Search Results - "Okyar, Alper"

Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy by Dallmann, Robert, Okyar, Alper, Lévi, Francis

“…Abstract Daily rhythms in physiology significantly modulate drug pharmacokinetics and pharmacodynamics according to the time-of-day, a finding that has led to…”
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Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy by Ozturk, Narin, Ozturk, Dilek, Kavakli, Ibrahim Halil, Okyar, Alper

“…The circadian timing system (CTS) controls various biological functions in mammals including xenobiotic metabolism and detoxification, immune functions, cell…”
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Reproductive effects of subchronic exposure to acetamiprid in male rats by Arıcan, Emre Yağmur, Gökçeoğlu Kayalı, Damla, Ulus Karaca, Bahar, Boran, Tuğçe, Öztürk, Narin, Okyar, Alper, Ercan, Feriha, Özhan, Gül

“…Acetamiprid, a selective agonist of nicotinic acetylcholine recetors, is one of the most widely used neonicotinoids. There is limited data about toxicity of…”
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Identification of Circadian Determinants of Cancer Chronotherapy through In Vitro Chronopharmacology and Mathematical Modeling by Dulong, Sandrine, Ballesta, Annabelle, Okyar, Alper, Lévi, Francis

“…Cancer chronotherapy aims at enhancing tolerability and efficacy of anticancer drugs through their delivery according to circadian clocks. However, mouse and…”
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Circadian Timing in Cancer Treatments by LEVI, Francis, OKYAR, Alper, DULONG, Sandrine, INNOMINATO, Pasquale F, CLAIRAMBAULT, Jean

“…The circadian timing system is composed of molecular clocks, which drive 24-h changes in xenobiotic metabolism and detoxification, cell cycle events, DNA…”
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A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude by Doruk, Yagmur Umay, Yarparvar, Darya, Akyel, Yasemin Kubra, Gul, Seref, Taskin, Ali Cihan, Yilmaz, Fatma, Baris, Ibrahim, Ozturk, Nuri, Türkay, Metin, Ozturk, Narin, Okyar, Alper, Kavakli, Ibrahim Halil

“…Proper function of many physiological processes requires a robust circadian clock. Disruptions of the circadian clock can result in metabolic diseases, mood…”
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Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling by Okyar, Alper, Kumar, Swati A., Filipski, Elisabeth, Piccolo, Enza, Ozturk, Narin, Xandri-Monje, Helena, Pala, Zeliha, Abraham, Kristin, Gomes, Ana Rita Gato de Jesus, Orman, Mehmet N., Li, Xiao-Mei, Dallmann, Robert, Lévi, Francis, Ballesta, Annabelle

“…P-glycoprotein ( P-gp ) largely influences the pharmacokinetics (PK) and toxicities of xenobiotics in a patient-specific manner so that personalized drug…”
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Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice by Gul, Seref, Akyel, Yasemin Kubra, Gul, Zeynep Melis, Isin, Safak, Ozcan, Onur, Korkmaz, Tuba, Selvi, Saba, Danis, Ibrahim, Ipek, Ozgecan Savlug, Aygenli, Fatih, Taskin, Ali Cihan, Akarlar, Büşra Aytül, Ozlu, Nurhan, Ozturk, Nuri, Ozturk, Narin, Ünal, Durişehvar Özer, Guzel, Mustafa, Turkay, Metin, Okyar, Alper, Kavakli, Ibrahim Halil

“…Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals…”
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Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice by Akyel, Yasemin Kubra, Ozturk Civelek, Dilek, Ozturk Seyhan, Narin, Gul, Seref, Gazioglu, Isil, Pala Kara, Zeliha, Lévi, Francis, Kavakli, Ibrahim Halil, Okyar, Alper

“…The circadian timing system controls absorption, distribution, metabolism, and elimination processes of drug pharmacokinetics over a 24-h period. Exposure of…”
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Therapeutic Effect of C-Vx Substance in K18-hACE2 Transgenic Mice Infected with SARS-CoV-2 by Ulbegi Polat, Hivda, Abaci, Irem, Tas Ekiz, Arzu, Aksoy, Ozge, Oktelik, Fatma Betul, Yilmaz, Vuslat, Tekin, Saban, Okyar, Alper, Oncul, Oral, Deniz, Gunnur

“…C-Vx is a bioprotective product designed to boost the immune system. This study aimed to determine the antiviral activity of the C-Vx substance against…”
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Circadian Dysfunction in Adipose Tissue: Chronotherapy in Metabolic Diseases by Civelek, Erkan, Ozturk Civelek, Dilek, Akyel, Yasemin Kubra, Kaleli Durman, Deniz, Okyar, Alper

“…Essential for survival and reproduction, the circadian timing system (CTS) regulates adaptation to cyclical changes such as the light/dark cycle, temperature…”
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A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery by Ballesta, Annabelle, Dulong, Sandrine, Abbara, Chadi, Cohen, Boris, Okyar, Alper, Clairambault, Jean, Levi, Francis

“…Circadian timing largely modifies efficacy and toxicity of many anticancer drugs. Recent findings suggest that optimal circadian delivery patterns depend on…”
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Toxic effects of subchronic oral acetamiprid exposure in rats by Karaca, Bahar Ulus, Arican, Yağmur Emre, Boran, Tugce, Binay, Sevgi, Okyar, Alper, Kaptan, Engin, Özhan, Gül

“…Acetamiprid, a selective agonist of type-2 nicotinic acetylcholine receptors, is one of the most widely used neonicotinoids. The hepato- and nephrotoxic…”
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Gliclazide alone or in combination with atorvastatin ameliorated reproductive damage in streptozotocin-induced type 2 diabetic male rats by Öztaş, Ezgi, Yılmaz, Tugba Ekiz, Güzel, Elif, Sezer, Zehra, Okyar, Alper, Özhan, Gül

“…[Display omitted] •High-fat diet/STZ-induced T2DM caused severe damage in rat male reproductive system.•ATV treatment slightly improved the reproductive…”
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Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study by Pilancı, Kezban Nur, Saglam, Sezer, Okyar, Alper, Yucel, Serap, Pala-Kara, Zeliha, Ordu, Cetin, Namal, Esat, Ciftci, Rumeysa, Iner-Koksal, Ulkuhan, Kaytan-Saglam, Esra

“…Purpose The aim of this study was to evaluate safety and toxicity of chronomodulated capecitabine administered in the morning and at noon according to a…”
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Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum by Okyar, Alper, Piccolo, Enza, Ahowesso, Constance, Filipski, Elisabeth, Hossard, Virginie, Guettier, Catherine, La Sorda, Rosanna, Tinari, Nicola, Iacobelli, Stefano, Lévi, Francis

“…ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed…”
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Circadian variations in exsorptive transport: in situ intestinal perfusion data and in vivo relevance by Okyar, Alper, Dressler, Cornelia, Hanafy, Abeer, Baktir, Gül, Lemmer, Björn, Spahn-Langguth, Hilde

“…The circadian timing system (CTS) governs the 24-h rhythm of the organism and, hence, also main pathways responsible for drug pharmacokinetics. P-glycoprotein…”
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Effect of Aloe vera Leaf Gel and Pulp Extracts on the Liver in Type-II Diabetic Rat Models by Can, Ayse, Akev, Nuriye, Ozsoy, Nurten, Bolkent, Sehnaz, Arda, Bahriye Pelin, Yanardag, Refiye, Okyar, Alper

“…The aim of this work was to investigate the effects of Aloe vera leaf pulp and gel extracts on the liver tissue of neonatal streptozotocin (n0STZ)-induced…”
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Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models by Okyar, Alper, Can, Ayşe, Akev, Nuriye, Baktir, Gül, Sütlüpinar, Nurhayat

“…Aloe vera (L.) Burm. fil. (= A. barbadensis Miller) (Liliaceae) is native to North Africa and also cultivated in Turkey. Aloes have long been used all over the…”
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Evaluation of the association of SNP in carboxylesterase enzyme (CES1) with pharmacokinetic and adverse effects of capecitabine in breast and colorectal cancer patients by Kurtan Yüksel,Merve, Öztürk,Dilek, Öztaş,Ezgi, Özhan,Gül, Altanlar Türker,Aylin, Korkmaz,Taner, Okyar,Alper, Pala Kara,Zeliha

“…Capecitabine is an oral prodrug and converted to 5-fluorouracil using three-step enzymatic pathways which include carboxylesterase (CES). Interindividual…”
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