Search Results - "Olaf Nickel"

Point-of-care bulk testing for SARS-CoV-2 by combining hybridization capture with improved colorimetric LAMP by Bokelmann, Lukas, Nickel, Olaf, Maricic, Tomislav, Pääbo, Svante, Meyer, Matthias, Borte, Stephan, Riesenberg, Stephan

“…Efforts to contain the spread of SARS-CoV-2 have spurred the need for reliable, rapid, and cost-effective diagnostic methods which can be applied to large…”
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Evaluation of the systemic and mucosal immune response induced by COVID-19 and the BNT162b2 mRNA vaccine for SARS-CoV-2 by Nickel, Olaf, Rockstroh, Alexandra, Wolf, Johannes, Landgraf, Susann, Kalbitz, Sven, Kellner, Nils, Borte, Michael, Pietsch, Corinna, Fertey, Jasmin, Lübbert, Christoph, Ulbert, Sebastian, Borte, Stephan

“…The currently used SARS-CoV-2 mRNA vaccines have proven to induce a strong and protective immune response. However, functional relevance of vaccine-generated…”
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Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2 by Walluscheck, Diana, Nickel, Olaf, Phalke, Sameer, Hortig, Frank, Onorati, Maria Cristina, Reuter, Gunter

“…Gunter Reuter and colleagues show that the cytosine-5 methyltransferase DNMT2 controls retrotransposon silencing and telomere integrity in somatic cells of…”
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Evaluation of the systemic and mucosal immune response induced by COVID-19 and the BNT162b2 mRNA vaccine for SARS-CoV-2 by Olaf Nickel, Alexandra Rockstroh, Johannes Wolf, Susann Landgraf, Sven Kalbitz, Nils Kellner, Michael Borte, Corinna Pietsch, Jasmin Fertey, Christoph Lübbert, Sebastian Ulbert, Stephan Borte

“…Background The currently used SARS-CoV-2 mRNA vaccines have proven to induce a strong and protective immune response. However, functional relevance of…”
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A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2 by Maricic, Tomislav, Nickel, Olaf, Aximu-Petri, Ayinuer, Essel, Elena, Gansauge, Marie, Kanis, Philipp, Macak, Dominik, Richter, Julia, Riesenberg, Stephan, Bokelmann, Lukas, Zeberg, Hugo, Meyer, Matthias, Borte, Stephan, Pääbo, Svante

“…SARS-CoV-2 causes substantial morbidity and mortality in elderly and immunocompromised individuals, particularly in retirement homes, where transmission from…”
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Low colonization rates with Multidrug-resistant Gram-negative bacteria in a German hospital-affiliated hemodialysis center by Wendt, Ralph, Nickel, Olaf, Botsch, Almut, Lindner, Margareta, Bethge, Angela, Marx, Kathrin, Ruf, Bernhard R, Beige, Joachim, Lübbert, Christoph

“…Multidrug-resistant Gram-negative bacteria (MDRGN) are found with rising prevalence in non-hemodialysis risk populations as well as hemodialysis (HD) cohorts…”
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Evaluation of Simple Lateral Flow Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies by Nickel, Olaf, Rockstroh, Alexandra, Borte, Stephan, Wolf, Johannes

“…Immunization for the generation of protective antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged to be highly…”
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Metagenomic next-generation sequencing as a diagnostic tool in the clinical routine of an infectious diseases department: a retrospective cohort study by Kalbitz, Sven, Ermisch, Jörg, Kellner, Nils, Nickel, Olaf, Borte, Stephan, Marx, Kathrin, Lübbert, Christoph

“…Background Metagenomic next-generation sequencing (mNGS) of circulating cell-free DNA from plasma is a hypothesis-independent broadband diagnostic method for…”
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Bacterial contamination of the smartphones of healthcare workers in a German tertiary-care hospital before and during the COVID-19 pandemic by Tannhäuser, Romy, Nickel, Olaf, Lindner, Margareta, Bethge, Angela, Wolf, Johannes, Borte, Stephan, Lübbert, Christoph

“…•Bacterial contamination was present on 99.3% of the smartphone screens of HCWs.•The proportion of bacterial pathogens ranged from 21.2% in 2012 to 39.8% in…”
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Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases by Wolf, Johannes, Kaiser, Thorsten, Pehnke, Sarah, Nickel, Olaf, Lübbert, Christoph, Kalbitz, Sven, Arnold, Benjamin, Ermisch, Jörg, Berger, Luisa, Schroth, Stefanie, Isermann, Berend, Borte, Stephan, Biemann, Ronald

“…•Deep learning technology applied to diagnosis of Acute Promyelocytic Leukemia (APL).•Convolutional neural networks (Mask R-CNN) may diagnose APL in bone…”
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Comprehensive investigation of an in-hospital transmission cluster of a symptomatic SARS-CoV-2-positive physician among patients and healthcare workers in Germany by Wendt, Ralph, Nagel, Stephan, Nickel, Olaf, Wolf, Johannes, Kalbitz, Sven, Kaiser, Thorsten, Borte, Stephan, Lübbert, Christoph

“…We investigated potential transmissions of a symptomatic SARS-CoV-2-positive physician in a tertiary-care hospital who worked for 15 cumulative hours without…”
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The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu by Shanmugam, Raghuvaran, Aklujkar, Muktak, Schäfer, Matthias, Reinhardt, Richard, Nickel, Olaf, Reuter, Gunter, Lovley, Derek R, Ehrenhofer-Murray, Ann, Nellen, Wolfgang, Ankri, Serge, Helm, Mark, Jurkowski, Tomasz P, Jeltsch, Albert

“…Dnmt2 enzymes are conserved in eukaryotes, where they methylate C38 of tRNA-Asp with high activity. Here, the activity of one of the very few prokaryotic Dnmt2…”
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Reply to "Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation" by Reuter, Gunter, Phalke, Sameer, Nickel, Olaf

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Comparison of pre-analytical characteristics for molecular and serological diagnostics of COVID-19 by Wendt, Ralph, Nickel, Olaf, Kalbitz, Sven, Fertey, Jasmin, Ulbert, Sebastian, Wolf, Johannes, Lübbert, Christoph, Borte, Stephan

“…The diagnosis of SARS-CoV-2 infection relies on RT-PCR from nasopharyngeal swabs. The pre-analytical value of different methods of material harvesting for…”
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Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation/Phalke et al. reply by Schaefer, Matthias, Lyko, Frank, Phalke, Sameer, Nickel, Olaf, Reuter, Gunter

“…[...] we also extended our analysis to Invader4 LTR-containing subtelomeric repeats at chromosome 3R (previously associated with Dnmt2-dependent silencing1)…”
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