Search Results - "Olechnowicz, Sam W. Z."

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  1. 1

    Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway by Olechnowicz, Sam W Z, Fedele, Anthony O, Peet, Daniel J

    Published in PloS one (07-09-2012)
    “…The transcriptional response to hypoxia is largely dependent on the Hypoxia Inducible Factors (HIF-1 and HIF-2) in mammalian cells. Many target genes have been…”
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    Journal Article
  2. 2

    Contributions of the Host Microenvironment to Cancer-Induced Bone Disease by OLECHNOWICZ, Sam W. Z, EDWARDS, Claire M

    Published in Cancer research (Chicago, Ill.) (15-03-2014)
    “…The bone marrow provides a specialized and highly supportive microenvironment for tumor growth and development of the associated bone disease. It is a…”
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    Journal Article
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    Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment by Olechnowicz, Sam W. Z., Weivoda, Megan M., Lwin, Seint T., Leung, Szi K., Gooding, Sarah, Nador, Guido, Javaid, Muhammed Kassim, Ramasamy, Karthik, Rao, Srinivasa R., Edwards, James R., Edwards, Claire M.

    Published in Scientific reports (02-10-2019)
    “…Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM…”
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  5. 5

    Small Animal Video Tracking for Activity and Path Analysis Using a Novel Open-Source Multi-Platform Application (AnimApp) by Rao, Srinivasa R., Olechnowicz, Sam W. Z., Krätschmer, Patrick, Jepson, James E. C., Edwards, Claire M., Edwards, James R.

    Published in Scientific reports (26-08-2019)
    “…Experimental biological model system outcomes such as altered animal movement capability or behaviour are difficult to quantify manually. Existing automatic…”
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  6. 6

    The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo by Gámez, Beatriz, Morris, Emma V., Olechnowicz, Sam W.Z., Webb, Siobhan, Edwards, James R., Sowman, Aneka, Turner, Christina J., Edwards, Claire M.

    Published in Translational oncology (01-01-2022)
    “…•Metformin has unexpected indirect effects on the bone microenvironment to promote myeloma.•Pretreatment with metformin indirectly increases myeloma tumour…”
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    Journal Article
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