Search Results - "Olafson, Hailey"

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model by Angelbello, Alicia J., Rzuczek, Suzanne G., Mckee, Kendra K., Chen, Jonathan L., Olafson, Hailey, Cameron, Michael D., Moss, Walter N., Wang, Eric T., Disney, Matthew D.

“…Myotonic dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by an expanded CTG repeat that is transcribed into r(CUG)exp. The RNA repeat…”
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Transcriptome alterations in myotonic dystrophy skeletal muscle and heart by Wang, Eric T, Treacy, Daniel, Eichinger, Katy, Struck, Adam, Estabrook, Joseph, Olafson, Hailey, Wang, Thomas T, Bhatt, Kirti, Westbrook, Tony, Sedehizadeh, Sam, Ward, Amanda, Day, John, Brook, David, Berglund, J Andrew, Cooper, Thomas, Housman, David, Thornton, Charles, Burge, Christopher

“…Abstract Myotonic dystrophy (dystrophia myotonica, DM) is a multi-systemic disease caused by expanded CTG or CCTG microsatellite repeats. Characterized by…”
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Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice by Pattamatta, Amrutha, Nguyen, Lien, Olafson, Hailey R, Scotti, Marina M, Laboissonniere, Lauren A, Richardson, Jared, Berglund, J Andrew, Zu, Tao, Wang, Eric T, Ranum, Laura P W

“…C9orf72 ALS/FTD patients show remarkable clinical heterogeneity, but the complex biology of the repeat expansion mutation has limited our understanding of the…”
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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy by Cheng, Chialin, Reis, Surya A., Adams, Emily T., Fass, Daniel M., Angus, Steven P., Stuhlmiller, Timothy J., Richardson, Jared, Olafson, Hailey, Wang, Eric T., Patnaik, Debasis, Beauchamp, Roberta L., Feldman, Danielle A., Silva, M. Catarina, Sur, Mriganka, Johnson, Gary L., Ramesh, Vijaya, Miller, Bruce L., Temple, Sally, Kosik, Kenneth S., Dickerson, Bradford C., Haggarty, Stephen J.

“…Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation…”
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Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy by Lee, Kuang-Yung, Seah, Carol, Li, Ching, Chen, Yu-Fu, Chen, Chwen-Yu, Wu, Ching-I, Liao, Po-Cheng, Shyu, Yu-Chiau, Olafson, Hailey R, McKee, Kendra K, Wang, Eric T, Yeh, Chi-Hsiao, Wang, Chao-Hung

“…Abstract Myotonic dystrophy (DM) is caused by expansions of C(C)TG repeats in the non-coding regions of the DMPK and CNBP genes, and DM patients often suffer…”
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The skeletal muscle circadian clock regulates titin splicing through RBM20 by Riley, Lance A, Zhang, Xiping, Douglas, Collin M, Mijares, Joseph M, Hammers, David W, Wolff, Christopher A, Wood, Neil B, Olafson, Hailey R, Du, Ping, Labeit, Siegfried, Previs, Michael J, Wang, Eric T, Esser, Karyn A

“…Circadian rhythms are maintained by a cell-autonomous, transcriptional-translational feedback loop known as the molecular clock. While previous research…”
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Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy by Gibaut, Quentin M. R., Bush, Jessica A., Tong, Yuquan, Baisden, Jared T., Taghavi, Amirhossein, Olafson, Hailey, Yao, Xiyuan, Childs-Disney, Jessica L., Wang, Eric T., Disney, Matthew D.

“…Myotonic dystrophy type 1 (DM1) is caused by a highly structured RNA repeat expansion, r­(CUG)exp, harbored in the 3′ untranslated region (3′ UTR) of…”
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Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models by Bush, Jessica A, Aikawa, Haruo, Fuerst, Rita, Li, Yue, Ursu, Andrei, Meyer, Samantha M, Benhamou, Raphael I, Chen, Jonathan L, Khan, Tanya, Wagner-Griffin, Sarah, Van Meter, Montina J, Tong, Yuquan, Olafson, Hailey, McKee, Kendra K, Childs-Disney, Jessica L, Gendron, Tania F, Zhang, Yongjie, Coyne, Alyssa N, Wang, Eric T, Yildirim, Ilyas, Wang, Kye Won, Petrucelli, Leonard, Rothstein, Jeffrey D, Disney, Matthew D

“…The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD) is an expanded G C RNA repeat [r(G C ) ] in chromosome 9 open…”
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