Search Results - "Olaniyi, Kehinde S."

Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats by Olaniyi, Kehinde S., Amusa, Oluwatobi A.

“…[Display omitted] •STZ-NA-induced diabetes mellitus (DM) progresses to hepatic lipotoxicity/injury.•DM-driven hepatic lipotoxicity is associated with increased…”
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2 by Olaniyi, Kehinde S, Areloegbe, Stephanie E

“…Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates ovarian…”
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Short chain fatty acid, acetate restores ovarian function in experimentally induced PCOS rat model by Olaniyi, Kehinde S, Bashir, Al-amin M, Areloegbe, Stephanie E, Sabinari, Isaiah W, Akintayo, Christopher O, Oniyide, Adesola A, Aturamu, Ayodeji

“…Background Polycystic ovarian syndrome (PCOS) is pathogenically characterized with hyperandrogenism and metabolic alterations, which often result in ovarian…”
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Placental Microbial Colonization and Its Association With Pre-eclampsia by Olaniyi, Kehinde S, Moodley, Jagidesa, Mahabeer, Yesholata, Mackraj, Irene

“…The existence and role of the microbiome in regulating physiological and pathophysiological conditions including metabolism, energy homeostasis, immune…”
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Low-dose spironolactone ameliorates adipose tissue inflammation and apoptosis in letrozole-induced PCOS rat model by Areloegbe, Stephanie E, Peter, Mmenyene U, Oyeleke, Mosunmola B, Olaniyi, Kehinde S

“…Abstract Background of study Globally, many reproductive aged women are affected by polycystic ovarian syndrome (PCOS), which is a common endocrine and…”
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Diacerein mitigates endocrine and cardio-metabolic disruptions in experimental PCOS mice model by modulating AdipoR1/ PON 1 by Shah, Mohd Zahoor Ul Haq, Shrivastava, Vinoy Kumar, Muzamil, Showkeen, Olaniyi, Kehinde S

“…This study aimed to explore the impact of Diacerein (DIC) on endocrine and cardio-metabolic changes in polycystic ovarian syndrome (PCOS) mouse model. A total…”
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Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model by Obayemi, Mary J, Akintayo, Christopher O, Oniyide, Adesola A, Aturamu, Ayodeji, Badejogbin, Olabimpe C, Atuma, Chukwubueze L, Saidi, Azeezat O, Mahmud, Hadiza, Olaniyi, Kehinde S

“…Adipose and hepatic metabolic dysfunctions are critical comorbidities that also aggravate insulin resistance in obese individuals. Melatonin is a low-cost…”
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Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS by Eepho, Oony-Iye, Bashir, Al-Amin M, Oniyide, Adesola A, Aturamu, Ayodeji, Owolabi, Olutunmise V, Ajadi, Isaac O, Fafure, Adedamola A, Ajadi, Mary B, Areloegbe, Stephanie E, Olaniyi, Kehinde S

“…Polycystic ovarian syndrome (PCOS) is a known endocrine disorder that has affected many women of childbearing age, and is accompanied by various…”
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Acetate attenuates hypothalamic pyroptosis in experimentally induced polycystic ovarian syndrome by Olaniyi, Kehinde S, Agan, Shalom U, Areloegbe, Stephanie E, Sabinari, Isaiah W, Oniyide, Adesola A, Enye, Linus A, Omoaghe, Adams O, Adekeye, Adeshina O, Adeoluwa, Olusegun A

“…This study hypothesized that SCFA, acetate impacts positively on hypothalamic pyroptosis and its related abnormalities in experimentally induced PCOS rat…”
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Aqueous Extract of Cola nitida and Garcinia kola Synergistically Enhances Hippocampal-hypothalamic Glutamate and Na+ /K+ -ATPase Activity in Male Wistar Rats by Olaniyi, Kehinde S, Sabinari, Isaiah W, Oniyide, Adesola A, Akinnagbe, Nifesimi T, Agunbiade, Toluwani B, Alese, Oluwole O

“…The incidence of cognitive decline has been proposed to rise exponentially in the coming years. Therapies targeting molecular pathways involved in the…”
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Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats by Adeyanju, Oluwaseun A., Badejogbin, Olabimpe C., Areola, Damilare E., Olaniyi, Kehinde S., Dibia, Chinaza, Soetan, Olaniyi A., Oniyide, Adesola A., Michael, Olugbenga S., Olatunji, Lawrence A., Soladoye, Ayodele O.

“…High fat diet (HFD) is a risk factor for metabolic syndrome which is characterized by overt glucose dysmetabolism and tissue derangement. The liver and…”
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Regulatory effects of quercetin on testicular histopathology induced by cyanide in Wistar rats by Oyewopo, Adeoye O., Adeleke, Opeyemi, Johnson, Olawumi, Akingbade, Adebanji, Olaniyi, Kehinde S., Areola, Emmanuel D., Tokunbo, Olorunfemi

“…Several causes of infertility have been identified, and several papers have documented some compounds that cause infertility. One of the compounds reported to…”
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High fructose-enriched diet synergistically exacerbates endocrine but not metabolic changes in letrozole-induced polycystic ovarian syndrome in Wistar rats by Akintayo, Christopher O., Johnson, Anjola D., Badejogbin, Olabimpe C., Olaniyi, Kehinde S., Oniyide, Adesola A., Ajadi, Isaac O., Ojewale, Abdulfatai O., Adeyomoye, Olorunsola I., Kayode, Adedeji B.

“…Polycystic Ovarian Syndrome (PCOS) is a multifactorial endocrine-metabolic disorder that highly contributes to the prevalence of infertility globally. The…”
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Treatment with acetate during late pregnancy protects dams against testosterone-induced renal dysfunction by Olatunji, Lawrence A., Areola, Emmanuel D., Usman, Taofeek O., Badmus, Olufunto O., Olaniyi, Kehinde S.

“…Cardiometabolic diseases are complicated by renal damage. Gestational hyperandrogenism causes gestational metabolic dysfunction that is associated with fetal…”
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Suppression of PCSK9/NF-kB-dependent pathways by acetate ameliorates cardiac inflammation in a rat model of polycystic ovarian syndrome by Olaniyi, Kehinde S., Areloegbe, Stephanie E.

“…Endocrinometabolic disorders in women of reproductive age, including polycystic ovarian syndrome (PCOS) has contributed to increased prevalence of…”
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Acetate mitigates cardiac mitochondrial dysfunction in experimental model of polycystic ovarian syndrome by modulating GPCR41/43 and PROKR1 by Areloegbe, Stephanie E., Olaniyi, Kehinde S.

“…The role of short chain fatty acid, acetate in cardiac mitochondrial dysfunction especially in PCOS individuals is unknown. Therefore, the present study…”
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Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3 by Olaniyi, Kehinde S., Areloegbe, Stephanie E.

“…•Polycystic ovarian syndrome causes impaired metabolic switch in skeletal muscle.•Impaired metabolic switch is mediated by elevated PDK4.•Acetate restores…”
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Cardiac energy depletion in a rat model of polycystic ovarian syndrome is reversed by acetate and associated with inhibitory effect of HDAC2/mTOR by Olaniyi, Kehinde S, Areloegbe, Stephanie E, Fiemotongha, Faustina E

“…In addition to the clinical manifestation of polycystic ovarian syndrome (PCOS), life-threatening diseases, especially hypertension and cardiovascular disease…”
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Acetate: A therapeutic candidate against renal disorder in a rat model of polycystic ovarian syndrome by Olaniyi, Kehinde S., Areloegbe, Stephanie E.

“…Various endocrinometabolic diseases, inclusively polycystic ovarian syndrome (PCOS) has been linked with increased risk of renal dysfunction with attendant…”
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Acetate restores hypothalamic-adipose kisspeptin status in a rat model of PCOS by suppression of NLRP3 immunoreactivity by Olaniyi, Kehinde S., Areloegbe, Stephanie E., Oyeleke, Mosunmola B.

“…Purpose Polycystic ovary syndrome (PCOS) is a complex reproductive event that is delineated by endocrine/metabolic disorders. Alteration of kisspeptin status…”
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