Search Results - "Oles, R."

Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element by Lewis, Kenneth T., Oles, Lily R., MacDougald, Ormond A.

“…Tamoxifen is widely used for inducible Cre-LoxP systems but has several undesirable side effects for researchers investigating metabolism or energy balance,…”
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Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents by Field, M. J., Oles, R. J., Lewis, A. S., McCleary, S, Hughes, J, Singh, L

“…1 Gabapentin (neurontin) is a novel antiepileptic agent that binds to the α2δ subunit of voltage‐dependent calcium channels. The only other compound known to…”
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The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine by SINGH, L, FIELD, M. J, FERRIS, P, HUNTER, J. C, OLES, R. J, WILLIAMS, R. G, WOODRUFF, G. N

“…This report describes the activity of the antiepileptic agent gabapentin (Neurontin) in animal models predictive of anxiolysis and analgesia. Gabapentin…”
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Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity by Field, Mark J, Oles, Ryszard J, Singh, Lakhbir

“…The present study examines the effect of pregabalin (previously S‐Isobutylgaba and CI‐1008) in two distinct rat models of anxiety. Pregabalin binds with high…”
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Discharge with Home Health Care is Associated with Increased Complications, Readmission, and Mortality Following Total Shoulder Arthroplasty by Oles, Alexander R., Guareschi, Alexander S., Rogalski, Brandon L., Eichinger, Josef K., Friedman, Richard J.

“…Patients undergoing primary anatomic and reverse total shoulder arthroplasty (TSA) are often discharged with home health care (HHC) to provide access to…”
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The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor by Tricklebank, M D, Singh, L, Oles, R J, Preston, C, Iversen, S D

“…The selective non-competitive NMDA receptor antagonist, MK-801, potently blocked convulsions induced in the mouse by N-methyl-DL-aspartic acid (NMDLA) with an…”
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Bombesin-like peptides depolarize rat hippocampal interneurones through interaction with subtype 2 bombesin receptors by Lee, K., Dixon, A. K., Gonzalez, I., Stevens, E. B., McNulty, S., Oles, R., Richardson, P. J., Pinnock, R. D., Singh, L.

“…Whole-cell patch-clamp recordings were made from visually identified hippocampal interneurones in slices of rat brain tissue in vitro. Bath application of the…”
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Modulation of seizure susceptibility in the mouse by the strychnine‐insensitive glycine recognition site of the NMDA receptor/ion channel complex by Singh, L., Oles, R.J., Tricklebank, M.D.

“…1 In order to determine whether the strychnine‐insensitive glycine modulatory site on the N‐methyl‐d‐aspartate (NMDA) receptor/ion channel complex is fully…”
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Enantiomers of HA-966 (3-Amino-1-Hydroxypyrrolid-2-One) Exhibit Distinct Central Nervous System Effects: (+)-HA-966 is a Selective Glycine/N- Methyl-D-Aspartate Receptor Antagonist, But (-)-HA-966 is a Potent γ-Butyrolactone-Like Sedative by Singh, L., Donald, A. E., Foster, A. C., Hutson, P. H., Iversen, L. L., Iversen, S. D., Kemp, J. A., Leeson, P. D., Marshall, G. R., Oles, R. J., Priestley, T., Thorn, L., Tricklebank, M. D., Vass, C. A., Williams, B. J.

“…The antagonist effect of (±)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs through a selective interaction with…”
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The behavioural properties of CI‐988, a selective cholecystokininB receptor antagonist by Singh, Lakhbir, Field, Mark J., Hughes, John, Menzies, Richard, Oles, Ryszard J., Vass, Caroline A., Woodruff, Geoffrey N.

“…1 The behavioural effects of a selective cholecystokininB (CCKB) receptor antagonist CI‐988 were investigated in rodents. 2 In three rodent tests of anxiety…”
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Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain by Field, M J, Carnell, A J, Gonzalez, M I, McCleary, S, Oles, R J, Smith, R, Hughes, J, Singh, L

“…Enadoline is a highly selective and potent kappa-opioid receptor agonist. This report describes and compares the activities of enadoline and morphine in a rat…”
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Effect of CCK receptor antagonists on the antinociceptive, reinforcing and gut motility properties of morphine by Singh, L., Oles, R.J., Field, M.J., Atwal, P., Woodruff, G.N., Hunter, J.C.

“…1 The ability of a selective CCKA receptor antagonist PD 140548 and a selective CCKB receptor antagonist CI‐988 (formerly PD 134308) to modulate the various in…”
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Evaluation of PD 154075, a tachykinin NK1 receptor antagonist, in a rat model of postoperative pain by GONZALEZ, M. I, FIELD, M. J, HOLLOMAN, E. F, HUGHES, J, OLES, R. J, SINGH, L

“…PD 154075 ([(2-benzofuran)-CH2OCO]-(R)-alpha-MeTrp-(S)-NHCH(CH3) Ph) is a selective tachykinin NK1 receptor antagonist. Its effect on development and…”
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Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain by Tricklebank, M D, Singh, L, Jackson, A, Oles, R J

“…Lithium inhibits myo-inositol mono- and polyphosphatase activity in brain at concentrations similar to those optimal for the treatment of manic depressive…”
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Modulation of the in vivo actions of morphine by the mixed CCKA/B receptor antagonist PD 142898 by SINGH, L, FIELD, M. J, HUNTER, J. C, OLES, R. J, WOODRUFF, G. N

“…The ability of a mixed CCKA/B receptor antagonist PD 142898 (benzenebutanic acid, beta-[[3-(1 H-indol-3-yl)-2-methyl-2-[[[(2-methyl-…”
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A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine by Tricklebank, M D, Singh, L, Oles, R J, Wong, E H, Iversen, S D

“…Ketamine and (+)-N-allylnormetazocine ((+)-NANM) were found to generalize in a rat operant drug discrimination paradigm to the interoceptive stimulus induced…”
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A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse by Singh, L, Oles, R J, Vass, C A, Woodruff, G N

“…A seizure model involving slow i.v. infusion of the excitatory amino acid N-methyl-DL-aspartate (NMDLA) in the mouse is described. It allows determination of…”
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Occlusal adjustment by Oles, R D

“…Occlusal adjustment is a misunderstood and underutilized procedure that is often indicated in the management of occlusion-related disorders. To clarify the…”
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Immediate implant post-surgical complications by Ibbott, C G, Oles, R D

“…Immediate surgical implants provide a convenient means of replacing missing teeth without requiring hard tissue reduction of restoration-free potential fixed…”
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Anticonvulsant agents, dizocilpine maleate, enadoline and HA 966 have different effects on N-methyl-DL-aspartate-induced immediate early gene induction in mice by Woodburn, V L, Oles, R, Poat, J, Woodruff, G N, Hughes, J

“…Administration of N-methyl-DL-aspartate (85 mg/ml) was given by infusion (0.14 ml/min) until a clonic seizure was elicited. In situ hybridization was used to…”
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