The Effect of β-Hydroxy-β-Methylbutyrate (HMB) on Sarcopenia and Functional Frailty in Older Persons: A Systematic Review

Background Beta-hydroxy-beta-methylbutyrate (HMB) has been shown to be effective and superior to other types of protein supplements to attenuate loss of muscle mass, strength and function, however, its benefits in sarcopenic and frail older people remain unclear. Objective We seek to determine the e...

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Bibliographic Details
Published in:	The Journal of nutrition, health & aging Vol. 23; no. 2; pp. 145 - 150
Main Authors:	Oktaviana, J., Zanker, J., Vogrin, S., Duque, Gustavo
Format:	Journal Article
Language:	English
Published:	Paris Springer Paris 01-02-2019 Springer Nature B.V
Subjects:	Aged Aged, 80 and over Aging Body Composition Clinical trials Dietary Supplements Evidence-based medicine Female Frailty Frailty - drug therapy Geriatrics/Gerontology Hand Strength - physiology Humans Male Medicine Medicine & Public Health Muscle, Skeletal - physiology Muscular system Neurosciences Nutrition Older people Primary Care Medicine Proteins Quality of Life Research Randomized Controlled Trials as Topic Sarcopenia Sarcopenia - drug therapy Sarcopenia - physiopathology Systematic review Valerates - therapeutic use frailty Beta-hydroxy-beta-methylbutyrate HMB muscle sarcopenia
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Summary:	Background Beta-hydroxy-beta-methylbutyrate (HMB) has been shown to be effective and superior to other types of protein supplements to attenuate loss of muscle mass, strength and function, however, its benefits in sarcopenic and frail older people remain unclear. Objective We seek to determine the effect of HMB on muscle mass, strength and function in older people with sarcopenia or frailty by reviewing results from available randomized controlled trials (RCTs). Design This review was registered at PROSPERO (University of York) with registration number CRD42018088462 and conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Using a pre-determined e-search strategy, we searched PubMed, Medline, EMBASE, CINAHL, LILACS, Web of Science, Cochrane and Scopus databases. Our inclusion criteria were RCTs that assessed the effect of HMB on muscle mass, strength and function in older people with sarcopenia and frailty aged ≥60 years. The main outcomes were lean body mass, handgrip, leg press strength, and Short Physical Performance Battery (SPPB) score. Results Three studies matched our eligibility criteria which enrolled 203 subjects through a variety of definitions of sarcopenia or frailty. Lean body mass increased and muscle strength and function were preserved following HMB supplementation. Conclusion HMB improves lean muscle mass and preserves muscle strength and function in older people with sarcopenia or frailty.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1279-7707 1760-4788
DOI:	10.1007/s12603-018-1153-y