Search Results - "Okpechi, Samuel C"

Ceritinib is a novel triple negative breast cancer therapeutic agent by Dong, Shengli, Yousefi, Hassan, Savage, Isabella Van, Okpechi, Samuel C, Wright, Maryl K, Matossian, Margarite D, Collins-Burow, Bridgette M, Burow, Matthew E, Alahari, Suresh K

“…Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of…”
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Clinical Effects of Cigarette Smoking: Epidemiologic Impact and Review of Pharmacotherapy Options by Onor, IfeanyiChukwu O, Stirling, Daniel L, Williams, Shandrika R, Bediako, Daniel, Borghol, Amne, Harris, Martha B, Darensburg, Tiernisha B, Clay, Sharde D, Okpechi, Samuel C, Sarpong, Daniel F

“…Cigarette smoking-a crucial modifiable risk factor for organ system diseases and cancer-remains prevalent in the United States and globally. In this literature…”
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Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH Δ5-6 Knockout Mouse Model by Nguyen, Tina H, Yousefi, Hassan, Okpechi, Samuel C, Lauterboeck, Lothar, Dong, Shengli, Yang, Qinglin, Alahari, Suresh K

“…Nischarin (Nisch) is a cytosolic scaffolding protein that harbors tumor-suppressor-like characteristics. Previous studies have shown that Nisch functions as a…”
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Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action by Yousefi, Hassan, Mashouri, Ladan, Okpechi, Samuel C., Alahari, Nikhilesh, Alahari, Suresh K.

“…[Display omitted] The outbreak of a novel coronavirus (SARS-CoV-2) has caused a major public health concern across the globe. SARS-CoV-2 is the seventh…”
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Association of Serum Magnesium with Blood Pressure in Patients with Hypertensive Crises: A Retrospective Cross-Sectional Study by Onor, IfeanyiChukwu O, Hill, Lashira M, Famodimu, Modupe M, Coleman, Mallory R, Huynh, Carolkim H, Beyl, Robbie A, Payne, Casey J, Johnston, Emily K, Okogbaa, John I, Gillard, Christopher J, Sarpong, Daniel F, Borghol, Amne, Okpechi, Samuel C, Norbert, Ifeyinwa, Sanne, Shane E, Guillory, Shane G

“…The role of magnesium in blood pressure has been studied among hypertensive patients; however, there is a dearth of studies exploring the role of magnesium in…”
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A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming by Yousefi, Hassan, Khosla, Maninder, Lauterboeck, Lothar, Okpechi, Samuel C., Worthylake, David, Garai, Jone, Zabaleta, Jovanny, Guidry, Jessie, Zarandi, Mohammad Amin, Wyczechowska, Dorota, Jayawickramarajah, Janarthanan, Yang, Qinglin, Kissil, Joseph, Alahari, Suresh K.

“…Treatment of patients with triple-negative breast cancer (TNBC) has been challenging due to the absence of well-defined molecular targets and the highly…”
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Role of Nischarin in the pathology of diseases: a special emphasis on breast cancer by Okpechi, Samuel C., Yousefi, Hassan, Nguyen, Khoa, Cheng, Thomas, Alahari, Nikhilesh V., Collins-Burow, Bridgette, Burow, Matthew E., Alahari, Suresh K.

“…Nischarin has been demonstrated to have tumor suppressor functions. In this review, we comprehensively discuss up to date information about Nischarin. In…”
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Correction to: A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming by Yousefi, Hassan, Khosla, Maninder, Lauterboeck, Lothar, Okpechi, Samuel C., Worthylake, David, Garai, Jone, Zabaleta, Jovanny, Guidry, Jessie, Zarandi, Mohammad Amin, Wyczechowska, Dorota, Jayawickramarajah, Janarthanan, Yang, Qinglin, Kissil, Joseph, Alahari, Suresh K.

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Small Molecule Anticancer Compound Modulates Cell Cycle DNA Damage Response Pathway and Inhibit Tumorigenesis in Triple Negative Breast Cancer by Okpechi, Samuel C., Dong, Shengli, Yousefi, Hassan, Guidry, Jessie J., Otohinoyi, David A., Worthylake, David K., Hicks, Chindo, Alahari, Suresh K.

“…Objective To investigate the mechanism of action and therapeutic benefits of NSC001, a small molecule anticancer compound, in the treatment of triple negative…”
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Acute effect of inhaled iloprost on exercise dynamic hyperinflation in COPD patients: A randomized crossover study by Lammi, Matthew R., Ghonim, Mohamed A., Johnson, Jessica, D'Aquin, Johnny, Zamjahn, John B., Pellett, Andy, Okpechi, Samuel C., Romaine, Connie, Pyakurel, Kusma, Luu, Hahn H., Shellito, Judd E., Boulares, A. Hamid, deBoisblanc, Bennett P.

“…We tested whether the prostacyclin analog inhaled iloprost modulates dead space, dynamic hyperinflation (DH), and systemic inflammation/oxidative stress during…”
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Global Sex Disparity of COVID-19: A Descriptive Review of Sex Hormones and Consideration for the Potential Therapeutic Use of Hormone Replacement Therapy in Older Adults by Okpechi, Samuel C, Fong, Jordyn T, Gill, Shawn S, Harman, Jarrod C, Nguyen, Tina H, Chukwurah, Queendaleen C, Onor, IfeanyiChukwu O, Alahari, Suresh K

“…The 2019-2020 SARS-related coronavirus-2 (SARS-CoV-2) pandemic has brought unprecedented challenges to healthcare sectors around the world. As of November…”
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Glycemic control in diabetic patients improved overall lung cancer survival across diverse populations by Wu, Wayne Y, Luke, Brian, Wu, Xiao-Cheng, Lee, J Jack, Yi, Yong, Okpechi, Samuel C, Gause, Barry, Mehta, Paras, Sherman, Steven I, Ochoa, Augusto, Dmitrovsky, Ethan, Liu, Xi

“…The consequence of diabetes on lung cancer overall survival (OS) is debated. This retrospective study used 2 large lung cancer databases to assess…”
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Microparticles in systemic sclerosis: Potential pro‐inflammatory mediators and pulmonary hypertension biomarkers by Lammi, Matthew R., Saketkoo, Lesley Ann, Okpechi, Samuel C., Ghonim, Mohamed A., Wyczechowska, Dorota, Bauer, Natalie, Pyakurel, Kusma, Saito, Saito, deBoisblanc, Bennett P., Boulares, A. Hamid

“…ABSTRACT Background and objective Endothelial microparticles (EMP) are submicron vesicles released from endothelial cells. We aimed to determine the utility of…”
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Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD by Lammi, Matthew R, Ghonim, Mohamed A, Pyakurel, Kusma, Naura, Amarjit S, Ibba, Salome V, Davis, Christian J, Okpechi, Samuel C, Happel, Kyle I, deBoisblanc, Bennett P, Shellito, Judd, Boulares, A Hamid

“…Pulmonary endothelial prostacyclin appears to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). The effect of treatment with a…”
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Pioglitazone’s beneficial effects on erectile function preservation after cavernosal nerve injury in the rat are negated by inhibition of the insulin-like growth factor-1 receptor: a preclinical study by Heidenberg, Daniel J., Haney, Nora M., Rezk, Bashir M., Talwar, Sudha, Okpechi, Samuel C., Srivastav, Sudesh K., Honda, Matthew, Song, Bryant, Swan, Kevin, Awadallah, Salah, Anaissie, James, Peak, Taylor, DeLay, Kenneth J., Kadowitz, Phillip J., Sikka, Suresh C., Abdel Mageed, Asim B., Hellstrom, Wayne J. G.

“…To determine if the insulin-like growth factor-1 (IGF-1) pathway is involved in the improvement in erectile function recovery in rats after nerve crush injury…”
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Evaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case‐control study by Onor, IfeanyiChukwu O., Duchane, Rose M., Payne, Casey J., Lambert, Hannah Naquin, Mitchner, DeMaurian M., Beyl, Robbie A., Nguyen, Anh T., Bilbe, Sarah E., White, Andrea Arriaga, Johnson, Mariah W., Faciane, Amber I., Kouagou, Emmanuel, Hymel, Stephanie A., Wates, Bria M., Sanders, Asia D., Vo, Phillip C. B., Bates, Jordan D., Spooner, Raven J., Gillard, Christopher J., Okogbaa, John I., Sarpong, Daniel F., Hadgu, Rim M., Okpechi, Samuel C., Onor, Gabriel I., Okoronkwo, Michael C., Naljayan, Mihran V., Guillory, Shane G., Sanne, Shane E.

“…The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive…”
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Evaluation of serum magnesium differences in hypertensive crises and control patients: A randomly matched case‐control study by Onor, IfeanyiChukwu O., Johnston, Emily K., Little, Nicole G., Hill, Lashira M., Lawal, Oluwabunmi E., Payne, Casey J., Coleman, Mallory R., Huynh, Carolkim H., Bilbe, Sarah E., Ayyad, Ahlam A., Jones, Kabrea J., Kinnard, Jasmine D., Dastoori, Rosanna, Rolland, Devinn K., Miller, Amanda S., Beyl, Robbie A., Gillard, Christopher J., Okogbaa, John I., Sarpong, Daniel F., Hadgu, Rim M., Borghol, Amne, Okpechi, Samuel C., Naljayan, Mihran V., Sanne, Shane E., Guillory, Shane G.

“…Although the role of magnesium in blood pressure has been well studied among hypertensive patients, no study has explored the role of magnesium in hypertensive…”
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Correction: ApoE deficiency promotes colon inflammation and enhances the inflammatory potential of oxidized-LDL and TNF-α in primary colon epithelial cells by El-Bahrawy, Ali H, Tarhuni, Abdelmetalab, Kim, Hogyoung, Subramaniam, Venkat, Benslimane, Ilyes, Elmageed, Zakaria Y Abd, Okpechi, Samuel C, Ghonim, Mohamed A, Hemeida, Ramadan A M, Abo-Yousef, Amira M, El-Sherbiny, Gamal A, Abdel-Raheem, Ihab T, Kim, Jong, Naura, Amarjit S, Boulares, A Hamid

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Bilateral vascular repair in a patient with multiple upper extremity injury presenting at a teaching hospital-Case report and literature review by Okpechi, Samuel, Abubakar, Amina

“…Penetrating trauma to the upper extremity will usually result in vascular injuries, which mostly also involves nerves and tendons. Morbidity related to upper…”
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MP45-16 PIOGLITAZONE MEDIATES IMPROVEMENT OF ERECTILE FUNCTION AFTER CAVERNOUS NERVE CRUSH INJURY VIA INSULIN GROWTH FACTOR TYPE 1 by Heidenberg, Daniel, Haney, Nora M, Rezk, Bashir M, Talwar, Sudah, Okpechi, Samuel C, Honda, Matthew, Song, Bryant, Swan, Kevin, Awadallah, Salah, DeLay, Kenneth J, Sikka, Suresh C, Abdel-Mageed, Asim B, Kadowitz, Philip J, Hellstrom, Wayne JG

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