Search Results - "Olesen, M. S."

High prevalence of genetic variants previously associated with Brugada syndrome in new exome data by Risgaard, B, Jabbari, R, Refsgaard, L, Holst, AG, Haunsø, S, Sadjadieh, A, Winkel, BG, Olesen, MS, Tfelt-Hansen, J

“…More than 300 variants in 12 genes have been associated with Brugada syndrome (BrS) which has a prevalence ranging between 1:2000 and 1:100,000. Until…”
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Distinguishing pathogenic mutations from background genetic noise in cardiology: The use of large genome databases for genetic interpretation by Ghouse, J., Skov, M.W., Bigseth, R.S., Ahlberg, G., Kanters, J.K., Olesen, M.S.

“…Advances in clinical genetic testing have led to increased insight into the human genome, including how challenging it is to interpret rare genetic variation…”
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Integration of 60,000 exomes and ACMG guidelines question the role of Catecholaminergic Polymorphic Ventricular Tachycardia‐associated variants by Paludan‐Müller, C., Ahlberg, G., Ghouse, J., Herfelt, C., Svendsen, J.H., Haunsø, S., Kanters, J.K., Olesen, M.S.

“…Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a highly lethal cardiac arrhythmia disease occurring during exercise or psychological stress…”
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Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population by Nielsen, Jonas B, Graff, Claus, Rasmussen, Peter V, Pietersen, Adrian, Lind, Bent, Olesen, Morten S, Struijk, Johannes J, Haunsø, Stig, Svendsen, Jesper H, Køber, Lars, Gerds, Thomas A, Holst, Anders G

“…Using a large, contemporary primary care population we aimed to provide absolute long-term risks of cardiovascular death (CVD) based on the QTc interval and to…”
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Incomplete right bundle branch block: a novel electrocardiographic marker for lone atrial fibrillation by Nielsen, Jonas Bille, Olesen, Morten Salling, Tangø, Mogens, Haunsø, Stig, Holst, Anders Gaarsdal, Svendsen, Jesper Hastrup

“…P-wave morphology and PR interval have both been previously associated with atrial fibrillation (AF). We hypothesized that incomplete right bundle branch block…”
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Dissecting genetics in hypothyroidism as an independent risk factor in atherosclerotic disease by Rand, S, Haunsoe, S, Olesen, M S, Ghouse, J

“…Abstract Background Thyroid disease comprises a joint group of diseases estimated to affect 10% of the general adult population [1]. Hypothyroidism is…”
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Proteomic and genomic evaluation of plasma protein biomarkers for atrial fibrillation by Vad, O B, Paludan-Muller, C, Diederichsen, S Z, Svendsen, J H, Olesen, M S

“…Abstract Background Atrial fibrillation (AF) is a common arrhythmia and an important cause of ischemic stroke. Several plasma proteins have been suggested as…”
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Early-onset atrial fibrillation is a risk marker for cardiomyopathy: genetic insights from the UK Biobank by Bech, Q, Vad, O B, Paludan-Muller, C, Svendsen, J H, Olesen, M S

“…Abstract Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia associated with an increased risk of stroke, heart failure and premature death…”
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Potential use of pharmacogenetics in cardiology: genome-wide association studies of amiodarone-induced thyroid disorders by Rand, S, Tragante, V, Sorensen, E, Ostrowski, S R, Pedersen, O B, Olesen, M S, Bundgaard, H, Ghouse, J

“…Abstract Background Amiodarone is a commonly prescribed antiarrhythmic drug used to manage supraventricular and ventricular arrhythmias. The use of amiodarone…”
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Genome-wide association study of amidoarone-induced hypothyroidism by Rand, S, Olesen, M S, Ostrowski, S R, Sorensen, E, Pedersen, O B, Bundgaard, H, Ghouse, J

“…Abstract Background Amiodarone is a commonly prescribed antiarrhythmic drug used to manage supraventricular and ventricular arrhythmias. The use of amiodarone…”
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Genome-wide association study of atrial fibrillation in 114,539 Finnish individuals reveals novel locus associated with cardiac remodelling by Paludan-Muller, C, Vad, O B, Svendsen, J H, Olesen, M S

“…Abstract Background/Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia and it is associated with serious complications, such as…”
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Circadian rhythm in atrial fibrillation detected by implantable loop recorder: a post-hoc analysis of a randomized clinical trial by Spona, D, Haugan, K J, Graff, C, Hoejberg, S, Krieger, D, Brandes, A, Koeber, L, Olesen, M S, Svendsen, J H, Diederichsen, S Z

“…Abstract Introduction Previous studies suggest the existence of circadian, weekly, and seasonal rhythms in the occurrence of atrial fibrillation (AF), which…”
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Genome-wide multi-trait analysis on cardioembolic stroke identifies 47 novel loci by Meseguer Monfort, L, Ahlberg, G, Andreasen, L, Ghouse, J, Haunso, S, Bundgaard, H, Svendsen, J H, Olesen, M S

“…Abstract Background Ischemic stroke is one of the leading causes of death and disability-adjusted life-years worldwide. It has several subtypes and…”
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The rs13376333 risk allele mimics the effect of atrial fibrillation on SK-current density and afterdepolarizations in human atrial myocytes by Jimenez-Sabado, V, Tarifa, C, Casabella-Ramon, S, Montiel, J, Rodriguez-Font, E, Olesen, M S, Hove-Madsen, L

“…Abstract Background Various genome wide association studies have associated the single nucleotide polymorphism (SNP) rs13376333 with increased risk of atrial…”
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Atrial fibrillation screening to prevent stroke in persons with low-normal thyrotropin by Diederichsen, S Z, Spona, D, Frodi, D M, Xing, L Y, Kongebro, E K, Haugan, K J, Graff, C, Hoejberg, S, Krieger, D, Brandes, A, Koeber, L, Olesen, M S, Andersen, A, Haedersdal, S, Frikke-Schmidt, R

“…Abstract Background Screening for atrial fibrillation (AF) has been proposed as a method to prevent strokes in high-risk individuals. Recent trials were unable…”
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Screening for atrial fibrillation to prevent stroke in elderly individuals with or without preexisting cardiovascular disease by Xing, L Y, Diederichsen, S Z, Hojberg, S, Krieger, D W, Graff, C, Olesen, M S, Brandes, A, Kober, L, Haugan, K J, Svendsen, J H

“…Abstract Background Previous research has showed that various cardiovascular diseases (CVD) are associated with increased risks of atrial fibrillation (AF) and…”
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Genome-wide association study on cerebral white-matter hyperintensities in 36,577 individuals by Jespersen, J, Ahlberg, G, Andreasen, L, Ghouse, J, Frederiksen, K S, Haunsoe, S, Svendsen, J H, Frikke-Schmidt, R, Olesen, M S, Bundgaard, H

“…Abstract Background/Introduction A quarter of all strokes are caused by cerebral small vessel disease (CSVD), which is also the most common pathology…”
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High prevalence of deleterious variants in cardiomyopathy genes in patients with early onset atrial fibrillation by Vad, O B, Ahlberg, G, Paludan-Muller, C, Refsgaard, L, Sajadieh, A, Haunsoe, S, Bundgaard, H, Svendsen, J H, Olesen, M S

“…Abstract Background Atrial Fibrillation (AF) is a common cardiac arrhythmia associated with increased morbidity and mortality. AF has a significant heritable…”
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P6269Early glycemic changes after initiation of oral anti-diabetic medication and risk of major adverse cardiovascular events: results from a large primary care population of patients with type 2 diabetes by Ghouse, J, Skov, M W, Olesen, M S, Holst, A G, Nielsen, J B

“…Abstract Background Results from randomized trials in patients with type 2 diabetes have led to concerns regarding the safety and efficacy of aiming for…”
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Loss-of-function variants in founder population highlight atrial myopathy as susceptibility to atrial fibrillation by Paludan-Muller, C, Vad, O B, Kahnert, K, Ahlberg, G, Monfort, L M, Rand, S A, Trudsoe, L C, Andreasen, L, Christensen, A H, Bundgaard, H, Lundby, A, Svendsen, J H, Olesen, M S

“…Abstract Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it's associated with genes responsible for cardiac conduction,…”
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