Search Results - "Oldenborg, Anna"

A Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics by Tilden, Elizabeth I., Maduskar, Aditi, Oldenborg, Anna, Sabatini, Bernardo L., Chen, Yao

“…Intracellular signaling dynamics play a crucial role in cell function. Protein kinase A (PKA) is a key signaling molecule that has diverse functions, from…”
Get full text

Chromatin remodeling inactivates activity genes and regulates neural coding by Yang, Yue, Yamada, Tomoko, Hill, Kelly K., Hemberg, Martin, Reddy, Naveen C., Cho, Ha Y., Guthrie, Arden N., Oldenborg, Anna, Heiney, Shane A., Ohmae, Shogo, Medina, Javier F., Holy, Timothy E., Bonni, Azad

“…Activity-dependent transcription influences neuronal connectivity, but the roles and mechanisms of inactivation of activity-dependent genes have remained…”
Get full text

Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice by Iyer, Abhirami K, Schoch, Kathleen M, Verbeck, Anthony, Galasso, Grant, Chen, Hao, Smith, Sarah, Oldenborg, Anna, Miller, Timothy M, Karch, Celeste M, Bonni, Azad

“…Astrocyte-specific ion pump α2-Na + /K + -ATPase plays a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we test the effect of…”
Get full text

RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain by Valnegri, Pamela, Huang, Ju, Yamada, Tomoko, Yang, Yue, Mejia, Luis A., Cho, Ha Y., Oldenborg, Anna, Bonni, Azad

“…Although ubiquitin ligases have been implicated in autism, their roles and mechanisms in brain development remain incompletely understood. Here, we report that…”
Get full text

SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons by Li, Cong L, Sathyamurthy, Aruna, Oldenborg, Anna, Tank, Dharmesh, Ramanan, Narendrakumar

“…The growth of axons is an intricately regulated process involving intracellular signaling cascades and gene transcription. We had previously shown that the…”
Get full text

Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway by Smith, Sarah E., Chen, Xiaoying, Brier, Lindsey M., Bumstead, Jonathan R., Rensing, Nicholas R., Ringel, Alison E., Shin, Haewon, Oldenborg, Anna, Crowley, Jan R., Bice, Annie R., Dikranian, Krikor, Ippolito, Joseph E., Haigis, Marcia C., Papouin, Thomas, Zhao, Guoyan, Wong, Michael, Culver, Joseph P., Bonni, Azad

“…Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump…”
Get full text

Signal Regulatory Protein Alpha Is Present in Several Neutrophil Granule Populations and Is Rapidly Mobilized to the Cell Surface to Negatively Fine-Tune Neutrophil Accumulation in Inflammation by Stenberg, Åsa, Karlsson, Anna, Feuk-Lagerstedt, Elisabeth, Christenson, Karin, Bylund, Johan, Oldenborg, Anna, Vesterlund, Liselotte, Matozaki, Takashi, Sehlin, Janove, Oldenborg, Per-Arne

“…Signal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPα is…”
Get full text

Sensory experience remodels genome architecture in neural circuit to drive motor learning by Yamada, Tomoko, Yang, Yue, Valnegri, Pamela, Juric, Ivan, Abnousi, Armen, Markwalter, Kelly H., Guthrie, Arden N., Godec, Abigail, Oldenborg, Anna, Hu, Ming, Holy, Timothy E., Bonni, Azad

“…Neuronal-activity-dependent transcription couples sensory experience to adaptive responses of the brain including learning and memory. Mechanisms of…”
Get full text

Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales by Ma, Pingchuan, Chen, Peter, Tilden, Elizabeth I, Aggarwal, Samarth, Oldenborg, Anna, Chen, Yao

“…Neuromodulators transform animal behaviors. Recent research has demonstrated the importance of both sustained and transient change in neuromodulators, likely…”
Get full text

Targeted Atp1a2 knockdown by antisense oligonucleotides leads to reduced SOD1 aggregation and accelerated disease progression in the SOD1G93A mouse model of ALS by Iyer, Abhirami Kannan, Schoch, Kathleen M., Oldenborg, Anna, Chen, Hao, Smith, Sarah E, Miller, Timothy M, Karch, Celeste M., Bonni, Azad

“…Background Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease affecting the cortex, brainstem and spinal cord. In familial and sporadic…”
Get full text

The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain by Chen, Xiaoying, Chanda, Ayan, Ikeuchi, Yoshiho, Zhang, Xiaoqing, Goodman, Jared V, Reddy, Naveen C, Majidi, Shahriyar P, Wu, Dennis Y, Smith, Sarah E, Godec, Abigail, Oldenborg, Anna, Gabel, Harrison W, Zhao, Guoyan, Bonni, Shirin, Bonni, Azad

“…Control of neuronal precursor cell proliferation is essential for normal brain development, and deregulation of this fundamental developmental event…”
Get full text

Publisher Correction: Sensory experience remodels genome architecture in neural circuit to drive motor learning by Yamada, Tomoko, Yang, Yue, Valnegri, Pamela, Juric, Ivan, Abnousi, Armen, Markwalter, Kelly H., Guthrie, Arden N., Godec, Abigail, Oldenborg, Anna, Hu, Ming, Holy, Timothy E., Bonni, Azad

“…In this Letter, ‘≥’ should be ‘≤’ in the sentence: “Intra-chromosomal reads were further split into short-range reads (≥1 kb) and long-range reads (>1 kb)”…”
Get full text

TIF1γ Protein Regulates Epithelial-Mesenchymal Transition by Operating as a Small Ubiquitin-like Modifier (SUMO) E3 Ligase for the Transcriptional Regulator SnoN1 by Ikeuchi, Yoshiho, Dadakhujaev, Shorafidinkhuja, Chandhoke, Amrita S., Huynh, Mai Anh, Oldenborg, Anna, Ikeuchi, Mikako, Deng, Lili, Bennett, Eric J., Harper, J. Wade, Bonni, Azad, Bonni, Shirin

“…Epithelial-mesenchymal transition (EMT) is a fundamental cellular process that contributes to epithelial tissue morphogenesis during normal development and in…”
Get full text

Increasing Survival of Ischemic Tissue by Targeting CD47 by Isenberg, Jeff S, Romeo, Martin J, Abu-Asab, Mones, Tsokos, Maria, Oldenborg, Anna, Pappan, Loretta, Wink, David A, Frazier, William A, Roberts, David D

“…Thrombospondin-1 (TSP1) limits the angiogenic and vasodilator activities of NO. This activity of TSP1 can be beneficial in some disease states, but endogenous…”
Get full text

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation by Latour, S, Tanaka, H, Demeure, C, Mateo, V, Rubio, M, Brown, E J, Maliszewski, C, Lindberg, F P, Oldenborg, A, Ullrich, A, Delespesse, G, Sarfati, M

“…Proinflammatory molecules, including IFN-gamma and IL-12, play a crucial role in the elimination of causative agents. To allow healing, potent…”
Get full text

Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-{alpha}: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation by Latour, Sylvain, Tanaka, Hiroyuki, Demeure, Christian, Mateo, Veronique, Rubio, Manuel, Brown, Eric J, Maliszewski, Charles, Lindberg, Frederik P, Oldenborg, Anna, Ullrich, Axel, Delespesse, Guy, Sarfati, Marika

Get full text