Search Results - "Oladimeji, Peter"

PXR: More Than Just a Master Xenobiotic Receptor by Oladimeji, Peter O, Chen, Taosheng

“…Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the expression of genes encoding…”
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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5 by Wright, William C, Chenge, Jude, Wang, Jingheng, Girvan, Hazel M, Yang, Lei, Chai, Sergio C, Huber, Andrew D, Wu, Jing, Oladimeji, Peter O, Munro, Andrew W, Chen, Taosheng

“…The human cytochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metabolize most drugs and have high similarities in their structure and substrate preference. Whereas…”
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RNA interference screen identifies NAA10 as a regulator of PXR transcription by Oladimeji, Peter O., Wright, William C., Wu, Jing, Chen, Taosheng

“…[Display omitted] The pregnane X receptor (PXR) is a principal xenobiotic receptor crucial in the detection, detoxification, and clearance of toxic substances…”
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KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion by Oladimeji, Peter O., Bakke, Jesse, Wright, William C., Chen, Taosheng

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. One major reason for this is that PDAC quickly metastasizes to other organs,…”
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Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase by Oladimeji, Peter O., Lin, Wenwei, Brewer, C. Trent, Chen, Taosheng

“…Pregnane X receptor (PXR) is a xenobiotic receptor that regulates the detoxification and clearance of drugs and foreign compounds from the liver. There has…”
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Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk by Oladimeji, Peter, Cui, Hongmei, Zhang, Chen, Chen, Taosheng

“…Protein-protein interaction and signaling crosstalk contribute to the regulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) and…”
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Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells by Bakke, Jesse, Wright, William C, Zamora, Anthony E, Oladimeji, Peter, Crawford, Jeremy Chase, Brewer, Christopher T, Autry, Robert J, Evans, William E, Thomas, Paul G, Chen, Taosheng

“…Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis…”
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A high-throughput screening identifies histone deacetylase inhibitors as therapeutic agents against medulloblastoma by Zhang, Shanshan, Gong, Zhaojian, Oladimeji, Peter O, Currier, Duane G, Deng, Qipan, Liu, Ming, Chen, Taosheng, Li, Yong

“…Medulloblastoma is the most frequently occurring malignant brain tumor in children. Current treatment strategies for medulloblastoma include aggressive…”
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Tyrosyl Phosphorylated PAK1 Regulates Breast Cancer Cell Motility in Response to Prolactin through Filamin A by Hammer, Alan, Rider, Leah, Oladimeji, Peter, Cook, Leslie, Li, Quanwen, Mattingly, Raymond R, Diakonova, Maria

“…The p21-activated serine-threonine kinase (PAK1) is activated by small GTPase-dependent and -independent mechanisms and regulates cell motility. Both PAK1 and…”
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Abstract 3545: Glucose-dependent regulation of PXR is modulated by AMPK by Oladimeji, Peter O.

“…The sensitivity of patients to drugs depends on the pharmacokinetics of the drugs, but largely on the bioavailability of the drugs in the body. Orally…”
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PAK1 translocates into nucleus in response to prolactin but not to estrogen by Oladimeji, Peter, Diakonova, Maria

“…Tyrosyl phosphorylation of the p21-activated serine–threonine kinase 1 (PAK1) has an essential role in regulating PAK1 functions in breast cancer cells. We…”
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PAK1 Regulates Breast Cancer Cell Invasion through Secretion of Matrix Metalloproteinases in Response to Prolactin and Three-Dimensional Collagen IV by Rider, Leah, Oladimeji, Peter, Diakonova, Maria

“…p21-Activated serine-threonine kinase (PAK1) is implicated in breast cancer. We have shown previously that PAK1 is tyrosyl phosphorylated by prolactin…”
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Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries by Tipton, Aaron R, Wang, Kexi, Oladimeji, Peter, Sufi, Shermeen, Gu, Zhidong, Liu, Song-Tao

“…Proteins functioning in the same biological pathway tend to be transcriptionally co-regulated or form protein-protein interactions (PPI). Multiple spatially…”
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Synergistic Activation of ERα by Estrogen and Prolactin in Breast Cancer Cells Requires Tyrosyl Phosphorylation of PAK1 by Oladimeji, Peter, Skerl, Rebekah, Rusch, Courtney, Diakonova, Maria

“…Serine/threonine kinase PAK1 is activated by estrogen and plays an important role in breast cancer. However, the integration of PAK1 into the estrogen response…”
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Three‐dimensional Collagen IV and Hormone Prolactin Regulate Breast Cancer Cell Invasion: Role of PAK1 and Matrix Metalloproteinases by Diakonova, Maria, Oladimeji, Peter, Rider, Leah

“…Abstract only Three‐dimensional (3D) matrix is a critical component of mammary tissue development not only under physiological but also in pathophysiological…”
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PAK1-Nck Regulates Cyclin D1 Promoter Activity in Response to Prolactin by Tao, Jing, Oladimeji, Peter, Rider, Leah, Diakonova, Maria

“…Prolactin (PRL) is critical for alveolar proliferation and differentiation in normal mammary development and is also implicated in breast cancer. PRL…”
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Phosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnover by Hammer, Alan, Oladimeji, Peter, De Las Casas, Luis E., Diakonova, Maria

“…The p21‐activated serine‐threonine kinase (PAK1) regulates cell motility and adhesion. We have previously shown that the prolactin (PRL)‐activated tyrosine…”
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