Search Results - "Olde Rikkert, Marcel G. M"
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Quantifying resilience of humans and other animals
Published in Proceedings of the National Academy of Sciences - PNAS (20-11-2018)“…All life requires the capacity to recover from challenges that are as inevitable as they are unpredictable. Understanding this resilience is essential for…”
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Comorbidity and progression of late onset Alzheimer's disease: A systematic review
Published in PloS one (04-05-2017)“…Alzheimer's disease is a neurodegenerative syndrome characterized by multiple dimensions including cognitive decline, decreased daily functioning and…”
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The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial
Published in Alzheimer's research & therapy (05-01-2019)“…Exercise is often proposed as a non-pharmacological intervention to delay cognitive decline in people with dementia, but evidence remains inconclusive…”
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Collaborative goal setting with elderly patients with chronic disease or multimorbidity: a systematic review
Published in BMC geriatrics (31-07-2017)“…It is challenging to use shared decision-making with patients who have a chronic health condition or, especially, multimorbidity. A patient-goal-oriented…”
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Safety, pharmacodynamics, and pharmacokinetics of multiple oral doses of delta-9-tetrahydrocannabinol in older persons with dementia
Published in Psychopharmacology (01-07-2015)“…Rationale Data on safety, pharmacodynamics, and pharmacokinetics of tetrahydrocannabinol (THC) are lacking in dementia patients. Methods In this randomized,…”
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Longitudinal multiple case study on effectiveness of network-based dementia care towards more integration, quality of care, and collaboration in primary care
Published in PloS one (27-06-2018)“…This study aimed to provide insight into the merits of DementiaNet, a network-based primary care innovation for community-dwelling dementia patients…”
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Effects of aging on cerebral oxygenation during working-memory performance: a functional near-infrared spectroscopy study
Published in PloS one (28-09-2012)“…Working memory is sensitive to aging-related decline. Evidence exists that aging is accompanied by a reorganization of the working-memory circuitry, but the…”
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Technical efficiency evaluation of colorectal cancer care for older patients in Dutch hospitals
Published in PloS one (17-12-2021)“…Preoperative colorectal cancer care pathways for older patients show considerable practice variation between Dutch hospitals due to differences in…”
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The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial
Published in BMC geriatrics (22-03-2017)“…Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have…”
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The short-term effects of sedentary behaviour on cerebral hemodynamics and cognitive performance in older adults: a cross-over design on the potential impact of mental and/or physical activity
Published in Alzheimer's research & therapy (22-06-2020)“…Background Sedentary behaviour might be a potential risk factor for cognitive decline. However, the short-term effects of sedentary behaviour on (cerebro)…”
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Call for Emergency Action to Limit Global Temperature Increases, Restore Biodiversity, and Protect Health
Published in mBio (26-10-2021)Get full text
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The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer's disease: results from a randomized controlled trial
Published in Alzheimer's research & therapy (26-07-2017)“…Synaptic dysfunction contributes to cognitive impairment in Alzheimer's disease and may be countered by increased intake of nutrients that target brain…”
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Predictive validity of a two-step tool to map frailty in primary care
Published in BMC medicine (03-12-2015)“…EASY-Care Two step Older people Screening (EASY-Care TOS) is a stepped approach to identify frail older people at risk for negative health outcomes in primary…”
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Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative
Published in PloS one (15-03-2017)“…Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The…”
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Construct Validation of the Rainbow Model of Integrated Care Measurement Tool in Dutch Primary Care for Older Adults
Published in International journal of integrated care (01-01-2023)“…Care integration in primary elderly care is suboptimal. Validated instruments are needed to enable the implementation of integrated primary care. We aimed to…”
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Resilience in Clinical Care: Getting a Grip on the Recovery Potential of Older Adults
Published in Journal of the American Geriatrics Society (JAGS) (01-12-2019)“…Background Geriatricians are often confronted with unexpected health outcomes in older adults with complex multimorbidity. Aging researchers have recently…”
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Structured relearning of activities of daily living in dementia: the randomized controlled REDALI-DEM trial on errorless learning
Published in Alzheimer's research & therapy (23-03-2017)“…Errorless learning (EL) is a method for optimizing learning, which uses feed-forward instructions in order to prevent people from making mistakes during the…”
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Comparing the health state preferences of older persons, informal caregivers and healthcare professionals: a vignette study
Published in PloS one (04-03-2015)“…The Older Persons and Informal Caregivers Survey-Minimum Dataset (TOPICS-MDS) collects uniform information from research projects funded under the Dutch…”
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Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease
Published in Alzheimer's research & therapy (24-07-2015)“…Circulating levels of uridine, selenium, vitamins B12, E and C, folate, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have been shown to be lower…”
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Gait Speed and Grip Strength Reflect Cognitive Impairment and Are Modestly Related to Incident Cognitive Decline in Memory Clinic Patients With Subjective Cognitive Decline and Mild Cognitive Impairment: Findings From the 4C Study
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-06-2017)“…Prospective studies in the general population show that slow gait speed is associated with cognitive decline and clinical progression to dementia. However,…”
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