Search Results - "Olesen, SP"

KCNE4 is an inhibitory subunit to the KCNQ1 channel by Grunnet, Morten, Jespersen, Thomas, Rasmussen, Hanne Borger, Ljungstrøm, Trine, Jorgensen, Nanna K., Olesen, Søren‐Peter, Klaerke, Dan A.

“…KCNE4 is a membrane protein belonging to a family of single transmembrane domain proteins known to have dramatic effect on the gating of certain potassium…”
Get full text

KCNQ4 channel activation by BMS-204352 and retigabine by Schrøder, Rikke Louise, Jespersen, Thomas, Christophersen, Palle, Strøbæk, Dorte, Jensen, Bo Skaaning, Olesen, Søren-Peter

“…Activation of potassium channels generally reduces cellular excitability, making potassium channel openers potential drug candidates for the treatment of…”
Get full text

One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders by Jepps, TA, Olesen, SP, Greenwood, IA

“…Retigabine is a first in class anticonvulsant that has recently undergone clinical trials to test its efficacy in epileptic patients. Retigabine's novel…”
Get full text

KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology by Søgaard, R, Ljungstrøm, T, Pedersen, K A, Olesen, S P, Jensen, B S

“…Human cloned KCNQ4 channels were stably expressed in HEK-293 cells and characterized with respect to function and pharmacology. Patch-clamp measurements showed…”
Get more information

Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352 by Schrøder, Rikke Louise, Strøbaek, Dorte, Olesen, Søren-Peter, Christophersen, Palle

“…The compound BMS-204352 has been targeted for use against acute ischemic stroke, due to its activation of the large-conductance Ca2+-activated K-channel (BK)…”
Get full text

Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter by Zhong, Xi Zoë, Harhun, Maksym I., Olesen, Soren P., Ohya, Susumu, Moffatt, James D., Cole, William C., Greenwood, Iain A.

“…KCNQ gene expression was previously shown in various rodent blood vessels, where the products of KCNQ4 and KCNQ5, Kv7.4 and Kv7.5 potassium channel subunits,…”
Get full text

The KCNQ1 Potassium Channel: From Gene to Physiological Function by Jespersen, Thomas, Grunnet, Morten, Olesen, Soren-Peter

“…Thomas Jespersen 1 , Morten Grunnet 1 ,2 and Søren-Peter Olesen 1 ,2 1 Department of Medical Physiology and Danish Arrhythmia Research Center, The Panum…”
Get full text

Mechanism of action of a novel human ether-a-go-go-related gene channel activator by Casis, Oscar, Olesen, Søren-Peter, Sanguinetti, Michael C

“…1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is a newly discovered activator of human ether-a-go-go-related gene (hERG) K(+) channels. Here, we…”
Get more information

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family by JESPERSEN, Thomas, MEMBREZ, Mathieu, NICOLAS, Céline S, PITARD, Bruno, STAUB, Olivier, OLESEN, Soren-Peter, BARO, Isabelle, ABRIEL, Hugues

“…The voltage-gated KCNQ1 potassium channel regulates key physiological functions in a number of tissues. In the heart, KCNQ1 alpha-subunits assemble with KCNE1…”
Get full text

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) by Hansen, Rie Schultz, Diness, Thomas Goldin, Christ, Torsten, Demnitz, Joachim, Ravens, Ursula, Olesen, Søren-Peter, Grunnet, Morten

“…The cardiac action potential is generated by a concerted action of different ion channels and transporters. Dysfunction of any of these membrane proteins can…”
Get more information

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions by Nausch, Bernhard, Rode, Frederik, Jørgensen, Susanne, Nardi, Antonio, Korsgaard, Mads P G, Hougaard, Charlotte, Bonev, Adrian D, Brown, William D, Dyhring, Tino, Strøbæk, Dorte, Olesen, Søren-Peter, Christophersen, Palle, Grunnet, Morten, Nelson, Mark T, Rønn, Lars C B

“…Large-conductance Ca(2+)-activated K(+) channels (BK, KCa1.1, MaxiK) are important regulators of urinary bladder function and may be an attractive therapeutic…”
Get more information

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) by Strøbaek, Dorte, Teuber, Lene, Jørgensen, Tino D, Ahring, Philip K, Kjaer, Katrine, Hansen, Rie S, Olesen, Søren Peter, Christophersen, Palle, Skaaning-Jensen, Bo

“…We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels…”
Get full text

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing by Quinn, T.A., Granite, S., Allessie, M.A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R.A.B., Cerbai, E., Chen, P.S., Delmar, M., DiFrancesco, D., Earm, Y.E., Efimov, I.R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M.R., Garny, A., Giles, W.R., Hannes, T., Harding, S.E., Hunter, P.J., Iribe, G., Jalife, J., Johnson, C.R., Kass, R.S., Kodama, I., Koren, G., Lord, P., Markhasin, V.S., Matsuoka, S., McCulloch, A.D., Mirams, G.R., Morley, G.E., Nattel, S., Noble, D., Olesen, S.P., Panfilov, A.V., Trayanova, N.A., Ravens, U., Richard, S., Rosenbaum, D.S., Rudy, Y., Sachs, F., Sachse, F.B., Saint, D.A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varró, A., Volders, P.G., Wang, K., Weiss, J.N., Wettwer, E., White, E., Wilders, R., Winslow, R.L., Kohl, P.

“…Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As…”
Get full text

The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels by Bentzen, Bo Hjorth, Schmitt, Nicole, Calloe, Kirstine, Dalby Brown, William, Grunnet, Morten, Olesen, Søren-Peter

“…The family of Kv7 (KCNQ) potassium channels consists of five members. Kv7.2 and 3 are the primary molecular correlates of the M-current, but also Kv7.4 and…”
Get full text

Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea] by Hansen, Rie Schultz, Diness, Thomas Goldin, Christ, Torsten, Wettwer, Erich, Ravens, Ursula, Olesen, Søren-Peter, Grunnet, Morten

“…Within the field of new antiarrhythmic compounds, the interesting idea of activating human ether-a-go-go-related gene (HERG1) potassium channels has recently…”
Get more information

Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes by Jespersen, T, Grunnet, M, Angelo, K, Klaerke, D A, Olesen, S P

“…Both Xenopus laevis oocytes and mammalian cells are widely used for heterologous expression of several classes of proteins, and membrane proteins especially,…”
Get full text

KCNE5 Induces Time- and Voltage-Dependent Modulation of the KCNQ1 Current by Angelo, Kamilla, Jespersen, Thomas, Grunnet, Morten, Nielsen, Morten Schak, Klaerke, Dan A., Olesen, Søren-Peter

“…The function of the KCNE5 (KCNE1-like) protein has not previously been described. Here we show that KCNE5 induces both a time- and voltage-dependent modulation…”
Get full text

Client contribution in negotiations on employability - categories revised? by Eskelinen, L., Olesen, S.P., Caswell, D.

“…Eskelinen L, Olesen SP, Caswell D. Client contribution in negotiations on employability – categories revised? Int J Soc Welfare 2010: 19: 330–338 © 2010 The…”
Get full text

Pharmacological characterization of small‐conductance Ca2+‐activated K+ channels stably expressed in HEK 293 cells by Strøbæk, Dorte, Jørgensen, Tino D, Christophersen, Palle, Ahring, Philip K, Olesen, Søren‐Peter

“…Three genes encode the small‐conductance Ca2+‐activated K+ channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the…”
Get full text

Inactivation as a New Regulatory Mechanism for Neuronal Kv7 Channels by Jensen, Henrik Sindal, Grunnet, Morten, Olesen, Søren-Peter

“…Voltage-gated K + channels of the Kv7 (KCNQ) family have important physiological functions in both excitable and nonexcitable tissue. The family encompasses…”
Get full text