Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk

Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resu...

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Bibliographic Details
Published in:	The Pediatric infectious disease journal Vol. 38; no. 7; pp. 727 - 730
Main Authors:	Nguyen, Thi Thanh Truc, Kobbe, Robin, Schulze-Sturm, Ulf, Blohm, Martin, Hollwitz, Bettina, Hertling, Sandra, Becker, Christina, Oommen, Prasad Thomas, Laws, Hans-Jürgen, Martignoni, Franca, Ole Jensen, Björn-Erik, Olah, Karen, Schmidtke, Susanne, Kreuels, Benno, Vasconcelos, Malte Kohns, Neubert, Jennifer
Format:	Journal Article
Language:	English
Published:	United States Copyright Wolters Kluwer Health, Inc. All rights reserved 01-07-2019
Subjects:	Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - prevention & control Female Hematologic Diseases - chemically induced Hematologic Diseases - epidemiology HIV Infections - prevention & control Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Male Pregnancy Retrospective Studies Zidovudine - administration & dosage Zidovudine - adverse effects
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Summary:	Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0000000000002357