Search Results - "Okuno, Shiro"

MUTATED G-PROTEIN-COUPLED RECEPTOR GPR10 IS RESPONSIBLE FOR THE HYPERPHAGIA/DYSLIPIDAEMIA/OBESITY LOCUS OF Dmo1 IN THE OLETF RAT by Watanabe, Takeshi K, Suzuki, Mikio, Yamasaki, Yuki, Okuno, Shiro, Hishigaki, Haretsugu, Ono, Toshihide, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Tsuji, Atsushi, Kanemoto, Naohide, Wakitani, Shigeyuki, Takagi, Toshihisa, Nakamura, Yusuke, Tanigami, Akira

“…SUMMARY 1. We have confirmed the Diabetes Mellitus OLETF type I (Dmo1) effect on hyperphagia, dyslipidaemia and obesity in the Otsuka Long‐Evans Tokushima…”
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Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus by Kanemoto, N, Hishigaki, H, Miyakita, A, Oga, K, Okuno, S, Tsuji, A, Takagi, T, Takahashi, E, Nakamura, Y, Watanabe, T K

“…To elucidate the genetic factors underlying non-insulin-dependent diabetes mellitus (NIDDM), we performed genome-wide quantitative trait locus (QTL) analysis,…”
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Cloning and chromosomal mapping of a novel ABC transporter gene ( ), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia by Shimada, Y, Okuno, S, Kawai, A, Shinomiya, H, Saito, A, Suzuki, M, Omori, Y, Nishino, N, Kanemoto, N, Fujiwara, T, Horie, M, Takahashi, E

“…We isolated a novel human ATP-binding cassette (ABC) transporter cDNA, determined its nucleotide sequence, and designated it human ABC7 (hABC7). The nucleotide…”
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Relationship between mutations in the DNA gyrase and topoisomerase IV genes and nadifloxacin resistance in clinically isolated quinolone-resistant Staphylococcus aureus by OIZUMI, Nobuyuki, KAWABATA, Shigekatsu, HIRAO, Maasa, WATANABE, Kozo, OKUNO, Shiro, FUJIWARA, Tsutomu, KIKUCHI, Mikio

“…We analyzed the relationship between resistance to nadifloxacin, a fluoroquinolone antimicrobial agent, and mutations in the quinolone resistance-determining…”
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Single-Allele Correction Of The Dmo1 Locus In Congenic Animals Substantially Attenuates Obesity, Dyslipidaemia And Diabetes Phenotypes Of The Oletf Rat by Watanabe, Takeshi K, Okuno, Shiro, Ono, Toshihide, Yamasaki, Yuki, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Miyao, Hideo, Suzuki, Mikio, Momota, Hiroshi, Goto, Yoshihiro, Shinomiya, Hiroichi, Hishigaki, Haretsugu, Hayashi, Isamu, Asai, Toshihiro, Wakitani, Shigeyuki, Takagi, Toshihisa, Nakamura, Yusuke, Tanigami, Akira

“…SUMMARY 1. Whole‐genome scans have identified Dmo1 as a major quantitative trait locus for dyslipidaemia and obesity in the Otsuka Long Evans Tokushima Fatty…”
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Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene by Kanemoto, Naohide, Kondo, Mari, Iwanaga, Tomoyuki, Hishigaki, Haretsugu, Ono, Toshihide, Mizoguchi-Miyakita, Ayako, Oga, Keiko, Tsuji, Atsushi, Okuno, Shiro, Watanabe, Takeshi K., Nose, Masato, Tanigami, Akira

“…An Otsuka Long–Evans Tokushima Fatty (OLETF) strain of rat spontaneously developed hyperglycemia, hyperinsulinemia, insulin resistance and mild obesity, which…”
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Genetic Dissection of “OLETF,” a Rat Model for Non-Insulin-Dependent Diabetes Mellitus: Quantitative Trait Locus Analysis of (OLETF × BN) × OLETF by Watanabe, Takeshi K., Okuno, Shiro, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Tsuji, Atsushi, Yamasaki, Yuki, Hishigaki, Haretsugu, Kanemoto, Naohide, Takagi, Toshihisa, Takahashi, Ei-ichi, Irie, Yasuo, Nakamura, Yusuke, Tanigami, Akira

“…To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci…”
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A radiation hybrid map of the rat genome containing 5,255 markers by Yamasaki, Yuki, Watanabe, Takeshi K, Kanemoto, Naohide, Oga, Keiko, Irie, Yasuo, Browne, Julie, Adachi, Masakazu, Kiguwa, Susanna L, James, Michael R, Critcher, Ricky, Hayashi, Hiromi, Lathrop, G. Mark, Knights, Catherine, Webber, Caleb, Ono, Toshihide, Davis, Marie, Nakamura, Yusuke, Tanigami, Akira, Thangarajah, Thiru, Goodfellow, Peter N, Tsuji, Atsushi, Takahashi, Ei-ichi, Mizoguchi-Miyakita, Ayako, Kiel, Susanne, Hishigaki, Haretsugu, Day, Philip J.R, Miller, Jonathan, Smith, Angela, Tomita, Kazuhiro, Hudson, James R, McCarthy, Linda C, Bihoreau, Marie-Therese, Takagi, Toshihisa, Okuno, Shiro

“…A whole-genome radiation hybrid (RH) panel was used to construct a high-resolution map of the rat genome based on microsatellite and gene markers. These…”
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Dual-Band Transmitarray Consisting of Unit Cells with Asterisk and Cross Dipole Elements Separated by Ring Elements by Okuno, Shiro, Shimizu, Syota, Deguchi, Hiroyuki, Tsuji, Mikio

“…This paper describes a dual-band transmitarray using asterisk resonators and a cross-shaped resonator as unit elements. Then, addition of ring elements reduces…”
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Altered emotional behaviors in the diabetes mellitus OLETF type 1 congenic rat by Watanabe, Akihito, Okuno, Shiro, Okano, Mai, Jordan, Shaun, Aihara, Koutoku, Watanabe, Takeshi K, Yamasaki, Yuki, Kitagawa, Hisashi, Sugawara, Kiyoshi, Kato, Satoru

“…Abstract GPR10 is a G-protein-coupled receptor expressed in thalamic and hypothalamic brain regions, including the reticular thalamic nucleus (RTN) and…”
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Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain by Okuno, S, Watanabe, T K, Ono, T, Oga, K, Mizoguchi-Miyakita, A, Yamasaki, Y, Goto, Y, Shinomiya, H, Momota, H, Miyao, H, Hayashi, I, Asai, T, Suzuki, M, Harada, Y, Hishigaki, H, Wakitani, S, Takagi, T, Nakamura, Y, Tanigami, A

“…Whole-genome scans have identified Dmo1 as a major quantitative trait locus (QTL) for obesity and dyslipidaemia in the Otsuka Long Evans Tokushima Fatty…”
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Genetic dissection of OLETF, a rat model for non-insulin-dependent diabetes mellitus : Quantitative trait locus analysis of (OLETF x BN) x OLETF by WATANABE, T. K, OKUNO, S, IRIE, Y, NAKAMURA, Y, TANIGAMI, A, OGA, K, MIZOGUCHI-MIYAKITA, A, TSUJI, A, YAMASAKI, Y, HISHIGAKI, H, KANEMOTO, N, TAKAGI, T, TAKAHASHI, E.-I

“…To identify genetic determinants relevant to non-insulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trait loci…”
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A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats by Watanabe, Takeshi K, Okuno, Shiro, Yamasaki, Yuki, Ono, Toshihide, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Miyao, Hideo, Suzuki, Mikio, Momota, Hiroshi, Goto, Yoshihiro, Shinomiya, Hiroichi, Hishigaki, Haretsugu, Hayashi, Isamu, Asai, Toshihiro, Wakitani, Shigeyuki, Takagi, Toshihisa, Nakamura, Yusuke, Tanigami, Akira

“…Summary 1. Dmo1 (Diabetes Mellitus OLETF type I) is a major quantitative trait locus for dyslipidaemia, obesity and diabetes phenotypes of male Otsuka Long…”
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Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families by Kawai, Hisaomi, Akaike, Masashi, Kunishige, Makoto, Inui, Toshio, Adachi, Katsuhito, Kimura, Chiyomi, Kawajiri, Masakazu, Nishida, Yoshihiko, Endo, Itsuro, Kashiwagi, Setsuko, Nishino, Hiroshi, Fujiwara, Tsutomu, Okuno, Shiro, Roudaut, Carinne, Richard, Isabelle, Beckmann, Jacques S., Miyoshi, Kazuo, Matsumoto, Toshio

“…We report on the clinical, pathological, and genetic features of 7 patients with limb‐girdle muscular dystrophy type 2A (LGMD2A) from three Japanese families…”
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Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats by Okuno, S, Watanabe, T K, Ono, T, Yamasaki, Y, Goto, Y, Miyao, H, Asai, T, Kanemoto, N, Oga, K, Mizoguchi-Miyakita, A, Takagi, T, Takahashi, E, Nakamura, Y, Tanigami, A

“…Altered lipid metabolism is closely associated with diabetes in humans, although predisposing genetic factors that affect hyperlipidemia have not yet been…”
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Adhalin gene mutations in patients with autosomal recessive childhood onset muscular dystrophy with adhalin deficiency by Kawai, H, Akaike, M, Endo, T, Adachi, K, Inui, T, Mitsui, T, Kashiwagi, S, Fujiwara, T, Okuno, S, Shin, S

“…Homozygous adhalin gene mutations were found in three patients from two consanguineous families with autosomal recessive childhood onset muscular dystrophy…”
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Confirmation of a Major QTL, Dmo1, Linked to Obesity, Dyslipidemia and Hyperglycemia in the Otsuka Long Evans Tokushima Fatty by SUZUKI, MIKIO, WATANABE, TAKESHI K, OKUNO, SHIRO, YAMASAKI, YUKI, ONO, TOSHIHIDE, OGA, KEIKO, MIZOGUCHI-MIYAKITA, AYAKO, MIYAO, HIDEO, MOMOTA, HIROSHI, GOTO, YOSHIHIRO, SHINOMIYA, HIROICHI, HAYASHI, ISAMU, ASAI, TOSHIHIRO, TANIGAMI, AKIRA

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Characterization of newly developed SSLP markers for the rat by Watanabe, T K, Ono, T, Okuno, S, Mizoguchi-Miyakita, A, Yamasaki, Y, Kanemoto, N, Hishigaki, H, Oga, K, Takahashi, E, Irie, Y, Bihoreau, M T, James, M R, Lathrop, G M, Takagi, T, Nakamura, Y, Tanigami, A

“…We have isolated more than 12,000 clones containing microsatellite sequences, mainly consisting of (CA)n dinucleotide repeats, using genomic DNA from the BN…”
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Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats by Yamasaki, Y, Watanabe, T K, Okuno, S, Ono, T, Oga, K, Mizoguchi-Miyakita, A, Goto, Y, Shinomiya, H, Momota, H, Miyao, H, Hayashi, I, Asai, T, Suzuki, M, Harada, Y, Hishigaki, H, Wakitani, S, Takagi, T, Nakamura, Y, Tanigami, A

“…1. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a model of type II diabetes with accompanying dyslipidaemia and obesity. 2. To define chromosomal…”
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Quantitative Trait Loci For Lipid Metabolism In The Study Of Oletf × (Oletf × Fischer 344) Backcross Rats by Yamasaki, Yuki, Watanabe, Takeshi K, Okuno, Shiro, Ono, Toshihide, Oga, Keiko, Mizoguchi-Miyakita, Ayako, Goto, Yoshihiro, Shinomiya, Hiroichi, Momota, Hiroshi, Miyao, Hideo, Hayashi, Isamu, Asai, Toshihiro, Suzuki, Mikio, Harada, Yosuke, Hishigaki, Haretsugu, Wakitani, Shigeyuki, Takagi, Toshihisa, Nakamura, Yusuke, Tanigami, Akira

“…SUMMARY 1. The Otsuka Long‐Evans Tokushima Fatty (OLETF) rat is a model of type II diabetes with accompanying dyslipidaemia and obesity. 2. To define…”
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