Search Results - "Olatunji, Lawrence A."

Enhanced hepatic glycogen synthesis and suppressed adenosine deaminase activity by lithium attenuates hepatic triglyceride accumulation in nicotine-exposed rats by Dangana, Elizabeth O., Michael, Olugbenga S., Omolekulo, Tolulope E., Areola, Emmanuel D., Olatunji, Lawrence A.

“…Reduced liver glycogen synthesis might signify increased glucose flux towards fat synthesis and triggers hepatic triglyceride accumulation and dysmetabolism…”
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Depletion of hepatic glutathione and adenosine by glucocorticoid exposure in Wistar rats is pregnancy-independent by Olatunji, Lawrence A., Badmus, Olufunto O., Abdullahi, Kamaldeen O., Usman, Taofeek O., ologe, Mary, Adejare, Abdullahi

“…Liver diseases have gained increasing attention due to their substantial impact on health, independently as well as in association with cardio-metabolic…”
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Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats by Adeyanju, Oluwaseun A., Badejogbin, Olabimpe C., Areola, Damilare E., Olaniyi, Kehinde S., Dibia, Chinaza, Soetan, Olaniyi A., Oniyide, Adesola A., Michael, Olugbenga S., Olatunji, Lawrence A., Soladoye, Ayodele O.

“…High fat diet (HFD) is a risk factor for metabolic syndrome which is characterized by overt glucose dysmetabolism and tissue derangement. The liver and…”
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Treatment with acetate during late pregnancy protects dams against testosterone-induced renal dysfunction by Olatunji, Lawrence A., Areola, Emmanuel D., Usman, Taofeek O., Badmus, Olufunto O., Olaniyi, Kehinde S.

“…Cardiometabolic diseases are complicated by renal damage. Gestational hyperandrogenism causes gestational metabolic dysfunction that is associated with fetal…”
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Elevated myocardial oxygen consumption during cutaneous cold stress in young adult overweight and obese Africans by Olaniyan, Toyib, Olatunji, Lawrence A.

“…Exaggerated sympathetic-mediated cardiovascular responses to stressful stimuli (such as cold exposure) has been linked to the development of hypertension and…”
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Suppression of HDAC by sodium acetate rectifies cardiac metabolic disturbance in streptozotocin–nicotinamide-induced diabetic rats by Olaniyi, Kehinde S, Amusa, Oluwatobi A, Areola, Emmanuel D, Olatunji, Lawrence A

“…Diabetes mellitus, particularly type 2 occurs at global epidemic proportions and leads to cardiovascular diseases. Molecular studies suggest the involvement of…”
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Neck circumference is independently associated with relative systemic hypertension in young adults with sickle cell anaemia by Olatunji, Lawrence A, Olabode, Olatunde P, Akinlade, Olawale M, Babatunde, Abiola S, Olatunji, Victoria A, Soladoye, Ayodele O

“…A seemingly interesting observation in patients with sickle cell anaemia (SCA) is that they usually have lower systemic blood pressures (BP) and insulin…”
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Rescue effect of sodium acetate in diabetes mellitus-associated testicular dysfunction is accompanied by PCSK9 modulation by Olaniyi, Kehinde S., Badejogbin, Olabimpe C., Saliu, Salam B., Olatunji, Lawrence A.

“…Diabetes mellitus (DM) is a global health burden, affecting about 463 million of the adult population worldwide. Approximately 94% of diabetic male individuals…”
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Late gestational testosterone exposure causes glucose deregulation and elevated cardiac VCAM-1 and DPP-4 activity in rats by Usman, Taofeek O., Olatunji, Lawrence A.

“…Increased vascular cell adhesion molecule-1 (VCAM-1) has been reported to be a critical link between obesity and atherosclerotic cardiovascular diseases while…”
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Involvement of glucocorticoid and mineralocorticoid receptors in lipid accumulation and depressed G6PD activity in the livers of rats treated with postpartum oral estrogen-progestin by Badmus, Olufunto O., Olatunji, Lawrence A.

“…Postpartum contraception is an important step for preventing closely spaced pregnancy. Combined oral contraceptive (COC) has been linked to cardiometabolic…”
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Sodium butyrate attenuates aortic lipotoxicity and impaired nitric oxide synthesis in female Wistar rats exposed to high-fructose drink by Oyabambi, Adewumi O., Olaniyi, Kehinde S., Olatunji, Lawrence A.

“…High fructose (HFr) intake results in dyslipidemia with consequent insulin resistance through metabolic derangements. Inadequate mobilization of excess lipid…”
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Endoglin inhibition by sodium acetate and flutamide ameliorates cardiac defective G6PD-dependent antioxidant defense in gestational testosterone-exposed rats by Olatunji, Lawrence A., Areola, Emmanuel D., Badmus, Olufunto O.

“…The graphical abstract showing the effects of late gestational testosterone exposure on cardiac G6PD-dependent anti-oxidant system, adenosine…”
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Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome by Olaniyi, Kehinde S., Areloegbe, Stephanie E., Areola, Emmanuel D., Sabinari, Isaiah W., Fafure, Adedamola A., Agbana, Richard D., Atuma, Chukwubueze L., Shah, Mohd Zahoor ul haq, Ajadi, Isaac O., Olatunji, Lawrence A.

“…Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women and it is associated with overt metabolic derangement. Circulating lipids…”
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Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy by Michael, Olugbenga S, Olatunji, Lawrence A

“…Cigarette smoking is considered to be a major risk factor for the development of diabetes and cardiovascular disease. Oestrogen-progestin combined oral…”
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Dexamethasone increases renal free fatty acids and xanthine oxidase activity in female rats: could there be any gestational impact? by Badmus, Olufunto O., Sabinari, Isaiah W., Olatunji, Lawrence A.

“…Dexamethasone (DEX) is used for various conditions in female and even during pregnancy. We tested the hypothesis that DEX exposure in female rats would lead to…”
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Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities by Usman, Taofeek O., Areola, Emmanuel D., Badmus, Olufunto O., Kim, InKyeom, Olatunji, Lawrence A.

“…Nutritional challenges and androgen excess have been implicated in the development of gestational diabetes and poor fetal outcome, but the mechanisms are not…”
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Glucocorticoid exposure causes disrupted glucoregulation, cardiac inflammation and elevated dipeptidyl peptidase-4 activity independent of glycogen synthase kinase-3 in female rats by Badmus, Olufunto O., Olatunji, Lawrence A.

“…Objective: We tested the hypothesis that glucocorticoid (GC) exposure in female rats would lead to glucose dysregulation and elevated cardiac inflammatory…”
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Suppression of uric acid and lactate production by sodium acetate ameliorates hepatic triglyceride accumulation in fructose-insulin resistant pregnant rats by Oyabambi, Adewumi O., Olaniyi, Kehinde S., Soladoye, Ayodele O., Olatunji, Lawrence A.

“…•GFED causes hepatic TG accumulation accompanied by perturbed uric acid homeostasis.•GFED-induced hepatic disorder is associated with defective G6PD…”
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Acetate-mediated-obestatin modulation attenuates adipose-hepatic dysmetabolism in high fat diet-induced obese rat model by Olaniyi, Kehinde S., Atuma, Chukwubueze L., Sabinari, Isaiah W., Mahmud, Hadiza, Saidi, Azeezat O., Fafure, Adedamola A., Olatunji, Lawrence A.

“…Purpose Approximately 650 million of world adult population is affected by obesity, which is characterized by adipose and hepatic metabolic dysfunction. Short…”
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Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone by Adeyanju, Oluwaseun A., Falodun, Timothy O., Fabunmi, Oyesanmi A., Olatunji, Lawrence A., Soladoye, Ayodele O.

“…Polycystic ovarian syndrome (PCOS) is the most common endocrinological disorder in women of reproductive age and hyperandrogenism is a prominent feature of…”
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