Search Results - "Olins, Donald E."

Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment by Zhou, Bing-Rui, Yadav, K. N. Sathish, Borgnia, Mario, Hong, Jingjun, Cao, Baohua, Olins, Ada L., Olins, Donald E., Bai, Yawen, Zhang, Ping

“…Genomic DNA in eukaryotes is organized into chromatin through association with core histones to form nucleosomes, each distinguished by their DNA sequences and…”
Get full text

Epichromatin and chromomeres: a ‘fuzzy’ perspective by Olins, Donald E., Olins, Ada L.

“…‘Epichromatin’, the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by…”
Get full text

Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells by Jacobson, Elsie C, Perry, Jo K, Long, David S, Olins, Ada L, Olins, Donald E, Wright, Bryon E, Vickers, Mark H, O'Sullivan, Justin M

“…Mammalian cells are flexible and can rapidly change shape when they contract, adhere, or migrate. The nucleus must be stiff enough to withstand cytoskeletal…”
Get full text

Hyperosmotic stress: in situ chromatin phase separation by Olins, Ada L., Gould, Travis J., Boyd, Logan, Sarg, Bettina, Olins, Donald E.

“…Dehydration of cells by acute hyperosmotic stress has profound effects upon cell structure and function. Interphase chromatin and mitotic chromosomes collapse…”
Get full text

Chromatin history: our view from the bridge by Olins, Donald E, Olins, Ada L

“…Thirty years ago, our conception of chromatin structure underwent a total metamorphosis as the nucleosome era began. In Kurosawa's classic movie 'Rashomon'…”
Get full text

ELCS in ice: cryo-electron microscopy of nuclear envelope-limited chromatin sheets by Eltsov, Mikhail, Sosnovski, Sergey, Olins, Ada L, Olins, Donald E

“…Nuclear envelope-limited chromatin sheets (ELCS) form during excessive interphase nuclear envelope growth in a variety of cells. ELCS appear as extended sheets…”
Get full text

Lamin B receptor: Multi-tasking at the nuclear envelope by Olins, Ada L., Rhodes, Gale, Welch, David B. Mark, Zwerger, Monika, Olins, Donald E.

“…Lamin B Receptor (LBR) is an integral membrane protein of the interphase nuclear envelope (NE).  The N-terminal end resides in the nucleoplasm, binding to…”
Get full text

Linker histone epitopes are hidden by in situ higher-order chromatin structure by Teif, Vladimir B, Gould, Travis J, Clarkson, Christopher T, Boyd, Logan, Antwi, Enoch B, Ishaque, Naveed, Olins, Ada L, Olins, Donald E

“…Histone H1 is the most mobile histone in the cell nucleus. Defining the positions of H1 on chromatin in situ, therefore, represents a challenge…”
Get full text

TNF-α Differentially Regulates Cell Cycle Genes in Promyelocytic and Granulocytic HL-60/S4 Cells by Jacobson, Elsie C, Jain, Lekha, Vickers, Mark H, Olins, Ada L, Olins, Donald E, Perry, Jo K, O'Sullivan, Justin M

“…Tumor necrosis factor alpha (TNF-α) is a potent cytokine involved in systemic inflammation and immune modulation. Signaling responses that involve TNF-α are…”
Get full text

Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly) by Kaps, Reinhard, Sperling, Karl, Reis, André, Müller, Dietmar, Cruz, Norberto Sotelo, Olins, Donald E, Lucke, Barbara, Karl, Hartmut, Lindner, Tom H, Herrmann, Harald, Olins, Ada L, Ware, Russell E, Hoffmann, Katrin, Aznar, Justo, Vayá, Amparo, Dreger, Christine K, Shultz, Leonard D

“…Pelger-Huët anomaly (PHA; OMIM *169400) is an autosomal dominant disorder characterized by abnormal nuclear shape and chromatin organization in blood…”
Get full text

Nuclear envelope-limited chromatin sheets (ELCS) and heterochromatin higher order structure by Olins, Donald E, Olins, Ada L

“…The interphase nucleus and nuclear envelope can acquire a myriad of shapes in normal or pathological cell states. There exist a wide variety of indentations…”
Get full text

Granulocytic nuclear differentiation of lamin B receptor–deficient mouse EPRO cells by Zwerger, Monika, Herrmann, Harald, Gaines, Peter, Olins, Ada L, Olins, Donald E

“…Objective Lamin B receptor (LBR) is an integral protein of the inner nuclear membrane. Recent studies have demonstrated that genetic deficiency of LBR during…”
Get full text

DNA Replication: An in vivo Space–Time Continuum in the Ciliate Replication Band by Olins, Donald E., Olins, Ada L.

“…The replication band in the macronucleus of ciliated protozoa has fascinated microscopists since the 19th Century. It migrates through the nucleus,…”
Get full text

Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes by Prudovsky, Igor, Vary, Calvin P.H., Markaki, Yolanda, Olins, Ada L., Olins, Donald E.

“…Cycling eukaryotic cells rapidly re-establish the nuclear envelope and internal architecture following mitosis. Studies with a specific anti-nucleosome…”
Get full text

Mesoscale Modeling of Nucleosome-Binding Antibody PL2-6: Mono- versus Bivalent Chromatin Complexes by Myers, Christopher G., Olins, Donald E., Olins, Ada L., Schlick, Tamar

“…Interactions of chromatin with bivalent immunoglobin nucleosome-binding antibodies and their monovalent (papain-derived) antigen-binding fragment analogs are…”
Get full text

Interphase epichromatin: last refuge for the 30-nm chromatin fiber? by Xu, Peng, Mahamid, Julia, Dombrowski, Marco, Baumeister, Wolfgang, Olins, Ada L., Olins, Donald E.

“…“Interphase epichromatin” describes the surface of chromatin located adjacent to the interphase nuclear envelope. It was discovered in 2011 using a bivalent…”
Get full text

An epichromatin epitope: Persistence in the cell cycle and conservation in evolution by Olins, Ada L., Langhans, Markus, Monestier, Marc, Schlotterer, Andreas, Robinson, David G., Viotti, Corrado, Zentgraf, Hanswalter, Zwerger, Monika, Olins, Donald E.

“…Interphase nuclear architecture is disrupted and rapidly reformed with each cell division cycle. Successive cell generations exhibit a "memory" of this nuclear…”
Get full text

An in vitro model for Pelger-Huët anomaly: Stable knockdown of Lamin B receptor in HL-60 cells by Olins, Ada L., Ernst, Aurélie, Zwerger, Monika, Herrmann, Harald, Olins, Donald E.

“…The principal human blood granulocyte (neutrophil) possesses a lobulated and deformable nucleus, important to facilitate rapid egress from blood vessels as…”
Get full text

Hi-C detects novel structural variants in HL-60 and HL-60/S4 cell lines by Jacobson, Elsie C., Grand, Ralph S., Perry, Jo K., Vickers, Mark H., Olins, Ada L., Olins, Donald E., O'Sullivan, Justin M.

“…Cancer cell lines often have large structural variants (SVs) that evolve over time. There are many reported differences in large scale SVs between HL-60 and…”
Get full text

The transcriptome of acute dehydration in myeloid leukemic cells by Mark Welch, David B, Gould, Travis J, Olins, Ada L, Olins, Donald E

“…Human myeloid leukemia cells (HL-60/S4) exposed to hyperosmotic stress with sucrose undergo dehydration and cell shrinkage. Interphase chromatin and mitotic…”
Get more information