Search Results - "Oleksy, Arkadiusz"

Mechanochemical control of epidermal stem cell divisions by B-plexins by Jiang, Chen, Javed, Ahsan, Kaiser, Laura, Nava, Michele M., Xu, Rui, Brandt, Dominique T., Zhao, Dandan, Mayer, Benjamin, Fernández-Baldovinos, Javier, Zhou, Luping, Höß, Carsten, Sawmynaden, Kovilen, Oleksy, Arkadiusz, Matthews, David, Weinstein, Lee S., Hahn, Heidi, Gröne, Hermann-Josef, Graumann, Peter L., Niessen, Carien M., Offermanns, Stefan, Wickström, Sara A., Worzfeld, Thomas

“…The precise spatiotemporal control of cell proliferation is key to the morphogenesis of epithelial tissues. Epithelial cell divisions lead to tissue crowding…”
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Finding a fitting shoe for Cinderella: Searching for an autophagy inhibitor by Miller, Simon, Oleksy, Arkadiusz, Perisic, Olga, Williams, Roger L.

“…Vps34 is the ancestral phosphatidylinositol 3-kinase (PtdIns3K) isoform and is essential for endosomal trafficking of proteins to the vacuole/lysosome,…”
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Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain by Burgess, Selena G., Oleksy, Arkadiusz, Cavazza, Tommaso, Richards, Mark W., Vernos, Isabelle, Matthews, David, Bayliss, Richard

“…The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity…”
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The many faces of protease-protein inhibitor interaction by Otlewski, Jacek, Jelen, Filip, Zakrzewska, Malgorzata, Oleksy, Arkadiusz

“…Proteases and their natural protein inhibitors are among the most intensively studied protein–protein complexes. There are about 30 structurally distinct…”
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High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting by Ullman, Christopher, Mathonet, Pascale, Oleksy, Arkadiusz, Diamandakis, Agata, Tomei, Licia, Demartis, Anna, Nardi, Chiara, Sambucini, Sonia, Missineo, Antonino, Alt, Karen, Hagemeyer, Christoph E, Harris, Matt, Hedt, Amos, Weis, Roland, Gehlsen, Kurt R

“…Abdurins are a novel antibody-like scaffold derived from the engineering of a single isolated CH2 domain of human IgG. Previous studies established the…”
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PDZ domains - common players in the cell signaling by Jeleń, Filip, Oleksy, Arkadiusz, Smietana, Katarzyna, Otlewski, Jacek

“…PDZ domains are ubiquitous protein interaction modules that play a key role in cellular signaling. Their binding specificity involves recognition of the…”
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The Structure of the N-Terminal Domain of the Product of the Lissencephaly Gene Lis1 and Its Functional Implications by Kim, Myung Hee, Cooper, David R., Oleksy, Arkadiusz, Devedjiev, Yancho, Derewenda, Urszula, Reiner, Orly, Otlewski, Jacek, Derewenda, Zygmunt S.

“…Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons…”
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The Molecular Basis of RhoA Specificity in the Guanine Nucleotide Exchange Factor PDZ-RhoGEF by Oleksy, Arkadiusz, Opaliński, Łukasz, Derewenda, Urszula, Derewenda, Zygmunt S., Otlewski, Jacek

“…The Dbl homology nucleotide exchange factors (GEFs) activate Rho family cytosolic GTPases in a variety of physiological and pathophysiological events. These…”
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Rab11‐FIP3 Is Critical for the Structural Integrity of the Endosomal Recycling Compartment by Horgan, Conor P., Oleksy, Arkadiusz, Zhdanov, Alexander V., Lall, Patrick Y., White, Ian J., Khan, Amir R., Futter, Clare E., McCaffrey, John G., McCaffrey, Mary W.

“…Rab11‐FIP3 is an endosomal recycling compartment (ERC) protein that is implicated in the process of membrane delivery from the ERC to sites of membrane…”
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Nanobody inhibitors of Plexin-B1 identify allostery in plexin–semaphorin interactions and signaling by Cowan, Richard, Trokter, Martina, Oleksy, Arkadiusz, Fedorova, Marina, Sawmynaden, Kovilen, Worzfeld, Thomas, Offermanns, Stefan, Matthews, David, Carr, Mark D., Hall, Gareth

“…Plexin-B1 is a receptor for the cell surface semaphorin, Sema4D. This signaling system has been implicated in a variety of human diseases, including cancer,…”
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Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34 by Miller, Simon, Tavshanjian, Brandon, Oleksy, Arkadiusz, Perisic, Olga, Houseman, Benjamin T, Shokat, Kevan M, Williams, Roger L

“…Phosphoinositide 3-kinases (PI3Ks) are lipid kinases with diverse roles in health and disease. The primordial PI3K, Vps34, is present in all eukaryotes and has…”
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An antagonistic monoclonal anti–Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis by Vogler, Melanie, Oleksy, Arkadiusz, Schulze, Sabrina, Fedorova, Marina, Kojonazarov, Baktybek, Nijjar, Sharandip, Patel, Seema, Jossi, Sian, Sawmynaden, Kovilen, Henry, Maud, Brown, Richard, Matthews, David, Offermanns, Stefan, Worzfeld, Thomas

“…Osteoporosis and multiple sclerosis are highly prevalent diseases with limited treatment options. In light of these unmet medical needs, novel therapeutic…”
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The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle by Derewenda, Urszula, Oleksy, Arkadiusz, Stevenson, Andra S, Korczynska, Justyna, Dauter, Zbigniew, Somlyo, Andrew P, Otlewski, Jacek, Somlyo, Avril V, Derewenda, Zygmunt S

“…Calcium sensitization in smooth muscle is mediated by the RhoA GTPase, activated by hitherto unspecified nucleotide exchange factors (GEFs) acting downstream…”
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The Crystal Structure of RhoA in Complex with the DH/PH Fragment of PDZRhoGEF, an Activator of the Ca2+ Sensitization Pathway in Smooth Muscle by Derewenda, Urszula, Oleksy, Arkadiusz, Stevenson, Andra S., Korczynska, Justyna, Dauter, Zbigniew, Somlyo, Andrew P., Otlewski, Jacek, Somlyo, Avril V., Derewenda, Zygmunt S.

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Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor by Miller, Simon, Oleksy, Arkadiusz, Perisic, Olga, Williams, Roger L

“…Vps34 is the ancestral phosphatidylinositol 3-kinase (PtdIns3K) isoform and is essential for endosomal trafficking of proteins to the vacuole/lysosome,…”
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Novel peptide recognized by RhoA GTPase by Drulis-Fajdasz, Dominika, Jelen, Filip, Oleksy, Arkadiusz, Otlewski, Jacek

“…A phage-displayed random 7-mer disulfide bridge-constrained peptide library was used to map the surface of the RhoA GTPase and to find peptides able to…”
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Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF by Oleksy, Arkadiusz, Barton, Holly, Devedjiev, Yancho, Purdy, Michael, Derewenda, Urszula, Otlewski, Jacek, Derewenda, Zygmunt S.

“…PDZ‐containing RhoGEF (PDZ‐RhoGEF) is a multidomain protein composed of 1522 amino acids that belongs to the guanine nucleotide exchange factors family (GEF)…”
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The Crystal Structure of RhoA in Complex with the DH/PH Fragment of PDZRhoGEF, an Activator of the Ca 2+ Sensitization Pathway in Smooth Muscle by Derewenda, Urszula, Oleksy, Arkadiusz, Stevenson, Andra S., Korczynska, Justyna, Dauter, Zbigniew, Somlyo, Andrew P., Otlewski, Jacek, Somlyo, Avril V., Derewenda, Zygmunt S.

“…Calcium sensitization in smooth muscle is mediated by the RhoA GTPase, activated by hitherto unspecified nucleotide exchange factors (GEFs) acting downstream…”
Get full text