Search Results - "Oldham, Michael L."

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans by Jin, Mi Sun, Oldham, Michael L., Zhang, Qiuju, Chen, Jue

“…Biochemical and structural analysis of the drug transporter P-glycoprotein in Caenorhabditis elegans at a resolution of 3.4 angstroms is used to generate a…”
Get full text

Crystal Structure of the Maltose Transporter in a Pretranslocation Intermediate State by Oldham, Michael L., Chen, Jue

“…Adenosine triphosphate (ATP)—binding cassette (ABC) transporters convert chemical energy from ATP hydrolysis to mechanical work for substrate translocation…”
Get full text

Snapshots of the maltose transporter during ATP hydrolysis by Oldham, Michael L, Chen, Jue

“…ATP-binding cassette transporters are powered by ATP, but the mechanism by which these transporters hydrolyze ATP is unclear. In this study, four crystal…”
Get full text

Structure of the transporter associated with antigen processing trapped by herpes simplex virus by Oldham, Michael L, Grigorieff, Nikolaus, Chen, Jue

“…The transporter associated with antigen processing (TAP) is an ATP-binding cassette (ABC) transporter essential to cellular immunity against viral infection…”
Get full text

Structural basis for substrate specificity in the Escherichia coli maltose transport system by Oldham, Michael L., Chen, Shanshuang, Chen, Jue

“…ATP-binding cassette (ABC) transporters are molecular pumps that harness the chemical energy of ATP hydrolysis to translocate solutes across the membrane. The…”
Get full text

A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter by Oldham, Michael L., Hite, Richard K., Steffen, Alanna M., Damko, Ermelinda, Li, Zongli, Walz, Thomas, Chen, Jue

“…The cryo-electron microscopy structure of human TAP transporter, a peptide transporter central to MHC class I antigen presentation and cellular immunity, in…”
Get full text

Crystal structure of a catalytic intermediate of the maltose transporter by Quiocho, Florante A, Chen, Jue, Khare, Dheeraj, Oldham, Michael L, Davidson, Amy L

“…The maltose uptake system of Escherichia coli is a well-characterized member of the ATP-binding cassette transporter superfamily. Here we present the 2.8-A…”
Get full text

Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography by Chen, Shanshuang, Oldham, Michael L., Davidson, Amy L., Chen, Jue

“…The X-ray crystal structure of a member of the glucose-specific phosphotransferase system (EIIA Glc ) bound to the MalFGK 2 maltose transporter is presented,…”
Get full text

Alternating Access in Maltose Transporter Mediated by Rigid-Body Rotations by Khare, Dheeraj, Oldham, Michael L., Orelle, Cedric, Davidson, Amy L., Chen, Jue

“…ATP-binding cassette transporters couple ATP hydrolysis to substrate translocation through an alternating access mechanism, but the nature of the…”
Get full text

Structure and function of a HECT domain ubiquitin-binding site by Kim, Hyung Cheol, Steffen, Alanna M, Oldham, Michael L, Chen, Jue, Huibregtse, Jon M

“…The Rsp5 ubiquitin ligase contains a non‐covalent binding site for ubiquitin within the amino‐terminal lobe (N‐lobe) of the HECT domain, and the X‐ray crystal…”
Get full text

Structural basis of substrate recognition by a polypeptide processing and secretion transporter by Kieuvongngam, Virapat, Olinares, Paul Dominic B, Palillo, Anthony, Oldham, Michael L, Chait, Brian T, Chen, Jue

“…The peptidase-containing ATP-binding cassette transporters (PCATs) are unique members of the ABC transporter family that proteolytically process and export…”
Get full text

Crystal Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Dimerization Domain Reveals Evolutionary Linkage between Corona- and Arteriviridae by Yu, I-Mei, Oldham, Michael L., Zhang, Jingqiang, Chen, Jue

“…The causative agent of severe acute respiratory syndrome (SARS) is the SARS-associated coronavirus, SARS-CoV. The nucleocapsid (N) protein plays an essential…”
Get full text

Dynamics of α-helical subdomain rotation in the intact maltose ATP-binding cassette transporter by Orelle, Cédric, Alvarez, Frances Joan D, Oldham, Michael L, Orelle, Arnaud, Wiley, Theodore E, Chen, Jue, Davidson, Amy L

“…ATP-binding cassette (ABC) transporters are powered by a nucleotide-binding domain dimer that opens and closes during cycles of ATP hydrolysis. These domains…”
Get full text

Identification of a Third Osmoprotectant Transport System, the OsmU System, in Salmonella enterica by Frossard, Stephen M, Khan, Aftab A, Warrick, Eric C, Gately, Jonathan M, Hanson, Andrew D, Oldham, Michael L, Sanders, David Avram, Csonka, Laszlo N

“…The growth of Salmonella enterica serovar Typhimurium mutants lacking the ProP and ProU osmoprotectant transport systems is stimulated by glycine betaine in…”
Get full text

Principles of peptide selection by the transporter associated with antigen processing by Lee, James, Oldham, Michael L, Manon, Victor, Chen, Jue

“…Our ability to fight pathogens relies on major histocompatibility complex class I (MHC-I) molecules presenting diverse antigens on the surface of diseased…”
Get full text

The Prp19 U-box Crystal Structure Suggests a Common Dimeric Architecture for a Class of Oligomeric E3 Ubiquitin Ligases by Vander Kooi, Craig W, Ohi, Melanie D, Rosenberg, Joshua A, Oldham, Michael L, Newcomer, Marcia E, Gould, Kathleen L, Chazin, Walter J

“…Prp19 is an essential splicing factor and a member of the U-box family of E3 ubiquitin ligases. Prp19 forms a tetramer via a central coiled-coil domain. Here,…”
Get full text

Structural insights into ABC transporter mechanism by Oldham, Michael L, Davidson, Amy L, Chen, Jue

“…ATP-binding cassette (ABC) transporters utilize the energy from ATP hydrolysis to transport substances across the membrane. In recent years, crystal structures…”
Get full text

A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation by Pietz, Harlan L, Abbas, Ata, Johnson, Zachary Lee, Oldham, Michael L, Suga, Hiroaki, Chen, Jue

“…Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance protein 1 (MRP1), protect against cellular toxicity by exporting…”
Get full text

The Structure of Coral Allene Oxide Synthase Reveals a Catalase Adapted for Metabolism of a Fatty Acid Hydroperoxide by Oldham, Michael L., Brash, Alan R., Newcomer, Marcia E., Rees, Douglas C.

“…8R-Lipoxygenase and allene oxide synthase (AOS) are parts of a naturally occurring fusion protein from the coral Plexaura homomalla. AOS catalyses the…”
Get full text

Cryo-EM reconstruction of oleate hydratase bound to a phospholipid membrane bilayer by Oldham, Michael L., Zuhaib Qayyum, M., Kalathur, Ravi C., Rock, Charles O., Radka, Christopher D.

“…[Display omitted] •OhyA carboxy terminus is a membrane binding domain used for interfacial activation.•Cryo-EM dimer of dimers structure matches cryo-EM dimer…”
Get full text