Search Results - "Olechnowicz, Sam W. Z."
-
1
Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway
Published in PloS one (07-09-2012)“…The transcriptional response to hypoxia is largely dependent on the Hypoxia Inducible Factors (HIF-1 and HIF-2) in mammalian cells. Many target genes have been…”
Get full text
Journal Article -
2
Contributions of the Host Microenvironment to Cancer-Induced Bone Disease
Published in Cancer research (Chicago, Ill.) (15-03-2014)“…The bone marrow provides a specialized and highly supportive microenvironment for tumor growth and development of the associated bone disease. It is a…”
Get full text
Journal Article -
3
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
Published in Nature communications (04-10-2019)“…Multiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts bone homeostasis causing skeletal damage and pain. Mechanisms underlying…”
Get full text
Journal Article -
4
Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment
Published in Scientific reports (02-10-2019)“…Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM…”
Get full text
Journal Article -
5
Small Animal Video Tracking for Activity and Path Analysis Using a Novel Open-Source Multi-Platform Application (AnimApp)
Published in Scientific reports (26-08-2019)“…Experimental biological model system outcomes such as altered animal movement capability or behaviour are difficult to quantify manually. Existing automatic…”
Get full text
Journal Article -
6
The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo
Published in Translational oncology (01-01-2022)“…•Metformin has unexpected indirect effects on the bone microenvironment to promote myeloma.•Pretreatment with metformin indirectly increases myeloma tumour…”
Get full text
Journal Article -
7
A risk-reward examination of sample multiplexing reagents for single cell RNA-Seq
Published in Genomics (San Diego, Calif.) (01-03-2024)“…Single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for understanding cellular heterogeneity and function. However the choice of sample…”
Get full text
Journal Article