Search Results - "Olesen, P"

TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension by Askew Page, Henry R., Dalsgaard, Thomas, Baldwin, Samuel N., Jepps, Thomas A., Povstyan, Oleksandr, Olesen, Søren P., Greenwood, Iain A.

“…Background and Purpose Coronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the…”
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Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension by JEPPS, Thomas A, CHADHA, Preet S, DAVIS, Alison J, HARHUN, Maksym I, COCKERILL, Gillian W, OLESEN, Søren P, HANSEN, Rie S, GREENWOOD, Lain A

“…Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators…”
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Status and perspectives of biomarker validation for diagnosis, stratification, and treatment by Skov, J., Kristiansen, K., Jespersen, J., Olesen, P.

“…The aim of this study was to discuss the status of and perspective for biomarker validation in view of the challenges imposed on national healthcare systems…”
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Dietary exposure to volatile and non-volatile N-nitrosamines from processed meat products in Denmark by Herrmann, S.S., Duedahl-Olesen, L., Christensen, T., Olesen, P.T., Granby, K.

“…•Exposure to VNA and one carcinogenic NVNA via nitrite preserved meat is low.•The exposure to the NVNA is substantially higher than the VNA exposure.•Ham,…”
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Reduced KCNQ4-Encoded Voltage-Dependent Potassium Channel Activity Underlies Impaired β-Adrenoceptor–Mediated Relaxation of Renal Arteries in Hypertension by Chadha, Preet S, Zunke, Friederike, Zhu, Hai-Lei, Davis, Alison J, Jepps, Thomas A, Olesen, Søren P, Cole, William C, Moffatt, James D, Greenwood, Iain A

“…KCNQ4-encoded voltage-dependent potassium (Kv7.4) channels are important regulators of vascular tone that are severely compromised in models of hypertension…”
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The QCD scattering amplitude from area behaved Wilson loops by Makeenko, Y., Olesen, P.

“…We explicitly construct the dominant saddle-point trajectory in the sum-over-path representation of meson scattering amplitudes in large N QCD for area-behaved…”
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One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders by Jepps, TA, Olesen, SP, Greenwood, IA

“…Retigabine is a first in class anticonvulsant that has recently undergone clinical trials to test its efficacy in epileptic patients. Retigabine's novel…”
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Inverse cascades and primordial magnetic fields by Olesen, P.

“…We consider primordial spectra with simple power behaviours and show that in the Navier-Stokes and magnetohydrodynamics equations without forcing, there exists…”
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Arterial osteoprotegerin: increased amounts in diabetes and modifiable synthesis from vascular smooth muscle cells by insulin and TNF-alpha by Olesen, P, Ledet, T, Rasmussen, L M

“…Extracellular matrix modifications and linear medial calcifications are elements of diabetic macroangiopathy. We hypothesised that the bone-related protein…”
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White matter lesions and temporal lobe atrophy related to incidence of both dementia and major depression in 70-year-olds followed over 10 years by Gudmundsson, P., Olesen, P. J., Simoni, M., Pantoni, L., Östling, S., Kern, S., Guo, X., Skoog, I.

“…Background and purpose A number of studies have suggested associations between dementia and depression in older adults. One reason could be that these…”
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Increased prefrontal and parietal activity after training of working memory by Olesen, Pernille J, Westerberg, Helena, Klingberg, Torkel

“…Working memory capacity has traditionally been thought to be constant. Recent studies, however, suggest that working memory can be improved by training. In…”
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Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter by Zhong, Xi Zoë, Harhun, Maksym I., Olesen, Soren P., Ohya, Susumu, Moffatt, James D., Cole, William C., Greenwood, Iain A.

“…KCNQ gene expression was previously shown in various rodent blood vessels, where the products of KCNQ4 and KCNQ5, Kv7.4 and Kv7.5 potassium channel subunits,…”
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Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes by Jespersen, T, Grunnet, M, Angelo, K, Klaerke, D A, Olesen, S P

“…Both Xenopus laevis oocytes and mammalian cells are widely used for heterologous expression of several classes of proteins, and membrane proteins especially,…”
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A population-based study on the influence of brain atrophy on 20-year survival after age 85 by OLESEN, P. J, GUO, X, GUSTAFSON, D, BÖRJESSON-HANSON, A, SACUIU, S, ECKERSTROM, C, BIGLER, E. D, SKOOG, I

“…Individuals aged 80 years and older is the fastest growing segment of the population worldwide. To understand the biology behind increasing longevity, it is…”
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Electrophysiological determinants of hypokalaemia-induced arrhythmogenicity in the guinea-pig heart by Osadchii, O.E, Olesen, S.P

“…Hypokalaemia is an independent risk factor contributing to arrhythmic death in cardiac patients. In the present study, we explored the mechanisms of…”
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Brain Activity Related to Working Memory and Distraction in Children and Adults by Olesen, Pernille J., Macoveanu, Julian, Tegnér, Jesper, Klingberg, Torkel

“…In order to retain information in working memory (WM) during a delay, distracting stimuli must be ignored. This important ability improves during childhood,…”
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The Ca2+-activated K+ channel of intermediate conductance: a molecular target for novel treatments? by Jensen, B S, Strøbaek, D, Olesen, S P, Christophersen, P

“…This review discusses the Ca2+-activated K+ channels of intermediate conductance (IK channels), and their historical discovery in erythrocytes, their classical…”
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Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart by Killeen, M.J, Thomas, G, Olesen, S.-P, Demnitz, J, Stokoe, K.S, Grace, A.A, Huang, C.L.-H

“…We explored the anti-arrhythmic efficacy of K⁺ channel activation in the hypokalaemic murine heart using NS1643 and nicorandil, compounds which augment IKr and…”
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Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing by Quinn, T.A., Granite, S., Allessie, M.A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R.A.B., Cerbai, E., Chen, P.S., Delmar, M., DiFrancesco, D., Earm, Y.E., Efimov, I.R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M.R., Garny, A., Giles, W.R., Hannes, T., Harding, S.E., Hunter, P.J., Iribe, G., Jalife, J., Johnson, C.R., Kass, R.S., Kodama, I., Koren, G., Lord, P., Markhasin, V.S., Matsuoka, S., McCulloch, A.D., Mirams, G.R., Morley, G.E., Nattel, S., Noble, D., Olesen, S.P., Panfilov, A.V., Trayanova, N.A., Ravens, U., Richard, S., Rosenbaum, D.S., Rudy, Y., Sachs, F., Sachse, F.B., Saint, D.A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varró, A., Volders, P.G., Wang, K., Weiss, J.N., Wettwer, E., White, E., Wilders, R., Winslow, R.L., Kohl, P.

“…Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As…”
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Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells by Rasmussen, L M, Hansen, P R, Nabipour, M T, Olesen, P, Kristiansen, M T, Ledet, T

“…The expression of monocyte adhesion molecules, such as VCAM-1 (vascular cell adhesion molecule-1) and E-selectin, on the surface of the endothelium is an…”
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