Search Results - "Olaleye, Tayo"

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    A fluorescence-based assay for N-myristoyltransferase activity by Goncalves, Victor, Brannigan, James A., Thinon, Emmanuelle, Olaleye, Tayo O., Serwa, Remigiusz, Lanzarone, Salvatore, Wilkinson, Anthony J., Tate, Edward W., Leatherbarrow, Robin J.

    Published in Analytical biochemistry (01-02-2012)
    “…N-myristoylation is the irreversible attachment of a C 14 fatty acid, myristic acid, to the N-terminal glycine of a protein via formation of an amide bond…”
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    Journal Article
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    Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites by Olaleye, Tayo O, Brannigan, James A, Roberts, Shirley M, Leatherbarrow, Robin J, Wilkinson, Anthony J, Tate, Edward W

    Published in Organic & biomolecular chemistry (07-11-2014)
    “…N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use…”
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    Journal Article
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    A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling by McCarthy, William J., Thomas, Sherine E., Olaleye, Tayo, Boland, Jennifer A., Floto, R. Andres, Williams, Glyn, Blundell, Tom L., Coyne, Anthony G., Abell, Chris

    Published in Angewandte Chemie International Edition (09-09-2024)
    “…Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting…”
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    Journal Article
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    A Fragment-Based Competitive 19 F LB-NMR Platform For Hotspot-Directed Ligand Profiling by McCarthy, William J, Thomas, Sherine E, Olaleye, Tayo, Boland, Jennifer A, Floto, R Andres, Williams, Glyn, Blundell, Tom L, Coyne, Anthony G, Abell, Chris

    Published in Angewandte Chemie International Edition (09-09-2024)
    “…Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting…”
    Get full text
    Journal Article
  9. 9

    A Fragment‐Based Competitive 19 F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling by McCarthy, William J., Thomas, Sherine E., Olaleye, Tayo, Boland, Jennifer A., Floto, R. Andres, Williams, Glyn, Blundell, Tom L., Coyne, Anthony G., Abell, Chris

    Published in Angewandte Chemie (09-09-2024)
    “…Abstract Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting…”
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    Journal Article
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    A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling by McCarthy, William J., Thomas, Sherine E., Olaleye, Tayo, Boland, Jennifer A., Floto, R. Andres, Williams, Glyn, Blundell, Tom L., Coyne, Anthony G., Abell, Chris

    Published in Angewandte Chemie (09-09-2024)
    “…Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting…”
    Get full text
    Journal Article
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    Peptidomimetic approach to the inhibition of n-myristoyltransferase, a promising parasitic drug target by Olaleye, Tayo

    Published 01-01-2012
    “…N-myristoyltransferase (NMT), a ubiquitous enzyme, found in a number of organisms including fungi, parasites and humans, catalyses the irreversible transfer of…”
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    Dissertation