PIWI-Like 1 and PIWI-Like 2 Expression in Breast Cancer

PIWI-Like 1 and PIWI-Like 2 Expression in Breast Cancer

PIWI-like 1 and PIWI-like 2 play a role in stem cell self-renewal, and enhanced expression has been reported for several tumor entities. However, few studies have investigated PIWI-like 1 and PIWI-like 2 expressions in breast cancer subtypes regarding prognosis. Therefore, we examined protein expres...

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Published in:Cancers Vol. 12; no. 10; p. 2742
Main Authors: Erber, Ramona, Meyer, Julia, Taubert, Helge, Fasching, Peter A., Wach, Sven, Häberle, Lothar, Gaß, Paul, Schulz-Wendtland, Rüdiger, Landgraf, Laura, Olbricht, Sabrina, Jung, Rudolf, Beckmann, Matthias W., Hartmann, Arndt, Ruebner, Matthias
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-10-2020
MDPI
Subjects:
Breast cancer
Cell self-renewal
Gene expression
Genetic aspects
Germ cells
Health aspects
Immunohistochemistry
Patients
Prognosis
Protein expression
Proteins
Stem cells
Tumor cells
Tumors
Germany
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Summary:PIWI-like 1 and PIWI-like 2 play a role in stem cell self-renewal, and enhanced expression has been reported for several tumor entities. However, few studies have investigated PIWI-like 1 and PIWI-like 2 expressions in breast cancer subtypes regarding prognosis. Therefore, we examined protein expression in a large consecutive cohort of breast cancer patients and correlated it to breast cancer subtypes and survival outcome. PIWI-like 1 and PIWI-like 2 expressions were evaluated using immunohistochemistry in a cohort of 894 breast cancer patients, of whom 363 were eligible for further analysis. Percentage and intensity of stained tumor cells were analyzed and an immunoreactive score (IRS) was calculated. The interaction of PIWI-like 1 and PIWI-like 2 showed a prognostic effect on survival. For the combination of high PIWI-like 1 and low PIWI-like 2 expressions, adjusted hazard ratios (HRs) were significantly higher with regard to overall survival (OS) (HR 2.92; 95% confidence interval (CI) 1.24, 6.90), disease-free survival (DFS) (HR 3.27; 95% CI 1.48, 7.20), and distant disease-free survival (DDFS) (HR 7.64; 95% CI 2.35, 24.82). Both proteins were significantly associated with molecular-like and PAM50 subgroups. Combining high PIWI-like 1 and low PIWI-like 2 expressions predicted poorer prognosis and both markers were associated with aggressive molecular subtypes.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12102742