Pregnancy, Obstetric and Neonatal Outcomes in HIV Positive Nigerian Women

While the effect of HIV infection on some maternal outcomes is well established, for some others there is conflicting information on possible association with HIV. In this study we investigated pregnancy and neonatal outcome of HIV positive women in large HIV treatment centre over a period of 84 mon...

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Bibliographic Details
Published in:	African journal of reproductive health Vol. 17; no. 3; pp. 160 - 168
Main Authors:	Ezechi, OC, Gab-Okafor, CV, Oladele, DA, Kalejaiye, O.O, Oke, BO, Ohwodo, HO, Adu, RA, Ekama, SO, Musa, Z, Onwujekwe, DI, David, AN, Ujah, IAO
Format:	Journal Article
Language:	English
Published:	Nigeria Women's Health and Action Research Centre 01-09-2013 Women's Health and Action Research Centre (WHARC)
Subjects:	Adult adverse outcome AIDS-Related Opportunistic Infections - epidemiology Antiretroviral drugs CD4 Lymphocyte Count Complications and side effects delivery Female Health aspects Health care Health care delivery HIV HIV infection HIV infection in pregnancy HIV infections HIV patients HIV Seropositivity - ethnology Human immunodeficiency virus Humans Infant Mortality Infant, Low Birth Weight Infant, Newborn Low birth weight neonate Obstetrics Opportunistic infections Patient outcomes Perinatal death Pregnancy Pregnancy Complications, Infectious - ethnology Pregnancy outcome Pregnancy Outcome - ethnology Pregnant women Premature Birth Risk Factors Womens health Nigeria
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Summary:	While the effect of HIV infection on some maternal outcomes is well established, for some others there is conflicting information on possible association with HIV. In this study we investigated pregnancy and neonatal outcome of HIV positive women in large HIV treatment centre over a period of 84 months. They were managed according to the Nigerian PMTCT protocol. Adverse obstetric and neonatal outcome were observed in 48.3% HIV positives compared 30.3% to the negatives (OR: 2.08; CI: 1.84-2.34). Low birth weight ( OR:2.95; CI:1.95-3.1), preterm delivery (OR:2.05;CI:1.3-3.1), perinatal death (OR:1.9;CI:1.3-3.2), and spontaneous abortion (OR:1.37; CI:1.1-2.3) were factors found to be independently associated with HIV. Low CD4 count (OR: 2.45; CI: 1.34- 4.56) and opportunistic infections (OR: 2.11; CI: 1.56-3.45) were to be associated with adverse obstetric and neonatal outcome. This study confirms the association of HIV, severe immunosuppression and opportunistic infection and adverse obstetric and neonatal outcome. Alors que l'effet de l'infection par le VIH sur certains résultats maternels sont bien établis, pour certains d'autres, il ya des informations contradictoires sur l'association possible avec le VIH. Dans cette étude, nous avons étudié la grossesse et l'état néonatal des femmes séropositives dans un grand centre de traitement du VIH au cours d'une période de 84 mois. Elles étaient prises en charge selon le protocole nigérian de PTME. On a remarqué des résultats obstétricaux et néonatals Indésirables chez 48,3% des séropositives par rapport à 30,3% pour les négatifs (OR: 2,08, IC: 1,84 à 2,34). Le faible poids de naissance (OR: 2,95, IC : 1,95-3 ,1), l'accouchement prématuré (OR: 2,05, IC : 1,3-3 ,1), la mortalité périnatale (OR: 1,9, IC : 1,3-3 ,2), et l'avortement spontané (OR: 1,37 IC :1,1-2 3) étaient des facteurs qui seraient associés de façon indépendante avec le VIH. Les femmes qui ont un faible taux de CD4 (OR: 2,45, IC: 1,34 à 4,56) et les infections opportunistes (OR: 2,11, IC : 1,56-3 .45) devaient être associées aux résultats obstétricaux et néonatals défavorables. Cette étude confirme l'association entre le VIH, l'immunosuppression sévère et l'infection opportuniste, les résultats obstétricaux et néonatals défavorables.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1118-4841 2141-3606