellow fever virus (YFV) variant carrying a set of nine amino acid variations has circulated in South America. Three of them were mapped on…”
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Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate by Freire, Marjorie C. L. C., Basso, Luis G. M., Mendes, Luis F. S., Mesquita, Nathalya C. M. R., Mottin, Melina, Fernandes, Rafaela S., Policastro, Lucca R., Godoy, Andre S., Santos, Igor A., Ruiz, Uriel E. A., Caruso, Icaro P., Sousa, Bruna K. P., Jardim, Ana C. G., Almeida, Fabio C. L., Gil, Laura H. V. G., Andrade, Carolina H., Oliva, Glaucius

“…Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, an acute febrile and arthritogenic illness with no effective treatments available. The…”
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Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLpro Protein by Bitencourt, Natália Vitória, Righetto, Gabriela Marinho, Camargo, Ilana Lopes Baratella Cunha, de Godoy, Mariana Ortiz, Guido, Rafael Victorio Carvalho, Oliva, Glaucius, Santos-Filho, Norival Alves, Cilli, Eduardo Maffud

“…Recent studies have shown that the peptide [des-Cys11,Lys12,Lys13-(p-BthTX-I)2K] (p-Bth) is a p-BthTX-I analog that shows enhanced antimicrobial activity,…”
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Protein-protein interaction inhibitors: advances in anticancer drug design by Ferreira, Leonardo G, Oliva, Glaucius, Andricopulo, Adriano D

“…Pocket-based drug design has contributed to major scientific breakthroughs in pharmaceutical research and development (R&D). The integrated use of experimental…”
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Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches by Ramos, Paulo Ricardo Pimenta da Silva, Mottin, Melina, Lima, Caroline Sprengel, Assis, Letícia R, de Oliveira, Ketllyn Zagato, Mesquita, Nathalya Cristina de Moraes Roso, Cassani, Natasha Marques, Santos, Igor Andrade, Borba, Joyce Villa Verde Bastos, Fiaia Costa, Vinícius Alexandre, Neves, Bruno Junior, Guido, Rafael Victorio Carvalho, Oliva, Glaucius, Jardim, Ana Carolina Gomes, Regasini, Luis Octávio, Andrade, Carolina Horta

“…Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological consequences for infected infants and adults, there are still no approved drugs…”
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The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication by Policastro, Lucca R, Dolci, Isabela, Godoy, Andre S, Silva Júnior, José V J, Ruiz, Uriel E A, Santos, Igor A, Jardim, Ana C G, Samby, Kirandeep, Burrows, Jeremy N, Wells, Timothy N C, Gil, Laura H V G, Oliva, Glaucius, Fernandes, Rafaela S

“…Chikungunya virus (CHIKV) is the causative agent of chikungunya fever, a disabling disease that can cause long-term severe arthritis. Since the last large…”
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