Search Results - "Oladapo, Helen O."

Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies by Tarpley, Michael, Oladapo, Helen O., Strepay, Dillon, Caligan, Thomas B., Chdid, Lhoucine, Shehata, Hassan, Roques, Jose R., Thomas, Rhashad, Laudeman, Christopher P., Onyenwoke, Rob U., Darr, David B., Williams, Kevin P.

“…DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is highly expressed in glioma, an aggressive brain tumor, and has been proposed as a…”
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Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells by Oladapo, Helen O., Tarpley, Michael, Sauer, Scott J., Addo, Kezia A., Ingram, Shalonda M., Strepay, Dillon, Ehe, Ben K., Chdid, Lhoucine, Trinkler, Michael, Roques, Jose R., Darr, David B., Fleming, Jodie M., Devi, Gayathri R., Williams, Kevin P.

“…Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small…”
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Abstract C100: Identification and functional characterization of a novel GLI1 splice variant in breast cancer by Dixon, Maria S., Chdid, Lhoucine, Lamson, David R., Tarpley, Michael T., Oladapo, Helen O., Fleming, Jodie M., Freedman, Jennifer A., Devi, Gayathri R., Williams, Kevin P.

“…The purpose of this study is to investigate the biologic significance of novel GLI1 splice variants in breast cancer. African American (AA) women suffer a…”
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Abstract A138: Profiling of harmine and select analogs as differential inhibitors of DYRK1A and monoamine oxidase A: Exploring the potential for anti-cancer efficacy and minimizing off-target activity by Shehata, Hassan, Tarpley, Michael, Oladapo, Helen O, Strepay, Dillon, Roques, Jose R, Onyenwoke, Rob U, Darr, David B, Williams, Kevin P

“…DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) phosphorylates a number of substrates on serine/threonine residues, including tau,…”
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Identification of GLI Antagonists with Efficacy in Locally Advanced Breast Cancers by Oladapo, Helen O

“…The Hedgehog (Hh) pathway is an important pathway that is involved in the embryonic development of organs and the regulation of cell differentiation,…”
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