Search Results - "Olğar, Yusuf"

Tetrodotoxin-Sensitive Neuronal-Type Na + Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation by Munger, Mark A, Olğar, Yusuf, Koleske, Megan L, Struckman, Heather L, Mandrioli, Jessica, Lou, Qing, Bonila, Ingrid, Kim, Kibum, Ramos Mondragon, Roberto, Priori, Silvia G, Volpe, Pompeo, Valdivia, Héctor H, Biskupiak, Joseph, Carnes, Cynthia A, Veeraraghavan, Rengasayee, Györke, Sándor, Radwański, Przemysław B

“…Background Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca…”
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A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats by Durak, Aysegul, Olgar, Yusuf, Degirmenci, Sinan, Akkus, Erman, Tuncay, Erkan, Turan, Belma

“…Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in…”
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Mitochondria-Targeting Antioxidant Provides Cardioprotection through Regulation of Cytosolic and Mitochondrial Zn2+ Levels with Re-Distribution of Zn2+-Transporters in Aged Rat Cardiomyocytes by Olgar, Yusuf, Tuncay, Erkan, Turan, Belma

“…Aging is an important risk factor for cardiac dysfunction. Heart during aging exhibits a depressed mechanical activity, at least, through…”
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Bimodal Effects of P2Y12 Antagonism on Matrix Metalloproteinase–Associated Contractile Dysfunction in İnsulin-Resistant Mammalian Heart by Olgar, Yusuf, Tuncay, Erkan, Billur, Deniz, Turan, Belma

“…The matrix metalloproteinases (MMPs) contribute to matrix remodeling in diabetes via tissue degradation; however, their contributions can be different…”
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Ticagrelor alleviates high-carbohydrate intake induced altered electrical activity of ventricular cardiomyocytes by regulating sarcoplasmic reticulum–mitochondria miscommunication by Olgar, Yusuf, Durak, Aysegul, Degirmenci, Sinan, Tuncay, Erkan, Billur, Deniz, Ozdemir, Semir, Turan, Belma

“…Metabolic syndrome (MetS) is associated with additional cardiovascular risk in mammalians while there are relationships between hyperglycemia-associated…”
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Ticagrelor reverses the mitochondrial dysfunction through preventing accumulated autophagosomes-dependent apoptosis and ER stress in insulin-resistant H9c2 myocytes by Olgar, Yusuf, Tuncay, Erkan, Billur, Deniz, Durak, Aysegul, Ozdemir, Semir, Turan, Belma

“…Ticagrelor, a P 2 Y 12 -receptor inhibitor, and a non-thienopyridine agent are used to treat diabetic patients via its effects on off-target mechanisms…”
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Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance by Olgar, Yusuf, Degirmenci, Sinan, Durak, Aysegul, Billur, Deniz, Can, Belgin, Kayki-Mutlu, Gizem, Arioglu-Inan E, Ebru, Turan, Belma

“…Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key…”
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Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity by Alyu, Feyza, Olgar, Yusuf, Degirmenci, Sinan, Turan, Belma, Ozturk, Yusuf

“…Consumption of illicit pharmaceutical products containing sibutramine has been reported to cause cardiovascular toxicity problems. This study aimed to…”
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NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling by Tarasov, Mikhail, Struckman, Heather L, Olgar, Yusuf, Miller, Alec, Demirtas, Mustafa, Bogdanov, Vladimir, Terentyeva, Radmila, Soltisz, Andrew M, Meng, Xiaolei, Min, Dennison, Sakuta, Galina, Dunlap, Izabella, Duran, Antonia D, Foster, Mark P, Davis, Jonathan P, Terentyev, Dmitry, Györke, Sándor, Veeraraghavan, Rengasayee, Radwański, Przemysław B

“…Calmodulin (CaM) plays critical roles in cardiomyocytes, regulating Na+ (NaV) and L-type Ca2+ channels (LTCCs). LTCC dysregulation by mutant CaMs has been…”
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Olive oil attenuates oxidative damage by improving mitochondrial functions in human keratinocytes by Yazihan, Nuray, Akdas, Sevginur, Olgar, Yusuf, Biriken, Derya, Turan, Belma, Ozkaya, MucahitTaha

“…[Display omitted] •HP-EVOO application on HaCaT cells might improve the defensive system by increasing the antioxidant capacity.•HP-EVOO helps HaCaT cells to…”
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STIM1-Orai1 interaction mediated calcium influx activation contributes to cardiac contractility of insulin-resistant rats by Durak, Aysegul, Olgar, Yusuf, Genc, Kardelen, Tuncay, Erkan, Akat, Fırat, Degirmenci, Sinan, Turan, Belma

“…Metabolic syndrome (MetS) became a tremendous public health burden in the last decades. Store-operated calcium entry (SOCE) is a unique mechanism that causes a…”
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Increased free Zn2+ correlates induction of sarco(endo)plasmic reticulum stress via altered expression levels of Zn2+‐transporters in heart failure by Olgar, Yusuf, Durak, Aysegul, Tuncay, Erkan, Bitirim, Ceylan Verda, Ozcinar, Evren, Inan, Mustafa Bahadir, Tokcaer‐Keskin, Zeynep, Akcali, Kamil Can, Akar, Ahmet Ruchan, Turan, Belma

“…Zn2+‐homoeostasis including free Zn2+ ([Zn2+]i) is regulated through Zn2+‐transporters and their comprehensive understanding may be important due to their…”
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Trace elements in diabetic cardiomyopathy:An electrophysiological overview by Ozturk, Nihal, Olgar, Yusuf, Ozdemir, Semir

“…There is a growing body of evidence that Diabetes Mellitus leads to a specific cardiomyopathy apart from vascular disease and bring about high morbidity and…”
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Yaşa bağlı kalp fonksiyon değişiklikleri ve miRNA’lar by Olğar,Yusuf, Billur,Deniz, Turan,Belma

“…Amaç: Kalp fonksiyonundaki değişimler ile gen ifadelerindeki değişimler arasında yakın ilişkiler olduğu ve özellikle gen ifadesi sonrası modifikasyonların bu…”
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Intracellular Redistribution of Left Ventricular Connexin 43 Contributes to the Remodeling of Electrical Properties of the Heart in Insulin-resistant Elderly Rats by Billur, Deniz, Olgar, Yusuf, Turan, Belma

“…The correlation between long-QT and connexin 43 (Cx43) status and localization in elderly rats was determined to demonstrate a correlation between insulin…”
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Estrogen induces the regenerative capacity of Sca1+ cardiac progenitor cells by Genc, Kardelen, Olgar, Yusuf, Bitirim, Ceylan Verda

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Anorektik ajan sibutraminin metabolik sendromlu sıçan ventrikül hücrelerinin elektriksel aktivitesine toksik etkilerinin konsantrasyona bağlı incelenmesi by Olğar,Yusuf, Alyu,Feyza, Öztürk,Yusuf, Turan,Belma

“…Amaç: Son yıllarda kısa sürede kilo kaybetmek için kullanılan sibutraminin (SBT) sistemik etki mekanizmaları arasında kahverengi yağ dokusu termogenezi,…”
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MitoTEMPO provides an antiarrhythmic effect in aged-rats through attenuation of mitochondrial reactive oxygen species by Olgar, Yusuf, Billur, Deniz, Tuncay, Erkan, Turan, Belma

“…The death prevalence from cardiovascular disease is significantly high in elderly-populations, while mitochondrial-aging plays an important in abnormal…”
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Induction of endoplasmic reticulum stress and changes in expression levels of Zn2+-transporters in hypertrophic rat heart by Olgar, Yusuf, Ozdemir, Semir, Turan, Belma

“…Clinical and experimental studies have shown an association between intracellular free Zn 2+ ([Zn 2+ ] i )-dyshomeostasis and cardiac dysfunction besides [Ca…”
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Comparisons of pleiotropic effects of SGLT2 inhibition and GLP-1 agonism on cardiac glucose intolerance in heart dysfunction by Turan, Belma, Durak, Aysegul, Olgar, Yusuf, Tuncay, Erkan

“…Recent studies discuss the evidence of lesser degrees of hyperglycemia contribution to cardiovascular disease (CVD) than impaired glucose tolerance. Indeed,…”
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